Behavioral and pharmacological modulation of respiration in rhesus monkeys.

Changes in respiration associated with schedule-controlled behavior were determined in seated rhesus monkeys prepared with a pressure-displacement head plethysmograph for monitoring ventilation continuously during behavioral experiments. Subjects were trained to press a lever under fixed-ratio 40 and fixed-interval 300-s schedules of stimulus termination. Episodic increases in ventilation were closely associated with periods of responding under both schedules. Recurring episodes of increased ventilation occurred during fixed-ratio responding, and were separated by brief 10-s timeouts during which ventilation decreased. Under the fixed-interval schedule, both ventilation and response rate typically increased as the 300-s interval elapsed. The effects of cocaine, caffeine, and two adenosine agonists, 5'-N-ethylcarboxamidadenosine (NECA) and 2-(carboxyethylphenylamino)adenosine-5'-carboxamide (CGS 21680), on behavior and respiration were determined using a cumulative-dosing procedure. Drug-induced suppression of behavior eliminated the episodic increases in ventilation during the performance components of both schedules. Schedule-related increases in ventilation were compared to those produced by elevated levels of CO2 in inspired air. Exposure to 4% CO2 mixed in air increased ventilation in all subjects, and the combined effects of CO2 exposure and schedule-controlled responding on respiration appeared to be additive. The results suggest that behavioral activities may increase ventilation through increased metabolic demand and increased CO2 production.     

Temporal discrimination learning of operant feeding in goldfish (Carassius auratus)

Operant temporal discrimination learning was investigated in goldfish. In the first experiment, there was a fixed daily change in illumination. Eight subjects were trained to operate a lever that reinforced each press with food. The period during which responses were reinforced was then progressively reduced until it was 1 hr in every 24. The final 1-hr feeding schedule was maintained over 4 weeks. The feeding period commenced at the same time each day throughout. The food dispensers were then made inactive, and a period of extinction ensued for 6 days. The pattern of responding suggested that the fish were able to exhibit temporal discrimination in anticipation of feeding time. This pattern of responding persisted for a limited number of days during the extinction procedure. The second experiment produced evidence that operant temporal discrimination could develop under continuous illumination.     

Discrimination of methadone and cocaine by pigeons without explicit discrimination training.

Pigeons were trained to peck a key on a variable-interval 2-min schedule of food reinforcement. Prior to each session, either 2.0 mg/kg methadone (n = 3), 3.0 mg/kg cocaine (n = 4), or 5.6 mg/kg cocaine (n = 2) was administered. When each pigeon's rate of pecking was stable, a range of doses of the training drug and saline were administered prior to 20-min extinction sessions separated by at least four training sessions. Rate of pecking during these extinction tests was generally an increasing function of dose, with the lowest rates obtained following saline and low doses and the highest rates obtained following doses near the training doses. Dose functions from pigeons trained with 5.6 mg/kg cocaine were steeper than those from pigeons trained with 3.0 mg/kg cocaine. Pigeons trained with methadone or 3.0 mg/kg cocaine were then given discrimination training, in which food reinforcement followed drug administration and 20-min extinction sessions followed saline administration. Rates of pecking under these conditions quickly diverged until near-zero rates were obtained following saline and high rates were obtained following drug. Discrimination training steepened dose functions for the training drugs, and the effects of several other substituted drugs depended on the pharmacology of the training drug. The pigeons trained with 5.6 mg/kg cocaine were tested with d-amphetamine, methadone, and morphine prior to discrimination training. d-Amphetamine increased rates dose dependently, and methadone and morphine did not. The results suggest that discriminative control by methadone and cocaine was established without explicit discrimination training.     

Detecting a nonevent: Delayed presence-versus-absence discrimination in pigeons

Eight pigeons were trained on a delayed presence-versus-absence discrimination paradigm in which a sample stimulus was presented on some trials but not on others. If a sample was presented, then a response to one choice key produced food. If no sample was presented, a response to the other choice key produced food. The basic finding was that performance remained constant and well above 50% correct on no-sample trials as the retention interval increased, whereas performance dropped precipitously (to below 50% correct) on sample trials. In the second phase of the experiment, all of the trials were no-sample trials, and reinforcers were delivered probabilistically for one group of pigeons and according to time-based schedules for the other group. The exact reinforcement probabilities used in Phase 2 were those calculated to be in effect on no-sample trials in Phase 1 (according to a discrete-state model of performance). Subjects did not show exclusive preference for the richer alternative on no-sample trials in the first phase, but those in the probabilistic group developed near-exclusive preference for the richer alternative during the second phase. These data are inconsistent with the predictions of the discrete-state model, but are easily accommodated by an account based on signal detection theory, which also can be applied effectively to discrimination of event duration and the “subjective shortening” effect.     

Infant auditory perception: Tonal masking

The results of an earlier study (Olsho, 1984) indicated that 5- to 8-month-old infants were relatively better at discriminating among high-frequency pitches than low. In the present study, sensory and nonsensory explanations for that effect were evaluated by examining infants' performance in a task requiring similar sensory processing but differing in the demands placed on processes such as memory. Infants' ability to resolve frequency was tested using a tonal masking paradigm, the psychophysical tuning curve. Twenty-four infants were tested at probe frequencies ranging from 500 to 4000 Hz; a group of young adults served as a comparison. Masked and unmasked thresholds were estimated using the visually reinforced head turn procedure in conjunction with an adaptive psychophysical method. Although infants' tuning curves fell below those of adults (indicating poorer performance), the widths and slopes of the infants' curves were not different from the adults'. Moreover, the difference between age groups remained constant across probe frequencies. These findings imply that by 5 months of age, the infant's ability to resolve sound frequency is similar to the adult's.     

Reaction times of pigeons on a wavelength discrimination task

After extensive pretraining, three pigeons were exposed in 2-second trials to a random series of 14 light wavelengths, ranging in one nanometer (nm) steps from 575 nanometers to 589 nanometers. Responses to one of the wavelengths, 582 nanometers, were intermittently reinforced. The relative frequency of response approached 1.0 at 582 nanometers, and decreased with progressively higher and lower wavelengths. Reaction times shorter than about 0.2 second occurred with a low frequency that was largely independent of wavelength. Wavelength controlled the frequency of longer reaction times, but did not affect the distribution of these reaction times. Consequently, receiver-operating characteristic curves constructed by using reaction time as a rating measure did not conform to the signal-detection model, in contrast to such conformity when response rate is used in a similar way. The data suggest that stimulus onset as such triggers early response emission with some small probability; the probability of responses with longer latency is controlled by wavelength, but their time of emission is controlled by some independent process.     

Variability of response location on fixed-ratio and fixed-interval schedules of reinforcement

Variability of response location was studied in monkeys performing in a six-lever chamber. Fixed-ratio schedules, ranging from FR 1 to FR 300, generated a high degree of stereotypy of response location. In contrast, fixed-interval schedules of comparable reinforcement frequencies (0.06 to 4 minutes) generated much greater variability. These results failed to confirm any simple relationship between response variability and intermittence of reinforcement. Rather, variability seems to be determined by the particular characteristics of the reinforcement schedule.     

Stimulus control of Pavlovian facilitation

Two experiments were conducted using an autoshaping procedure with pigeons to examine whether dimensional stimulus control by a Pavlovian facilitator parallels the control established following operant discrimination training. Facilitation training consisted of the presentation of a black vertical line on a white background as the B stimulus in a feature-positive discrimination in which the A stimulus (white keylight) was followed by grain presentation only if preceded by B. In this way, B facilitates or sets the occasion for pecking at A. Subsequent testing for generalization along the line-orientation dimension produced decremental gradients when the facilitation paradigm incorporated an explicit feature-negative stimulus (B−). These results parallel the decremental control obtained following operant discrimination training and suggest that Pavlovian facilitators and instrumental discriminative stimuli are functionally equivalent.     

Behavioral economics of drug self-administration. II. A unit-price analysis of cigarette smoking.

In behavioral economics, the ratio of response requirement to reinforcer magnitude is referred to as unit price. Previous research with nonhuman subjects has demonstrated that (a) comparable amounts of food are consumed at the same unit price even though different response requirements and reinforcer magnitudes comprise that unit price and (b) increases in unit price decrease food consumption in a positively decelerating fashion. The present study assessed the generality of these findings to the cigarette smoking of 5 human volunteers. During approximately 18 3-hr sessions, various combinations of response requirement (fixed-ratio 200, 400, and 1,600) and reinforcer magnitude (1, 2, and 4 puffs per bout) were arranged. Consumption (i.e., the number of puffs) generally was comparable at the same unit price independent of the response requirement and reinforcer magnitude comprising that unit price. In addition, increasing unit price generally decreased consumption in a positively decelerating fashion. These results extend the generality of the unit-price analysis to human cigarette smoking. Moreover, these results further support the position that reinforcer magnitude and response requirement are functionally equivalent and interact to determine consumption. The concept of unit price, by integrating and summarizing the effects of those two operations, provides a more parsimonious explanation of the results than do separate evaluations of the effects of response requirement and reinforcer magnitude.     

CONDITIONAL DISCRIMINATION VS. MATCHING TO SAMPLE: AN EXPANSION OF THE TESTING PARADIGM

A subject's performance under a conditional-discrimination procedure defines conditional relations between stimuli: “If A1, then B1; if A2, then B2.” The procedure may also generate matching to sample. If so, the stimuli will be related not only by conditionality, but by equivalence: A1 and B1 will become equivalent members of one stimulus class, A2 and B2 of another. One paradigm for testing whether a conditional-discrimination procedure has generated equivalence relations uses three sets of stimuli, A, B, and C, three stimuli per set. Subjects learn to select Set-B and Set-C comparisons conditionally upon Set-A samples. Having been explicitly taught six sample-comparison relations, A1B1, A1C1, A2B2, A2C2, A3B3, and A3C3, subjects prove immediately capable of matching the B- and C-stimuli; six new relations emerge (B1C1, B2C2, B3C3, C1B1, C2B2, C3B3). The 12 stimulus relations, six taught and six emergent, define the existence of three three-member stimulus classes, A1B1C1, A2B2C2, and A3B3C3. This paradigm was expanded by introducing three more stimuli (Set D), and teaching eight children not only the AB and AC relations but DC relations also—selecting Set-C comparisons conditionally upon Set-D samples. Six of the children proved immediately capable of matching the B- and D-stimuli to each other. By selecting appropriate Set-B comparisons conditionally upon Set-D samples, and Set-D comparisons conditionally upon Set-B samples, they demonstrated the existence of three four-member stimulus classes, A1B1C1D1, A2B2C2D2, and A3B3C3D3. These larger classes were confirmed by the subjects' success with the prerequisite lower-level conditional relations; they were also able to select Set-D comparisons conditionally upon samples from Sets A and C, and to do the BC and CB matching that defined the original three-member classes. Adding the three DC relations therefore generated 12 more, three each in BD, DB, AD, and CD. Enlarging each class by one member brought about a disproportionate increase in the number of emergent relations. Ancillary oral naming tests suggested that the subject's application of the same name to each stimulus was neither necessary nor sufficient to establish classes of equivalent stimuli.