Using the hippocampal-slice preparation, we attempted to model operant conditioning in vitro by reinforcing pyramidal cell bursting responses with local micropressure applications of transmitters and drugs. The same injections were administered independently of bursting to provide a "noncontingent" control for direct pharmacological stimulation or facilitation of firing. The results suggested that the bursting responses of individual CA1 pyramidal neurons may be reinforced in a dose-related manner by response-contingent (but not noncontingent) injections of dopamine and the selective dopamine D2 agonist, N-0923. N-0924, a stereoisomer of N-0923 that is largely devoid of D2-agonist activity, failed to reinforce CA1 bursting. Burst-contingent injections of the excitatory neurotransmitter glutamate also failed to reinforce CA1 bursting; indeed, the glutamate applications (whether contingent or random) reduced the likelihood of bursts while increasing the frequency of solitary spikes. Reinforcement delays exceeding 200 ms largely eliminated the reinforcing efficacy of the D2 agonist N-0437 in CA1 operant conditioning. The results are consistent with the suggestion that the behaviorally reinforcing effects of dopaminergic agents can be modeled in vitro in the hippocampal-slice preparation. 相似文献
The objective of the study was to investigate the validity of IAT in the assessment of the Big five personality traits. We employed the Multi-Trait Multi-Method (MTMM) approach on a sample of 146 respondents. We collected measures on IATs assessing Big five personality traits, self-reports, and two ratings of close others of different gender on NEO PI-R. Additionally, we assessed behavior related to the Big five personality traits in a structured interview where three experts independently provided rating measures. MTMM analyses suggest that personality IAT measures have little in common with personality traits measured traditionally using explicit methods. The evidence does not support the claim that personality IAT can serve as a valid measure of individual differences in personality traits. 相似文献
Digitalization and the development of Artificial Intelligence (AI) will bring about substantial changes in all aspects of life. This happens in a world marked by the poisonous synergy of five Ps, polarization, populism, protectionism, post‐truth, patriarchy, as well as an ambiguous interplay of secularization and new visibility of religion. If development of AI is to be beneficial for people and planet a number of challenges must be met. In this regard, religion‐and‐science dialogue needs improvement in making things not only intellectually but also spiritually fit. Ethics should be involved from the beginning rather than being called upon first when problems arise. Faith communities have a prophetical, diaconal, ethical, and theological role. Based on the characterization of life as a fourfold web of relationality, personal, social, political, as well as global issues are identified and discussed. These include mental health disorders, addiction, manipulation, and self‐exploitation. Reflections on leadership suggest resilience, coexistence, and hope as theological key components for navigating the uncharted realms of the digital age. 相似文献
Associations between personality and health may be influenced by contextual factors varying across studied cohorts. Moreover, measurement bias related to contextual factors could also influence these associations. Gender and age have been discussed as important contextual factors when studying personality and health outcomes. An examination of measurement invariance across gender and age may therefore be warranted. In the present study, measurement invariance across age and gender was examined for a five-factor model of personality traits in which scales have been included to operationalise lower-order traits related to health-behaviour or health outcomes. Using multi-group confirmatory factor analysis on a population based cohort (n= 5700), all important parameters of the measurement model were found to be invariant. On the basis of this invariant model, hypotheses of mean differences across age and gender in personality traits were tested. These results were discussed in relation to meta-analyses on personality change and gender differences in personality. 相似文献
In this article we deal with Glivenko type theorems for intuitionistic modal logics over Prior's MIPC. We examine the problems which appear in proving Glivenko type theorems when passing from the intuitionistic propositional logic Intto MIPC. As a result we obtain two different versions of Glivenko's theorem for logics over MIPC. Since MIPCcan be thought of as a one-variable fragment of the intuitionistic predicate logic Q-Int, one of the versions of Glivenko's theorem for logics over MIPCis closely related to that for intermediate predicate logics obtained by Umezawa [27] and Gabbay [15]. Another one is rather surprising. 相似文献
Objective: This study explored cross-time associations between personality and multiple components of sexual functioning and behaviour in a large cohort of older adults (n = 5745).
Design: Participants (Mage = 65.57 ± 8.28 years) completed questionnaires in 2010 and 2012.
Main outcome measures: Outcomes explored included sexual attitudes, sexual activity, sexual satisfaction, lifetime sexual partners, sexual orientation and sexual dysfunction.
Results: We found that higher levels of openness and lower levels of agreeableness were related to more liberal attitudes toward sex, a greater number of sexual partners, a higher sex drive, more frequent sexual activity, lower levels of sexual dysfunction and (for women) a greater tendency towards homosexuality. Higher levels of conscientiousness were also related to more conservative attitudes towards sex, lower levels of sexual dysfunction and a greater tendency towards heterosexuality. For sexually active older adults, higher levels of extraversion and lower levels of neuroticism were related to greater sexual satisfaction. Higher levels of extraversion and lower levels of conscientiousness were also related to a greater number of sexual partners in men but not women.
Conclusion: These findings provide evidence that personality is an important correlate of sexual functioning and behaviour in older adults. 相似文献