预期错误在恐惧记忆更新中的作用与机制

依据错误驱动的学习理论,行为预期结果与实际结果之间的不匹配即预期错误(Predictionerror,PE)是学习产生的驱动因素。作为显著性信息中的一种,预期错误和物理显著性、惊讶、新异性等存在信息加工阶段的不同,与记忆更新的关系也有差异。近年来,记忆再巩固干预范式(reconsolidation interference)被证明可用于人类条件性恐惧记忆的更新,其中记忆提取激活阶段所包含的预期错误起到了引发记忆“去稳定”、开启记忆再巩固的关键作用。在促进恐惧记忆更新的行为机制上,PE被认为是记忆去稳定的必要非充分条件。记忆提取必须包含适量的PE,但其引发的是记忆去稳定、消退还是中间状态,还需结合记忆本身性质确定。在促进恐惧记忆更新的神经机制上,杏仁核、导水管周围灰质(PAG)、海马均在PE探测和计算过程中具有重要作用;前额叶皮层(PFC)及其亚区在PE开启记忆再巩固过程中扮演了重要角色。上述过程又受到神经系统中特定神经递质的重要调节,尤其是多巴胺能和谷氨酸能。未来研究应进一步探索基于PE计算模型的量化研究,整合PE与其他边界条件的交互作用,考察不同类型显著性在记忆再巩固中的作用等;并亟...     

Fear Appeals Revisited: Testing a Unique Anti-smoking Film

Past research has found that fear-arousing persuasive messages can significantly affect attitudes, intentions, and behaviors. In this study, participants in high and low threat conditions viewed appropriately edited versions of a unique fear appeal video used in the American Lung Association’s anti-smoking campaign, while control condition participants viewed no film. Threat condition participants expressed stronger anti-smoking behavioral intentions than did control condition participants. These results represent the first effectiveness test of this widely used film.     

‘It's gotten a bit old,charity’: Young adults in New Zealand talk about poverty,charitable giving and aid appeals

An extensive body of literature exists on the phenomena of poverty, charitable giving and the effectiveness of aid appeals. To date psychological research has predominantly focused on individualistic models to explain people's understandings of poverty and their charitable giving practices. Based upon a social constructionist epistemology, this study investigates how understandings of aid appeals, poverty and charitable giving are discursively produced and constructed in relation to one another through an analysis of New Zealand young adults' talk about these issues. Data were collected from three focus group discussions among pre‐existing friendship groups comprising three male and nine female students aged between 18 and 25. A brief video clip of aid appeals was used to stimulate discussion on poverty and charitable giving. Analysis of these discussions revealed three discursive themes relating to the aid appeals: local versus international need, emotional arousal and insufficient information. Drawing upon these themes the participants constructed poverty as relative or extreme, and largely explained by educational deficits. They constructed charitable giving as solicited through aid appeals, as compromised through immunity to such appeals, and as diminished through positionings of self‐help and self‐responsibility. These discursive constructions were drawn on by participants to legitimate their own non‐donor position. Copyright © 2008 John Wiley & Sons, Ltd.     

条件性恐惧大鼠边缘下区Cdk5激酶活性、caspase-3表达以及突触结构的变化

探讨条件性恐惧大鼠内侧前额叶皮层边缘下区(IL区)Cdk5激酶活性、凋亡因子caspase-3表达和突触结构的变化。采用声音结合足底电击的方法对大鼠建立条件性恐惧模型后, 在不同时间点测定IL区Cdk5激活剂P35和P25的蛋白表达水平、Cdk5激酶活性、caspase-3的阳性细胞数, 并观察突触结构的变化。结果发现, 大鼠在条件性恐惧建立后第2、4和8天, IL区的P25蛋白表达和Cdk5激酶活性均明显高于正常; caspase-3的免疫反应阳性细胞数在3个时间点也均多于正常; 透射电镜下观察到：在恐惧建立后的第8天, IL区突触的突触后致密物质(PSD)厚度变薄, 在恐惧建立后第22天突触数密度减少、PSD厚度仍小于正常。推测条件性恐惧的建立, 使大鼠IL区的P25水平和Cdk5活性高于正常, 引起IL区的突触结构发生改变, 导致大鼠的恐惧反应持续存在。     

Cognitive Links Between Fear Of Failure And Perfectionism

This study investigated links between three forms of perfectionism and beliefs associated with fear of failure (FF). College students (N = 372) enrolled in physical activity classes completed the Multidimensional Perfectionism Scale and Performance Failure Appraisal Inventory in a single session. After controlling for other forms of perfectionism, only socially prescribed perfectionism (SPP) was strongly associated with beliefs that failure led to aversive interpersonal consequences (i.e., important others losing interest, upsetting important others). Other-oriented perfectionism (OOP) exhibited a weak negative relation with beliefs that failure would lead to devaluation of one’s self-estimate; individuals who held the highest standards for others’ behavior had the weakest beliefs that failure would lead to them devaluing their self-estimate. Self-oriented perfectionism (SOP) was not associated with any beliefs that failure led to aversive consequences; however, when SOP and OOP were simultaneously elevated, they contributed positively to fears of experiencing shame and embarrassment (above and beyond main effects of SPP). Collectively these findings indicated that FF was not ubiquitous with all forms of perfectionism because the specific beliefs about the consequences of failure that underlie different forms of perfectionism varied tremendously. This research was supported in part by a grant from the College of Health & Human Development, The Pennsylvania State University.     

Diagnostic Features,Symptom Severity,and Help-Seeking in a Media-Recruited Sample of Women with Driving Fear

This paper examines the clinical features, symptom severity, diagnostic profile, and help-seeking behaviour of a media-recruited sample of driving-fearful women. Results support previous findings of the primary foci of fear as motor vehicle accidents as well as specific driving situations and conditions. Consistent with prior research, there was difficulty relating the foci of fear to current diagnostic concepts. Social concerns were identified as having a role in driving fear for some individuals. Fearful participants exhibited high levels of fear and symptom severity according to various diagnostic and self-report measures, although most reported that they would be unlikely to seek professional psychological help or driving instruction. Assessment of cognitions indicated a range of errors likely to maintain anxiety and fear reactions that would be a target of treatment. There were no group differences in number of major recent accidents, although fearful drivers learnt to drive later than controls, suggesting early fearfulness.

Driving fear and driving skills: comparison between fearful and control samples using standardised on-road assessment

The present study explores driving skills in a group of 50 media-recruited driving-fearful and 50 control drivers, all of whom were women. Participants completed an on-road practical driving assessment with a professional driving instructor. Diagnostic as well as pre-post self-report and instructor driving assessments were conducted. Fearful drivers made more errors on the driving assessment than controls. However, the pattern of errors was identical for both groups, indicating that fear and anxiety may be associated with the number rather than the type of driving errors made. These differences remained when factors such as driving history, current driving frequency, and diagnosis were controlled using case selection. More research is needed to replicate the findings in more diverse samples. Additional work should also aim to clarify the specific role of driving skills in driving fear, which will facilitate treatment planning for exposure-based treatments and help identify cases where driving skills assessment may be appropriate.     

睡眠对恐惧学习的影响及其认知神经机制

睡眠问题可能会诱发恐惧相关情绪障碍(焦虑、创伤性应激障碍、恐怖症等),研究睡眠影响恐惧学习的认知神经机制,有助于增强对恐惧相关情绪障碍的预测、诊断和治疗。以往研究表明睡眠剥夺影响恐惧习得和消退主要是通过抑制vmPFC活动,阻碍其与杏仁核的功能连接,从而导致恐惧习得增强或是消退学习受损。进一步研究发现睡眠不同阶段对恐惧学习相关脑区有独特的影响:剥夺(缺乏)快速眼动睡眠会抑制vmPFC活动、增强杏仁核、海马激活,导致恐惧习得增强,消退学习受损,此外边缘皮层的功能连接减少破坏了记忆巩固(恐惧记忆和消退记忆);而慢波睡眠主要与海马变化有关,慢波睡眠期间进行目标记忆重激活可促进恐惧消退学习。未来研究需要增加睡眠影响恐惧泛化的神经机制研究、及昼夜节律中断对恐惧消退的影响,以及关注动物睡眠研究向人类睡眠研究转化中存在的问题。     

Interrelationships between spider fear associations,attentional disengagement and self-reported fear: A preliminary test of a dual-systems model

Recent conceptualisations of anxiety posit that equivocal findings related to the time-course of disengaging from threat-relevant stimuli may be attributable to individual differences in associative and rule-based processing. The current study was designed to test the hypothesis that strength of spider-fear associations would indirectly predict reported spider fear via impaired disengagement. One hundred and thirty-one undergraduate volunteer participants completed the Go/No-go Association Task, a visual search task, and self-report spider fear questionnaires. Stronger spider-fear associations were associated with reduced disengagement accuracy, whereas higher levels of reported spider fear were related to faster engagement with and disengagement from spiders. Bootstrapping multiple mediation analyses demonstrated that stronger-spider fear associations evidenced an indirect relationship with reported spider fear via reduced disengagement accuracy, highlighting the importance of fine-grained analyses of different aspects of cognitive bias. Results are discussed in terms of cognitive models of anxiety.     

A Greek-Language Inventory of Fears: Psychometric Properties and Factor Structure of Self-Reports of Fears on the Hellenic Fear Survey Schedule

The structure of fearfulness and the psychometric properties of a Greek-language version of the Fear Survey Schedule were studied in a sample of normal Greek adults. Overall summary scores were higher for women than for men, had satisfactory temporal stability and internal consistency, and were useful in discriminating levels of phobic anxiety independent of levels of depression as assessed by a concurrent self-report measure. However, the temporal stabilities of responses for many items were inadequate for the reliable identification of levels of fear of specific events and objects. A factor analysis yielded five components that were conceptually similar to those obtained abroad. Subscales based on component items were psychometrically reliable. In comparison with American subjects, Greek subjects rated similar items as most fearful, but reported higher levels of fears of these items, reflecting either higher levels of fears, greater disclosure, or cultural differences in the meaning of fear ratings.