Renewal of fear and avoidance in humans to escalating threat: Implications for translational research on anxiety disorders

Exposure-based treatment for threat avoidance in anxiety disorders often results in fear renewal. However, little is known about renewal of avoidance. This multimodal laboratory-based treatment study used an ABA renewal design and an approach–avoidance (AP–AV) task to examine renewal of fear/threat and avoidance in twenty adults. In Context A, 9 visual cues paired with increases in probabilistic money loss (escalating threats) produced increases in ratings of feeling threatened and loss expectancies and skin-conductance responses (SCR). During the AP–AV task, a monetary reinforcer was available concurrently with threats. Approach produced the reinforcer or probabilistic loss, while avoidance prevented loss and forfeited reinforcement. Escalating threat produced increasing avoidance and ratings. In Context B with Pavlovian extinction, threats signaled no money loss and SCR declined. During the AP–AV task, avoidance and ratings also declined. In a return to Context A with Pavlovian threat extinction in effect during the AP–AV task, renewal was observed. Escalating threat was associated with increasing ratings and avoidance in most participants. SCR did not show renewal. These are the first translational findings to highlight renewal of avoidance in humans. Further research should identify individual difference variables and altered neural mechanisms that may confer increased risk of avoidance renewal.     

Core Job Characteristic and Uncertainty Avoidance: Into the Black Box of Transformational Leadership Effect on Creativity

Drawing upon the job characteristic model and the “management of meaning” perspective, this study examines the process and conditions through which transformational leadership fosters employee creativity. Our results reveal that the effect of transformational leadership on creativity is mediated by employees’ perceptions of core job characteristics (variety, identity, significance, autonomy, feedback). This mediation effect is further moderated by employees’ uncertainty avoidance orientation. Specifically, transformational leaders foster creativity through followers’ perceptions of core job characteristics only among employees low on uncertainty avoidance. The association between enhanced job characteristics and creativity is more positive for employees with low uncertainty avoidance orientation than those with high uncertainty avoidance orientation. Implications and future research directions are discussed.     

The role of individual differences in emotion regulation efficacy

Emotion regulation (ER) helps to maintain mental health and achieve optimal functioning. Whether people benefit from various ER strategies may depend on individual difference variables. A sample of undergraduates (N = 378, M_age = 18.6) underwent a negative emotion induction and then were assigned to learn about and perform an ER strategy (cognitive reappraisal, acceptance, or distraction). We tested whether individual differences (cognitive restructuring skills, need for cognition, mindfulness, and experiential avoidance) moderated the efficacy of ER (i.e., decreased negative emotion from before to after applying the strategy). Experientially avoidant individuals had less efficacy in applying the acceptance strategy, compared to the cognitive reappraisal and distraction strategies. Motivation and perceived ability to use each strategy were examined as mediators.     

Solving the puzzle of deliberate self-harm: the experiential avoidance model

Despite increasing attention to the phenomenon of deliberate self-harm (DSH), the literature currently lacks a unifying, evidence-based, theoretical framework within which to understand the factors that control this behavior. The purpose of the present paper is to outline such a framework-the Experiential Avoidance Model (EAM) of DSH. The EAM poses that DSH is primarily maintained by negative reinforcement in the form of escape from, or avoidance of, unwanted emotional experiences. Literature on factors that may lead to experiential avoidance is reviewed, along with the mounting empirical evidence that DSH functions to help the individual escape from unwanted emotional experiences. The EAM integrates a variety of research on emotions, experiential avoidance, and DSH within a clinically useful framework that sparks novel research directions.     

Approach/avoidance motivation, message framing, and health behavior: understanding the congruency effect

Health messages framed to be congruent with individuals’ approach/avoidance motivations have been found to be more effective in promoting health behaviors than health messages incongruent with approach/avoidance motivations. This study examines the processes underlying this congruency effect. Participants (undergraduate students, N=67) completed a measure of approach/avoidance orientation (the BIS/BAS scales) and read either a gain- or loss-framed message promoting dental flossing. Results demonstrated a congruency effect: Participants who read a congruently framed message had greater flossing efficacy, intended to floss more, and used more dental flosses than did the participants who read an incongruent message. Moreover, intention to perform the behavior predicted the congruency effect and self-efficacy mediated participants’ intentions to perform the health behavior. Discussion centers on the role of personality factors and situational factors in models of behavior change.

A few minor suggestions.

We agree with almost all of the analysis in this excellent presentation of the molecular view of avoidance behavior. A few suggestions are made as follows: Referring to response-generated stimuli as 'readily observable" seems not quite right for the kinesthetic components of such stimuli, although their scientific legitimacy is not questioned. Interpreting response-generated stimuli as a form of positive reinforcement is contested, and an alternative interpretation is offered. A possibly simpler interpretation of the Sidman (1962) two-lever experiment is suggested. We question Dinsmoor's (2001) explanation for warning stimuli not being avoided, except for the reference to the weakness of third-order conditioning effects. A final question is raised regarding the nature of the variables that are responsible for the momentary evocation of the avoidance response.     

Safe periods both explain and need explaining.

Dinsmoor's (2001) stress on the response‐produced safe period as a reinforcer for avoidance behavior is a positive contribution, even though several questions about such safe periods remain to be answered.     

Beyond the molar-molecular distinction: we need multiscaled analyses.

Dinsmoor's (2001) adherence to molecular analyses may require him to assert that molar and molecular principles are mutually exclusive, but to instead analyze the phenomena of avoidance as inherently multiscaled is to follow a well-established practice in the natural sciences. Besides the issue of scale, two-factor theory, which Dinsmoor advocates, has little to say about some important and longstanding results in experiments that qualify as avoidance.     

Lesions in the Central Nucleus of the Amygdala: Discriminative Avoidance Learning, Discriminative Approach Learning, and Cingulothalamic Training-Induced Neuronal Activity

The amygdala is critically involved in discriminative avoidance learning. Large lesions of the amygdala block discriminative avoidance learning and abolish cingulothalamic training-induced neuronal activity. These results indicated that amygdalar processing is critical for cingulothalamic plasticity. The larger lesions did not allow differentiation of the specific functioning of various amygdalar nuclei. Anatomical analysis showed that damage in the central (CE) nucleus of the amygdala was correlated with the severity of the behavioral deficit. The present study was carried out to determine whether smaller lesions, centered in the CE nucleus, would impair discriminative avoidance learning and block cingulothalamic plasticity. In addition, the possible role of the CE nucleus in appetitively motivated discriminative approach learning was examined for the first time. New Zealand White rabbits with CE nuclear lesions were first trained in the discriminative approach task. After attaining asymptotic performance, discriminative avoidance training sessions were alternated with continuing approach training sessions, one session each day. The rabbits with lesions were severely impaired in avoidance learning but showed no impairment of approach learning. Surprisingly, the attenuating effects of the lesions on cingulothalamic training-induced neuronal activity were more prevalent during approach learning than during avoidance learning. These results indicated that avoidance learning can be impaired by lesions centered in the CE nucleus that leave cingulothalamic plasticity largely intact and that the CE nucleus is involved in extra-cingulothalamic learning processes.     

Color and Psychological Functioning

ABSTRACT— Color is a ubiquitous perceptual experience, yet little scientific information about the influence of color on affect, cognition, and behavior is available. Accordingly, we have developed a general model of color and psychological functioning, which we present in this article. We also describe a hypothesis derived from this model regarding the influence of red in achievement contexts. In addition, we report a series of experiments demonstrating that a brief glimpse of red evokes avoidance motivation and undermines intellectual performance, and that it has these effects without conscious awareness or intention. We close with thoughts on the need for rigorous scientific work on color psychology.