Information on the difference in cognitive function between laboratory and wild-caught mice is anecdotal and this question has not been systematically studied. Moreover, studying a wild-caught mouse strain per se may add information to the repertoire of mouse strains available. We aimed to study spatial memory in a wild mouse strain (Apodemus sylvaticus, AS) as compared to two individual laboratory mouse strains.Male AS (n = 20), CD1 (n = 19) and C57BL/6J mice (n = 19), 12–14 weeks old, were used in the experiments. The Morris water maze (MWM) was used for determination of spatial memory and time spent in the target quadrant at time points 5 (D5) and 12 days (D12) was evaluated. During the acquisition phase latency to reach the platform and path length to reach the platform was evaluated.Following four training days on day 5 (D5), time spent in the target quadrant was highest in AS > CD1 > C57BL/6J (P < 0.006). On day 12 (D12), time spent in the target quadrant was significantly higher in AS than in both other strains (P < 0.001).All animals learned the task and during the acquisition phase, latency to reach the platform as well as path length decreased significantly in AS.It is concluded that the AS is the most suitable strain for the evaluation of spatial memory in the MWM and is presenting with memory retention superior to laboratory mouse strains CD1 and C57BL/6J. 相似文献
We investigated the effects of grade retention in first grade on the growth of the Woodcock-Johnson broad mathematics and reading scores over three years using linear growth curve modeling on an academically at-risk sample. A large sample (n = 784) of first grade children who were at risk for retention was initially identified based on low literacy scores. Scores representing propensity for retention were constructed based on 72 variables collected in comprehensive baseline testing in first grade. We closely matched 97 pairs of retained and promoted children based on their propensity scores using optimal matching procedures. This procedure adjusted for baseline differences between the retained and promoted children. We found that grade retention decreased the growth rate of mathematical skills but had no significant effect on reading skills. In addition, several potential moderators of the effect of retention on growth of mathematical and reading skills were identified including limited English language proficiency and children's conduct problems. 相似文献
Students retained in grade have dropout rates three to seven times higher than do their promoted peers, yet little is known about the outcomes for the most persistent of the retained students who graduate high school. The purpose of this research was to examine the post-secondary (PSE) enrollment rates of retained but persistent high school graduates. Ten thousand 1992 high school graduates in the National Education Longitudinal Study (NELS) data base composed the sample. A logistic regression controlling for gender, socio-economic status (SES), race–ethnicity, and achievement yielded odds ratios indicating significantly lower odds of PSE enrollment for retained graduates compared to promoted graduates. Later grade retention generally reduced the odds of PSE enrollment. Findings suggest that retaining students may be related to negative educational outcomes not realized for many years. 相似文献
Minimizing participant attrition is vital to the success of longitudinal research. The Developmental Trends Study (DTS), a longitudinal study of the development of disruptive behavior disorders, has achieved a low attrition rate throughout the study. The development of early retention strategies, managing contact and scheduling history through the use of electronic databases, interviewer persistence, and the emergence of new electronic search methods have contributed to the success of our study. A literature review of retention methodology and practical solutions to maintain participant cooperation is described. A case study of the DTS is presented to inform researchers in longitudinal research on new methods used to maintain high retention rates. 相似文献
Two monkeys experienced with delayed matching to sample were given a 30-day baseline training period during which the delay interval was illuminated. Both subjects showed an increase in matching accuracy when shifted to dark delay intervals, and accuracy declined when the illuminated delay interval was reinstituted. These results, as well as earlier reports of facilitation of delayed matching behavior by dark delay intervals, support the view that the absolute level of delay-interval illumination can importantly affect visual retention in monkeys and may be indicative of significant differences in the retention mechanisms employed by monkeys and birds. 相似文献
Students learn large amounts of information, but not all of it is remembered after courses end – meaning that valuable class time is often spent reviewing background material. Crucially, laboratory research suggests different strategies will be effective when reactivating previously learned information (i.e. marginal knowledge), as opposed to learning new information. In two experiments, we evaluated whether these laboratory results translated to the classroom. Topics from prior courses were tested to document which information students could no longer retrieve. Half were assigned to a not-tested control and half to the intervention; for these topics, students answered multiple-choice questions (without feedback) that gave them the chance to recognize the information they had failed to retrieve. Weeks later, students completed a final assessment on all topics. Crucially, multiple-choice testing increased the retrieval of previously forgotten information, providing the first classroom demonstration of the reactivation of marginal knowledge. 相似文献
This study quantifies the prevalence and associated characteristics of subjects in a longitudinal study who are difficult to schedule and thus may become potential study dropouts. Although subject attrition over three years remained extremely low, many families were difficult to schedule for their assessments and this remained rather constant over time. Intercorrelations between the measures of scheduling difficulty were high, indicating good internal validity of the constructs. Stability of these measures from year to year was low, making it difficult to predict which families required more staff effort or were at risk for dropping out of the study in any one year. Race appeared to be associated with several measures of scheduling difficulty, while psychiatric characteristics of the sample were less so. 相似文献
Objective: Haemodialysis patients are at risk of serious health complications; yet, treatment non-adherence remains high. Warnings about health risks associated with non-adherence may trigger defensive reactions. We studied whether an intervention based on self-affirmation theory reduced resistance to health-risk information and improved fluid treatment adherence.
Design: In a cluster randomised controlled trial, 91 patients either self-affirmed or completed a matched control task before reading about the health-risks associated with inadequate fluid control.
Outcome measures: Patients’ perceptions of the health-risk information, intention and self-efficacy to control fluid were assessed immediately after presentation of health-risk information. Interdialytic weight gain (IDWG), excess fluid removed during haemodialysis, is a clinical measure of fluid treatment adherence. IDWG data were collected up to 12 months post-intervention.
Results: Self-affirmed patients had significantly reduced IDWG levels over 12 months. However, contrary to predictions derived from self-affirmation theory, self-affirmed participants and controls did not differ in their evaluation of the health-risk information, intention to control fluid or self-efficacy.
Conclusion: A low-cost, high-reach health intervention based on self-affirmation theory was shown to reduce IDWG over a 12-month period, but the mechanism by which this apparent behaviour change occurred is uncertain. Further work is still required to identify mediators of the observed effects. 相似文献