Understanding memory impairment with memory models and hierarchical Bayesian analysis

The study of human episodic memory is a topic that interests cognitive and mathematical psychologists as well as clinicians interested in the diagnosis and assessment of Alzheimer’s disease and related disorders (ADRD). In this paper, we use simple cognitive models for the recognition and recall tasks typically applied in clinical assessments of ADRD to study memory performance in ADRD patients. Our models make use of hierarchical Bayesian methods as a way to model individual differences in patient performance and to facilitate the modeling of performance changes that occur during multiple recall tasks. We show how the models are able to account for different aspects of patient performance, and also discuss some of the predictive capabilities of the model. We conclude with a discussion on the scope to improve on our results by discussing the link between memory theory in psychology and clinical practice.     

The psychological neuroscience of depression: implications for understanding effects of deep brain stimulation

In this article it is suggested that current psychological theories of depression presuppose that this condition will develop as a result of a vicious circle involving negatively biased communication between systems of emotional stress-/alarm-signaling, executive functions and mood regulation. These systems may from a neuroanatomical point of view be located in the limbic system, the orbitofrontal and lateral prefrontal cortex and the hypothalamus-pituitary-adrenal (HPA-) axis respectively. The theoretical and practical implications of this model for the understanding of pharmacological treatments of depression are briefly discussed and this theory is related to the catecholamine hypothesis of depression. The model is furthermore discussed in relation to deep brain stimulation (DBS) of treatment resistant major depression. Similarities and differences between this perspective and the one advocated by the "homeostatic theory" of depression are discussed. It is concluded that a topographical psychological theory may offer a useful heuristic in thinking about depression and that it offers several testable predictions about treatments of the disorder.     

Lasting effects of alcohol: Subliminal alcohol cues,impairment expectancies,and math performance

Many people believe that drinking alcohol reduces cognitive performance, and prior research has shown such expectancy‐related impairment even when people merely thought that the (non‐alcoholic) drink they consumed contained alcohol. This study tested whether subliminal priming with alcohol‐related cues would similarly result in expectancy‐consistent cognitive performance decrements. Additionally, the moderating role of alcohol use was examined. After assessing participants' baseline math performance, participants were primed with alcohol‐related or neutral words and then completed a post‐treatment math task. Whereas impairment expectancies had no influence on math performance in control participants, expectancies predicted math performance for participants primed with alcohol‐related words. As hypothesized, expectancy‐consistent impairment in performance was only observed among high alcohol users. The current findings suggest that, in the presence of alcohol‐related cues in the environment, some people may perform less on cognitive tasks even in the absence of actual or assumed alcohol consumption and without being aware of it. Copyright © 2011 John Wiley & Sons, Ltd.     

Sex differences in latent cognitive abilities ages 5 to 17: Evidence from the Differential Ability Scales—Second Edition

Sex differences in the latent general and broad cognitive abilities underlying the Differential Ability Scales, Second Edition were investigated for children and youth ages 5 through 17. Multi-group mean and covariance structural equation modeling was used to investigate sex differences in latent cognitive abilities as well as changes in these differences across age. Most broad abilities showed mean differences across the sexes, and all such differences varied across ages. Girls showed an advantage on the processing speed (Gs) first-order residual factor. Girls also showed advantages at some ages on free-recall memory, a narrow ability of long term retrieval (Glr). Boys showed a developmentally-related advantage on a visual-spatial ability (Gv) first-order residual factor, depending on age. Younger girls showed an advantage on short-term memory (Gsm). No statistically significant sex differences were shown on the latent comprehension-knowledge (Gc) factor, or on a second-order, latent g factor. Boys showed larger variances for several broad abilities, some substantial, but those differences were not statistically significant.     

Differentiating intolerance of uncertainty from three related but distinct constructs

Individual differences in uncertainty have been associated with heightened anxiety, stress and approach-oriented coping. Intolerance of uncertainty (IU) is a trait characteristic that arises from negative beliefs about uncertainty and its consequences. Researchers have established the central role of IU in the development of problematic worry and maladaptive coping, highlighting the importance of this construct to anxiety disorders. However, there is a need to improve our understanding of the phenomenology of IU. The goal of this paper was to present hypotheses regarding the similarities and differences between IU and three related constructs – intolerance of ambiguity, uncertainty orientation, and need for cognitive closure – and to call for future empirical studies to substantiate these hypotheses. To assist with achieving this goal, we conducted a systematic review of the literature, which also served to identify current gaps in knowledge. This paper differentiates these constructs by outlining each definition and general approaches to assessment, reviewing the existing empirical relations, and proposing theoretical similarities and distinctions. Findings may assist researchers in selecting the appropriate construct to address their research questions. Future research directions for the application of these constructs, particularly within the field of clinical and health psychology, are discussed.     

Negative cognitive style and looming cognitive style synergistically predict stress generation

There is a growing body of evidence that suggests that cognitive vulnerabilities to depression or anxiety may lead individuals to generate negative interpersonal life events. However, there has been no study to date that examines the effects of co-occurring vulnerabilities to depression and anxiety. In a sample of 304 participants, we examined the potential interaction of co-occurring negative cognitive style, a vulnerability to depression and looming cognitive style, vulnerability to anxiety. Results indicate that co-occurring cognitive vulnerabilities synergistically predict higher levels of negative interpersonal life events six weeks later, even when controlling for initial levels of stressful life events and symptoms of depression and anxiety. Thus, co-occurring vulnerabilities may have stronger stress generating effects than would be expected from the additive effects of each vulnerability considered separately. This finding highlights the importance of examining cognitive vulnerabilities as interactive effects rather than as individual vulnerabilities.     

Vulnerability-specific stress generation: an examination of depressogenic cognitive vulnerability across multiple domains

Background and Objectives: Although there is supporting evidence for the stress generation hypothesis (i.e., the tendency for depression-prone individuals to experience more negative dependent events influenced by their behaviors and characteristics), additional research is required to advance current understanding of the specific types of dependent events relevant to this effect. The present study elaborated on the stress generation hypothesis, in which the content of negative dependent events experienced by individuals is contingent upon, and matches, the nature of their particular vulnerabilities. This extension was tested within the context of Cole's competency-based model of depression. Design: Participants (n = 185) were assessed at two time-points separated by a four-month interval. Methods: Self-perceived competence in academic, social, and appearance domains at the initial time-point were examined in relation to negative life events prospectively occurring over the four-month follow-up period, assessed using the “contextual threat” method. Results: Partial support was obtained for vulnerability-specific stress generation. Stress-generation specificity was found for self-perceived competence in appearance and academic domains, but not for self-perceived social competence. Conclusions: The current findings are consistent with the possibility of a more complex relation between self-perceived social competence and domain-congruent stress generation. Individuals may be more likely to experience negative dependent events in domains matching their specific vulnerabilities.     

Response to Algarabel et al., 2012 “Recognition memory deficits in mild cognitive impairment”. Reconsidering claims of familiarity disruptions in mild cognitive impairment

There is some debate over the relative impairment of recollection and familiarity in mild cognitive impairment (MCI). A recent publication by Algarabel et al. (2012, Recognition memory deficits in mild cognitive impairment, Aging, Neuropsychology, and Cognition, 19, 608–619) claims to undermine previous studies reporting preserved familiarity in patients with MCI. Here, we respond to their main criticisms, concluding that they are not sufficiently supported by the data presented. The role of recollection and familiarity in MCI remains unresolved and further work will be required to disentangle the mixed literature.     

A model for integrating spiritual education into secular curricula

The purpose of this article is to illustrate how the model proposed initially by De Souza and developed by Buchanan and Hyde for religious education can be applied to secular education. Using the context of an action research project in Mainland China to introduce education in human values to government primary schools, examples are drawn from mathematics topics to show how teachers have been able to integrate cognitive, affective and values messages into their existing subject curricula. Children’s and teachers’ comments suggest that both are aware of the inner transformations that occur over time, and illustrate that it is possible to bring about such transformation in a way that is compatible with the ideology of the system.