Evolution, Behavior Principles, And Developmental Systems: A Review Of Gottlieb’s Synthesizing Nature-nurture: Prenatal Roots Of Instinctive Behavior.

Gottlieb's developmental psychobiology book provides a base for reexamining the place of the experimental analysis of behavior in the life sciences. His experimental program demonstrating the critical function of the environment in the development of a species‐typical behavior helped force an acceptance of probabilistic epigenesis, the acknowledgment that the developmental genome‐environment system is fully interactional. (Indeed, nature vs. nurture is deader than a doornail.) The repercussions for evolutionary biology and the roles and categorizations of genes, behavior, and environment in behavior‐environment relations are explored in light of current knowledge, including specific implications for the experimental analysis of behavior.     

The self-composing brain: towards a glial-neuronal brain theory

A brain model is proposed which describes its structural organization and the related functions as compartments organized in time and space. On a molecular level the negative feedback loops of clock-controlled genes are interpreted as compartments. This spatio-temporal operational principle may also work on the cellular level as glial-neuronal interactions, wherein glia have a spatio-temporal boundary setting function. The synchronization of the multi-compartmental operations of the brain is compared to the harmonization in a symphony and appears as an integrated behavior of the whole organism, defined as modes of behavior. For explanation of the principle of harmonization, an example from Schubert's Symphony No. 8 has been chosen. While harmonization refers to the synchronization of diverse systems, it seems appropriate to select the brain of a composer and the structure of musical composition as a paradigm towards a glial-neuronal brain theory. Finally, some limitations of experimental brain research are discussed and robotics are proposed as a promising alternative.     

Exploring the Association Between Anxiety and Conduct Problems in a Large Sample of Twins Aged 2–4

Anxiety and conduct problems covary, yet studies have not explored the genetic and environmental origins of this association. We analyzed parent-reported anxiety and conduct problems in 6,783 pairs of twins at 2-, 3-, and 4-years of age. As anxiety and conduct problems were fairly stable across the three ages (average 1-year correlation was .53), ratings from all three were combined. The aggregate anxiety and conduct ratings correlated .33 for boys and .30 for girls. Bivariate genetic analyses indicated fairly low genetic correlations (.31 for boys, .16 for girls), and high shared environmental correlations (1.0 for boys and 0.99 for girls) between anxiety and conduct problems. Most of the phenotypic correlation was accounted for by shared environmental mediation (65% for boys and 94% for girls), indicating that many of the same family environmental factors are responsible for the development of both anxiety and conduct problems.     

The Role of Cognitive Style in the Link Between Genes and Political Ideology

There is growing interest in how genes affect political beliefs. To better understand the role of genes in politics, we examine the relationship between cognitive style (the need for cognition, the need for cognitive closure) and various measures of political attitudes (issue‐based ideology, identity‐based ideology, social ideology, economic ideology, authoritarianism, and egalitarianism). We show, for the first time, that the need for cognition and the need for cognitive closure are heritable and are linked to political ideology primarily, perhaps solely, because of shared genetic influences; these links are stronger for social than economic ideology. Although prior research demonstrated that Openness to Experience shares genetic variance with political ideology, we find that these measures of cognitive style account for distinct genetic variance in political ideology. Moreover, the genetic Openness‐ideology link is fully accounted for by the need for cognition. This combination of findings provides a clearer understanding of the role of genes in political beliefs and suggests new directions for research on Big Five personality traits and ideology.     

Genes and Citizens: Can Moral Philosophy Learn from Evolutionary Biology?

The claim that moral philosophers have something to learn from recent neo-Darwinian theory cannot be sustained – at least, not in the case of the three theses characteristic of the latter on which I concentrate. The first thesis, reductionism, is open to some serious, and familiar, objections. Neo-Darwinism can escape those objections only by weakening its position to a point at which it can no longer be described as distinctively reductionist. The second, atavism, mistakenly attempts to generalise from the apparent persistence of` ‘vestigial’ behaviour patterns. Third, neo-Darwinists are frequently guilty of a number of confusions over the relation between fact and value. In conclusion, I point out that neo-Darwinism derives a certain ideological dynamic from the misleading supposition that patterns of explanation which succeed in one area necessarily apply in others. This revised version was published online in August 2006 with corrections to the Cover Date.     

Genetic Information,Rights, and Autonomy

Rights, autonomy, privacy, and confidentialityare concepts commonly used in discussionsconcerning genetic information. When theseconcepts are thought of as denoting absolutenorms and values which cannot be overriden byother considerations, conflicts among themnaturally occur.In this paper, these and related notions areexamined in terms of the duties and obligationsmedical professionals and their clients canhave regarding genetic knowledge. It issuggested that while the prevailing idea ofautonomy is unhelpful in the analysis of theseduties, and the ensuing rights, an alternativereading of personal self-determination canprovide a firmer basis for ethical guidelinesand policies in this field.     

Effects of early exposure to mating on adult sexual behavior in male mice varying in their genetic disposition for aggressive behavior

This study examined whether the sexual behavior of adult male mice is influenced by exposure in early postnatal life to brief episodes of mating. Another focus of interest was the interplay between a genetic disposition for aggressive behavior and the early exposure experiences. The subjects used in the study were male mice of the fiftysixth generation of selection for high (Turku aggressive, TA) and low (Turku non-aggressive, TNA) levels of aggressiveness. Moderately aggressive males of the parental strain (normal, N) were also used. Subjects of each strain were exposed from 21 to 32 days of age to mating mice behind a wire mesh screen. Control subjects were placed in a comparable enclosure, but were exposed to nothing. The results showed that male mice exposed to mating early in life showed a higher rate of activities in the sexuality tests, including aggressive responses. A genetic potential for aggressive behavior was related to a higher degree of sexual activity, and the early exposures optimized the hereditary attributes. The relation between sexual and aggressive behavior is discussed. © 1994 Wiley-Liss, Inc.     

Odysseans of the Twenty-First Century

In his book Radical Evolution: The Promise and Peril of Enhancing Our Minds, Our Bodies—and What It Means to Be Human (2005), author-journalist Joel Garreau identifies four technologies whose synergistic activity may transform humankind into a state transcending present human nature: genetic, robotic, information, and nano (GRIN) technologies. If the GRIN technologies follow Moore's Law, as information technology has done for the past four decades, Homo sapiens and human society may be unimaginably different before the middle of this century. But among scientists, futurists, and other pundits there is no agreement on the nature and ramifications of this transformation. Based on dozens of interviews, Garreau sees three possible scenarios for our species. The Heaven Scenario foresees enhanced bodies and minds in a disease-free world, perhaps even immortality; the Hell Scenario warns of losing our identity as a biological entity and perhaps the demise of liberal democracy; the Prevail Scenario predicts that we will muddle through the GRIN technology revolution basically intact, as we have prevailed during past technological upheavals. In this review, these scenarios are examined in the context of Kuhn's “normal” versus “extraordinary” science and in the context of current understanding about gene function.     

有关西方心理学中生物学化思潮的质疑与思考

从基因的角度认识人的社会行为,以遗传决定论的观点看待心理和行为的产生和发展,这种生物还原论的观点近年来在西方心理学中有着很大的市场。社会生物学、进化心理学和对行为遗传学研究成果的错误理解和解释是这一思潮的主要代表。实际上,基因的作用是有限的,它并不能决定个体的行为选择。个体发展是基因和环境共同作用的产物,心理与行为是受文化制约的,文化决定了个体心理的发展过程。     

基因与人性:影响人性的若干基因

人类行为既受到遗传因素的影响,同时也受到环境(文化)因素的影响。近年来逐渐引起众多学科领域关注的行为遗传学研究从行为的基因关联出发,系统研究了行为的遗传因素及其基因基础,取得了令人瞩目的成绩。该文系统总结了八种人类重要行为的基因基础及其与环境因素的关系,并从基因与人性的关系角度进行了讨论。