Extinction-induced "despair" in the water maze, exploratory behavior and fear: effects of chronic antidepressant treatment

In former studies, we found evidence for the hypothesis that withdrawal of negative reinforcement presents a major source for stress and despair. Specifically, the removal of a hidden platform in the water maze induced extinction of previously reinforced escape behavior and behavioral immobility, indicative of "despair", which also correlated with indices of fear. Here, we tested the effects of antidepressants on extinction in the water maze, and expected that such drugs would attenuate the rate of extinction of a conditioned place preference (CPP) and also any emotionally relevant behavior that is induced by the loss of reinforcement, such as immobility. Adult male Wistar rats were trained to escape onto a hidden platform for 10 days. Daily treatment with desipramine hydrochloride (DMI, 10mg/kg) or fluoxetine (FLX, 10 mg/kg) commenced 1 day before the first of 11 extinction trials without the platform, administered 48 h apart, and continued thereafter, as the rats were tested in an open field and elevated-plus maze. As compared to controls, DMI increased the resistance-to-extinction of CPP, attenuated immobility, and increased wall climbing behavior. In the open field, DMI reduced activity levels, but was without effect on traditional fear parameters in the elevated-plus maze. FLX, by contrast, increased immobility during the extinction trials and fear in the elevated-plus maze. The withdrawal of reinforcement induced "despair" that was alleviated by the noradrenaline reuptake inhibitor DMI. The effects of the selective serotonin reuptake inhibitor FLX on immobility and fear may be explained in terms of its side effect profile.     

语言和音乐中短语边界的认知加工

综述了近年来语言和音乐中有关短语边界加工的一些研究成果。首先,语言中使用事件相关电位技术（ERP）进行的众多研究表明,口语中的语调短语边界和阅读中的逗号都能诱发中止正漂移（CPS）这种反映语调短语中止的ERP成分。然后介绍了近期关于音乐短语结构的一系列ERP和事件相关磁场（ERF）研究,结果发现在各种实验条件下音乐CPS都能够稳定产生。最后,对今后汉语韵律层级结构边界的认知加工研究做出展望     

汉语同形歧义词歧义消解的两半球差异

实验探讨汉语同形歧义词(homographs)歧义消解的过程及大脑两半球的差异。被试为华中科技大学96名大学生,实验采用词汇判断任务。句子语境呈现在被试的视野中央,探测词在SOA(stimulus onset asynchronism)为100毫秒或400毫秒时呈现在左视野或右视野。结果发现,(1)当SOA为100毫秒时,在左视野(右半球)上,与语境一致的同形歧义词的主要意义得到激活,与语境不一致的次要意义也有一定程度的激活。在右视野(左半球)上,只有与语境一致的同形歧义词的主要意义得到激活。(2)当SOA为400毫秒时,在左、右视野(两半球)上,与语境一致的同形歧义词的主要意义和次要意义都得到激活。结果表明,大脑左半球对汉语歧义词的歧义消解具有一定的优势,语境敏感模型可以较好地解释本实验的结果。     

运动觉、布局无关运动与路径整合

路径整合是空间导航的一个重要子领域。本研究采用了一种三角形完成任务的新变式来研究路径整合问题，发现在剥夺被试的视觉输入的前提下，去除被试部分运动觉后，其绩效有不同水平的下降；同时还发现在编码过程中与路径布局无关的不同方向旋转间并无显著性差异。此外，由于本研究是在室外空间中所做的现场研究，故得到的结果优于室内所做的经典研究，进而验证了前人的一个猜测。     

目标数量与运动框架旋转角度对不同场认知风格个体多目标追踪表现的影响

通过改变目标数量、运动框架突变旋转角度探究不同场认知风格被试在多目标追踪任务中的表现。结果发现：(1)在任务难度较低(运动参考框架稳定, 目标数量为3和4)和任务难度中等(运动参考框架突变向右旋转20°, 目标数量为4)条件下, 场独立型被试的多目标追踪表现均显著好于场依存型被试。在任务难度较高(运动框架稳定, 目标数量为5以及运动参考框架突变向右旋转40°, 目标数量为4)条件下, 两组被试差异不显著。表明不同场认知风格被试追踪表现受任务难度影响; (2)随着目标数量由3至5增多, 追踪负荷增大使被试的追踪成绩显著下降; (3)相比运动框架稳定, 运动框架向右突变旋转20°和40°均显著削弱了被试的追踪表现。旋转角度变化破坏了场景连续性, 影响了追踪表现。     

Hemispheric asymmetries in meaning selection: Evidence from the disambiguation of homophonic vs. heterophonic homographs

Research investigating hemispheric asymmetries in meaning selection using homophonic homographs (e.g., bank), suggests that the left hemisphere (LH) quickly selects contextually relevant meanings, whereas the right hemisphere (RH) maintains a broader spectrum of meanings including those that are contextually irrelevant (e.g., Faust & Chiarello, 1998). The present study investigated cerebral asymmetries in maintaining the multiple meanings of two types of Hebrew homographs: homophonic homographs and heterophonic homographs (e.g., tear). Participants read homographs preceded by a biasing, or a non-biasing sentential context, and performed a lexical decision task on targets presented laterally, 1000 ms after the onset of the sentence-final ambiguous prime. Targets were related to either the dominant or the subordinate meaning of the preceding homograph, or unrelated to it. When targets were presented in the LVF/RH, dominant and subordinate meanings, of both types of homographs, were retained only when they were supported by context. In a non-biasing context, only dominant meanings of homophonic homographs were retained. Alternatively, when targets were presented in the RVF/LH, priming effects for homophonic homographs were only evident when meanings were supported by both context and frequency (i.e., when context favored the dominant meaning). In contrast, heterophonic homographs resulted in activation of dominant meanings, in all contexts, and activation of subordinate meanings, only in subordinate-biasing contexts. The results challenge the view that a broader spectrum of meanings is maintained in the right than in the left hemisphere and suggest that hemispheric differences in the time course of meaning selection (or decay) may be modulated by phonology.     

Models provide specificity: Testing a proposed mechanism of visual working memory capacity development

Numerous studies have established that visual working memory has a limited capacity that increases during childhood. However, debate continues over the source of capacity limits and its developmental increase. Simmering (2008) adapted a computational model of spatial cognitive development, the Dynamic Field Theory, to explain not only the source of capacity limitations but also the developmental mechanism. Capacity is limited by the balance between excitation and inhibition that maintains multiple neural representations simultaneously in the model. Development occurs according to the Spatial Precision Hypothesis, which proposes that excitatory and inhibitory connections strengthen throughout early childhood. These changes in connectivity result in increasing precision and stability of neural representations over development. Here we test this developmental mechanism by probing children's memory in a single-item change detection task. Results confirmed the model's predictions, providing further support for this account of visual working memory capacity development.     

Evidence for perceptual learning with repeated stimulation after partial and total cortical blindness

Lesions of occipital cortex result in loss of sight in the corresponding regions of visual fields. The traditional view that, apart from some spontaneous recovery in the acute phase, field defects remain permanently and irreversibly blind, has been challenged. In patients with partial field loss, a range of residual visual abilities in the absence of conscious perception (blindsight) has been demonstrated (Weiskrantz, 1986). Recent findings (Sahraie et al., 2006, 2010) have also demonstrated increased visual sensitivity in the field defect following repeated stimulation. We aimed to extend these findings by systematically exploring whether repeated stimulation can also lead to increased visual sensitivity in two cases with total (bilateral) cortical blindness. In addition, for a case of partial blindness, we examined the extent of the recovery as a function of stimulated region of the visual field, over extended periods of visual training. Positive auditory feedback was provided during the training task for correct detection of a spatial grating pattern presented at specific retinotopic locations using a temporal two alternative forced-choice paradigm (Neuro-Eye Therapy). All three cases showed improved visual sensitivity with repeated stimulation. The findings indicate that perceptual learning can occur through systematic visual field stimulation even in cases of bilateral cortical blindness.     

Pro‐Diversity Beliefs and Everyday Ethnic Discrimination on Grounds of Foreign Names

The paper examined the effect of positive beliefs about the value of ethnic diversity (i.e. diversity beliefs) on discrimination due to foreign sounding names. It was hypothesized that pro‐diversity beliefs reduce discrimination. Results from two studies (N = 29 and N = 104) confirmed this hypothesis. Practical implications of our results are discussed. Copyright © 2013 John Wiley & Sons, Ltd.     

Field and Experience Influences on Ethical Decision Making in the Sciences

Differences across fields and experience levels are frequently considered in discussions of ethical decision making and ethical behavior. In the present study, doctoral students in the health, biological, and social sciences completed measures of ethical decision making. The effects of field and level of experience with respect to ethical decision making, metacognitive reasoning strategies, social-behavioral responses, and exposure to unethical events were examined. Social and biological scientists performed better than health scientists with respect to ethical decision making. Furthermore, the ethical decision making of health science students decreased as experience increased. Moreover, these effects appeared to be linked to the specific strategies underlying participants' ethical decision making. The implications of these findings for ethical decision making are discussed.