自由基与重度颅脑外伤并发SIRS的原因及治疗研究探讨

就重型颅脑外伤由于过氧化反应后自由基产生的原因、自由基对神经细胞的继发损伤、自由基在重型颅脑外伤状态下诱发或并发全身炎性反应综合征以及两种因素所引起的神经细胞凋亡进行综述。同时就目前学者们在手术抢救、监测血液粘度、持续腰大池置管脑脊液外引流术、亚低温治疗、药物治疗、高压氧与活性氧液治疗、恒定磁场治疗等方面治疗自由基和全身炎性反应综合征对神经细胞的继发损伤进行了讨论。重型颅脑外伤后应重视自由基和全身炎性反应综合征的治疗。     

A method for describing preschoolers' activity preferences

We designed a series of analyses to develop a measurement system capable of simultaneously recording the free-play patterns of 20 children in a preschool classroom. Study 1 determined the intermittency with which the location and engagement of each child could be momentarily observed before the accuracy of the measurement was compromised. Results showed that intervals up to 120 s introduced less than 10% measurement error. Study 2 determined the extent of agreement between two observers who simultaneously collected data for 20 children using 30-, 60-, 90-, and 120-s momentary time sampling (MTS) intervals. The three larger intervals resulted in high levels of interobserver agreement (above 90%), whereas the 30-s interval resulted in unacceptably low levels of agreement (less than 80%). By allowing observers to select from among the different MTS intervals via a datasheet array and then collect data with the chosen system, Study 3 determined observers' preferences for the remaining MTS intervals. Both data collectors preferred the 90-s MTS procedure. The sensitivity of the 90-s MTS procedure, which was shown to be accurate, reliable, and preferred, was then demonstrated by its use to describe activity preferences of a classroom of children in Study 4. This system identified high- and low-preference activities for individual children and revealed interesting patterns of response allocation by the group.     

Stochastic matching and the voluntary nature of choice

Attempts to characterize voluntary behavior have been ongoing for thousands of years. We provide experimental evidence that judgments of volition are based upon distributions of responses in relation to obtained rewards. Participants watched as responses, said to be made by "actors," appeared on a computer screen. The participant's task was to estimate how well each actor represented the voluntary choices emitted by a real person. In actuality, all actors' responses were generated by algorithms based on Baum's (1979) generalized matching function. We systematically varied the exponent values (sensitivity parameter) of these algorithms: some actors matched response proportions to received reinforcer proportions, others overmatched (predominantly chose the highest-valued alternative), and yet others undermatched (chose relatively equally among the alternatives). In each of five experiments, we found that the matchingactor's responses were judged most closely to approximate voluntary choice. We found also that judgments of high volition depended upon stochastic (or probabilistic) generation. Thus, stochastic responses that match reinforcer proportions best represent voluntary human choice.     

法兰克福型例和兼容论

本文首先对当代的自由意志问题进行简要概述,其次阐述法兰克福型例的论证和目的,及其他学者对该型例的批判,并提出自己的一些观点,最后通过对法兰克福型例的改进,进一步的探讨自由意志问题,维护传统的自由意志的观念,并进一步维护自由意志和决定论相兼容的立场。     

PHILOSOPHY IN FRAGMENTS: CULTIVATING PHILOSOPHIC THINKING WITH THE PRESOCRATICS

Abstract: This article presents a strategy for introducing Presocratic thought to students in a manner that is both engaging and relevant. The first section addresses students' reactions to the claim that the Presocratics were the first philosophers. The second section considers how the fragmentary state of Presocratic thought does not hinder its comprehension. The third section proposes a classroom exercise for testing the scientific merits of each of the Presocratic theories. The final section proposes the use of a mock trial as a means of applying the materialist approach introduced by the Presocratics to contemporary debates about free will and determinism.     

非稳态噪声对动物行为及心脏自由基损伤的影响

本研究用采集的多用木工机床和冲击电钻发出的噪声对 5天、1 0天和 2 0天三个噪声干扰组的动物进行干扰 ,以研究非稳态噪声对动物行为及心脏组织自由基损伤的影响。结果发现 ,非稳态噪声可引起动物旷场反应中走格数减少 ,站立及洗脸次数增加 ,并可诱发心脏组织的自由基反应 ,导致心脏组织的损害。因此得出结论 :①非稳态噪声可以对动物行为产生影响 ,并随着噪声暴露时间的延长而增强 ;②非稳态噪声可以造成心脏组织的自由基损伤。这一现象提示自由基损伤是介导噪声对心脏功能影响的重要因素之一。     

晚期汉-英二语者英语被动句句法加工的ERP研究*

选取二语中等熟练者和高熟练者两类中国大学生被试,共40人(27女,13男),年龄为20~29岁,平均年龄23.88岁。采用ERP技术,以直译型英语被动句和意译型英语被动句作为实验材料,通过比较无违例、―句法违例句1‖(动词过去分词形式错误)、―句法违例句2‖(动词过去分词错误用为动词原形而造成的句法违例)以及―句法违例句3‖(动词过去分词误用为动词现在分词形式)条件下的行为数据和ERP多维数据变化的基础上,探讨了二语熟练度和语言间句法结构相似性对汉-英双语者英语被动句句法加工过程的影响。结果表明：高熟练者的反应时和正确率整体上优于中等熟练者;难易度不同的句法错误信息会直接影响被动句的加工,对明显有错误的句法信息的反应速度最快,―正确的局部句法信息‖反应时最长。对明显有错误的句法信息的正确反应率最高,最根本的句法结构的错误信息最低。最根本的句法结构的错误信息引发的P600最大,无违例条件引发的P600最小;高熟练者对最根本的句法结构的错误信息引发最大的P600效应,中等熟练者的P600效应未受不同句法错误信息的影响。行为指标支持句法加工相似性效应——直译句反应快、正确率高;意译句反应慢、正确率低。并且此效应在中等熟练者身上表现更加明显。但是脑神经活动模式未表现出句法结构相似性效应,说明二语熟练度在英语被动句加工中具有更为显著的作用。     

Interviewing intoxicated witnesses: Memory performance in theory and practice

Memory encoding and recall involving complex, effortful cognitive processes are impaired by alcohol primarily due to impairment of a select few, but crucial, cortical areas. This review shows how alcohol affects some, but not all, aspects of eyewitnesses' oral free recall performance. The principal results, so far, are that: a) free recall reports by intoxicated witnesses (at the investigated BAC‐levels) may contain less, but as accurate, information as reports by sober witnesses; b) immediate reports given by intoxicated witnesses may yield more information compared to reports by sober witnesses given after a one week delay; c) an immediate interview may enhance both intoxicated and sober witnesses' ability to report information in a later interview; and d) reminiscence seems to occur over repeated interviews and the new information seems to be as accurate as the previously reported information. Based on this, recommendations are given for future research to enhance understanding of the multifaceted impact of alcohol on witnesses' oral free recall of violent crimes.     

EGO-LESS AGENCY: DHARMA-RESPONSIVENESS WITHOUT KANTIAN AUTONOMY

My critical focus in this article is on Rick Repetti's compatibilist conception of free will, and his apparent commitment to a Kantian conception of autonomy, which I argue is in direct conflict with the Buddhist doctrine of no-self. As an alternative, I defend a conception of ego-less agency that I believe better coheres with core Buddhist teachings. In the course of the argument, I discuss the competing conceptions of free agency and autonomy defended by Harry Frankfurt, John Martin Fischer, Christine Korsgaard, and David Velleman.