This article discusses age-related changes in brain weight, total number of cortical neurons, cortical dendrites, spine, and synapse density. The conclusion is that the present outlook is less grim than it was 30 years ago. Age-related reduction appears to be specific to brain region and cortical layer rather than a general feature. In addition, we describe a different pattern of changes that occur in Alzheimer's disease patients. This review concludes that the association cortices in particular are affected in aging and Alzheimer's disease and that the primary visual and somatosensory cortices are relatively spared. 相似文献
Using free energy rate density (Φm) I differentiate two evolutionary strategies common to cosmic, biological, and cultural systems: the horizontal when energy increases proportional to mass, with no increase in complexity; and the vertical when it increases disproportionately to the mass and complexity increases. The vertical process is a continuing increase in complexity such that the system becomes vulnerable to collapse when energy sources fail. This is illustrated by a comparison of four Mayan Indian groups in Guatemala. 相似文献
Central to Augustine's understanding of rightly ordered sexuality is his belief that the pleasure of the act should not be separated from its good (procreation). It is useful to observe that he reasons in a similar way about eating: that the pleasure of eating should not be separated from its good (nourishment). Inadequacies in his understanding of the purpose of food and eating may be instructive when we think about inadequacies in his understanding of sex. If there is more to food than he imagines, the same may be true of sex. Correcting for such inadequacies may also help correct for the (inadvertent) way in which his understanding of the purpose of sex may seem to legitimize technologies of assisted reproduction. 相似文献
Objective: Food allergies are a growing health concern, but their implications for daily psychological functioning are unknown. This micro-longitudinal study investigated the daily frequency of food allergy issues and how this related to experiences of stress, mood and physical energy.
Design: One hundred and eight adults with physician-diagnosed food allergies completed an initial Internet survey followed by a 2-week Internet daily diary survey.
Main outcome measures: The initial survey collected socio-demographic and food allergy information. The daily survey collected information about the participants’ experiences of stress, mood, physical energy and food allergy issues during that day.
Results: Commonly experienced allergy issues included negative physical symptoms, higher food prices, anxiety about safety of food, trouble maintaining a healthy diet and anxiety/stress at social occasions. Furthermore, multilevel modelling analyses showed that stress and negative mood were significantly higher on days with more allergy issues. Older adults experienced lower positive mood and physical energy on days with more issues.
Conclusion: This is the first study to incorporate near to real-time tracking to examine the frequency of food allergy issues and the implications for daily psychological functioning. Targeting the issues we identified could reduce stress in patients with food allergies and improve their overall quality of life. 相似文献
A statistical manifold Mμ consists of positive functions f such that defines a probability measure. In order to define an atlas on the manifold, it is viewed as an affine space associated with a subspace of the Orlicz space LΦ. This leads to a functional equation whose solution, after imposing the linearity constrain in line with the vector space assumption, gives rise to a general form of mappings between the affine probability manifold and the vector (Orlicz) space. These results generalize the exponential statistical manifold and clarify some foundational issues in non-parametric information geometry. 相似文献
Two experiments addressed the effects of food satiation and deprivation on oral self-administration of two concurrently available phencyclidine concentrations. In the first experiment, 8 rhesus monkeys self-administered either of two concentrations of phencyclidine ("PCP, angel dust") and water under concurrent fixed-ratio 16 schedules. One concentration was always held constant (0.25 mg/mL) while a series of other phencyclidine concentrations, ranging from 0 (water) to 1.0 mg/mL, was presented in a nonsystematic order. Initially the monkeys were tested while food satiated, and the procedure was then repeated during food deprivation. The monkeys usually selected the higher concentration within the first few minutes of the session, indicating that taste and/or other immediate postingestional effects were important factors. Contrary to a number of previous reports, there were no consistent differences across subjects in the mean number of liquid deliveries or mean drug intake (mg/kg) during food satiation and deprivation. However, for all monkeys the within-session time course of responding during food satiation consistently differed from that during deprivation. A second experiment assessed whether the failure to find consistent differences in drug intake during food satiation and deprivation had been due to the history of concurrent access to different phencyclidine concentrations or to the extended experience with phencyclidine under food-satiation conditions. Six additional monkeys (Group 2) were exposed to the phencyclidine self-administration procedure (during food satiation and deprivation) for the same length of time as the monkeys in Experiment 1 (Group 1), except they received only concurrent access to phencyclidine (0.25 mg/mL) and water. Both groups then received concurrent access to phencyclidine and water during five repeated cycles of food deprivation and satiation. There were also marked individual differences in Group 2: During food satiation, 2 of the monkeys' responding increased, 1 showed no change, and 3 decreased. Examination of a number of historical variables indicated that the greater the percentage of total sessions spent during food satiation with phencyclidine available (before these experiments began), the greater the amounts of phencyclidine consumed during food satiation and the smaller the differences in phencyclidine intake when the two feeding conditions were compared. 相似文献
In Experiment I, the responding of rats lever pressing on a variable-interval schedule for sucrose solution was partially suppressed by a variable duration conditioned stimulus followed by shock. When food deprivation was increased, response rates during and before the conditioned stimulus increased monotonically. Varying the concentration of sucrose across blocks of sessions or from session to session in a semi-random sequence had little effect on response rates either before or during the conditioned stimulus. With a fixed sequence of increasing concentrations across a five-session block, increased concentration produced much more rapid increases in response rates before than during the conditioned stimulus. In Experiment II, rats were presented with the same sequence of increasing concentrations across a five-session block. When tested at 80% body weight, response rates increased rapidly as concentration increased, but at 100%, body-weight rates increased only slightly. The effect of a change in body weight in Experiment II thus mimicked the effect of the conditioned stimulus in the latter part of Experiment I. These findings support the view that the effect of a pre-aversive conditioned stimulus is similar to that of a change in food deprivation, but unlike that of a change in reinforcement magnitude. 相似文献