应当重视肿瘤微环境中外因的研究

长期以来,肿瘤学的几乎所有研究一直在关注肿瘤细胞本身,从哲学角度看这无疑是正确的。肿瘤细胞是肿瘤事件发生发展的内因。近年研究表明,肿瘤的外因,即肿瘤微环境中的非肿瘤细胞及其产物,对肿瘤的发生发展起着十分重要的作用。肿瘤微环境的外因,通过作用于内因选择了更具抵抗性的肿瘤细胞,促进了肿瘤的进展与转移。因此,重视肿瘤微环境的外因研究,对肿瘤治疗学将会开辟以外因为靶点干预的新思路。     

非小细胞肺癌 EG FR 基因突变检测与临床意义

采用荧光PCR法对199例晚期非小细胞肺癌（NSCLC ）组织进行表皮生长因子受体（EGFR ）基因突变检测,分析EGFR基因突变的分布特征及其与临床病理特征的相关性。结果显示56例（28．1％）存在EGFR基因突变,其中27例（13．6％）为外显子19突变,25例（12．6％）为外显子21突变,2例为外显子18突变,1例外显子20突变,1例外显子18和20的共突变。另外,除广东及安徽省铜陵市外,辽宁地区NSCLC患者EGFR基因突变率及主要突变类型与其他地区相符,常见于外显子19、21突变,其中腺癌、不吸烟患者突变率更高,更适宜EGFR-TKI靶向治疗。     

高效率学习的心理机制研究

本课题通过一系列研究,发现要实现高效率学习,应在知识呈现符合学生认识规律的情况下,具备以下五个主要心理要素:选择性注意是实现高效率学习的前提,元认知是高效率学习的监控系统,非智力因素是高效率学习的动力源泉,学习策略是实现高效率学习的保障,内隐认知,特别是内隐学习是高效率学习的特殊形式。     

大学生学习适应量表的编制

对当代大学生学习适应问题进行了深入分析,在有关研究的基础上,探讨了当代大学生学习适应的主要因素,并编制一套适合当代大学生学习适应的测验。对四类院校918名大学生进行了施测,对调查数据进行了探索性因素分析和验证性因素分析。探索性因素分析结果表明,大学生学习适应的主要因素包括学习动机、教学模式、学习能力、学习态度、环境因素等5个方面;验证性因素分析结果表明,所提取的5个因素与构想模型拟合较好,测验具有较好的信、效度     

“己之所欲”还是“成人之美”？解释水平视角下个体赠送-接受礼物的偏好不对称性

解释水平理论被广泛应用于消费研究领域。本研究以解释水平理论为理论基础,采用情境问卷调查方法,通过5个实验探讨个体赠送与接受礼物时是否存在性别和角色偏好的不对称性。结果发现,一般情境下,受性别因素影响,男生偏好赠送和接受工具性礼物,女生偏好赠送和接受表达性礼物。但随着心理距离（社会距离和空间距离）的拉近,个体的解释水平降低,更关心他人的喜好和需求,赠送者会更基于接收者的偏好进行礼物选择。     

A note on residual M-distances for identifying aberrant response patterns

Although a statistical model might fit well to a large proportion of the individuals of a random sample, some individuals might give ‘unusual’ responses that are not well explained by the hypothesized model. If individual responses are given as continuous response vectors, M-distances can be used to produce real valued indicators of how well an individual's response vector corresponds to a covariance structure implied by a psychometric model. In this note, we focus on the so-called one-factor model. Two M-distances, d_si and d_ri, which are sensitive to different aspects of the assumed factor model, have been proposed. While one of the M-distances, d_ri, has been derived based on Bartlett factor scores, in this note we show that the second M-distance, d_si, can be derived in an analogous fashion based on Thomson factor scores.     

Consequences of Ignoring Guessing Effects on Measurement Invariance Analysis

Pseudo-guessing parameters are present in item response theory applications for many educational assessments. When sample size is not sufficiently large, the guessing parameters may be ignored from the analysis. This study examines the impact of ignoring pseudo-guessing parameters on measurement invariance analysis, specifically, on item difficulty, item discrimination, and mean and variance of ability distribution. Results show that when non-zero guessing parameters are ignored from the measurement invariance analysis, item discrimination estimates tend to decrease particularly for more difficult items, and item difficulty estimates decrease unless the items are highly discriminating and difficult. As the guessing parameter increases, the size of the decrease in item discrimination and difficulty tends to increase, and the estimated mean and variance of ability distribution tend to be inaccurate. When two groups have heterogeneous ability distributions, ignoring the guessing parameter affects the reference group and the focal group differently. Implications of result findings are discussed.