条件性恐惧大鼠边缘下区Cdk5激酶活性、caspase-3表达以及突触结构的变化

探讨条件性恐惧大鼠内侧前额叶皮层边缘下区(IL区)Cdk5激酶活性、凋亡因子caspase-3表达和突触结构的变化。采用声音结合足底电击的方法对大鼠建立条件性恐惧模型后, 在不同时间点测定IL区Cdk5激活剂P35和P25的蛋白表达水平、Cdk5激酶活性、caspase-3的阳性细胞数, 并观察突触结构的变化。结果发现, 大鼠在条件性恐惧建立后第2、4和8天, IL区的P25蛋白表达和Cdk5激酶活性均明显高于正常; caspase-3的免疫反应阳性细胞数在3个时间点也均多于正常; 透射电镜下观察到：在恐惧建立后的第8天, IL区突触的突触后致密物质(PSD)厚度变薄, 在恐惧建立后第22天突触数密度减少、PSD厚度仍小于正常。推测条件性恐惧的建立, 使大鼠IL区的P25水平和Cdk5活性高于正常, 引起IL区的突触结构发生改变, 导致大鼠的恐惧反应持续存在。     

Temperament and Psychopathy: A Dual-Pathway Model

ABSTRACT— The concept of psychopathy refers to a pattern of chronic antisocial behavior and personality features, such as emotional detachment, lovelessness, and guiltlessness, attributable in part to a temperament deficit. Historically, that deficit has been seen as a low reactivity to fear, but recent research has documented a second temperament deficit in adults that involves poor emotional and behavioral control. Both pathways are found in the child psychopathology literature, pointing to multifactorial developmental pathways from childhood to adult psychopathy.     

TRANSFER OF AVERSIVE RESPONDENT ELICITATION IN ACCORDANCE WITH EQUIVALENCE RELATIONS

The present study investigates the transfer of aversively conditioned respondent elicitation through equivalence classes, using skin conductance as the measure of conditioning. The first experiment is an attempt to replicate Experiment 1 in Dougher, Augustson, Markham, Greenway, and Wulfert (1994), with different temporal parameters in the aversive conditioning procedure employed. Match‐to‐sample procedures were used to teach 17 participants two 4‐member equivalence classes. Then, one member of one class was paired with electric shock and one member of the other class was presented without shock. The remaining stimuli from each class were presented in transfer tests. Unlike the findings in the original study, transfer of conditioning was not achieved. In Experiment 2, similar procedures were used with 30 participants, although several modifications were introduced (formation of five‐member classes, direct conditioning with several elements of each class, random sequences of stimulus presentation in transfer tests, reversal in aversive conditioning contingencies). More than 80% of participants who had shown differential conditioning also showed the transfer of function effect. Moreover, this effect was replicated within subjects for 3 participants. This is the first demonstration of the transfer of aversive respondent elicitation through stimulus equivalence classes with the presentation of transfer test trials in random order. The latter prevents the possibility that transfer effects are an artefact of transfer test presentation order.     

Diagnostic Features,Symptom Severity,and Help-Seeking in a Media-Recruited Sample of Women with Driving Fear

This paper examines the clinical features, symptom severity, diagnostic profile, and help-seeking behaviour of a media-recruited sample of driving-fearful women. Results support previous findings of the primary foci of fear as motor vehicle accidents as well as specific driving situations and conditions. Consistent with prior research, there was difficulty relating the foci of fear to current diagnostic concepts. Social concerns were identified as having a role in driving fear for some individuals. Fearful participants exhibited high levels of fear and symptom severity according to various diagnostic and self-report measures, although most reported that they would be unlikely to seek professional psychological help or driving instruction. Assessment of cognitions indicated a range of errors likely to maintain anxiety and fear reactions that would be a target of treatment. There were no group differences in number of major recent accidents, although fearful drivers learnt to drive later than controls, suggesting early fearfulness.

Cognitive Links Between Fear Of Failure And Perfectionism

This study investigated links between three forms of perfectionism and beliefs associated with fear of failure (FF). College students (N = 372) enrolled in physical activity classes completed the Multidimensional Perfectionism Scale and Performance Failure Appraisal Inventory in a single session. After controlling for other forms of perfectionism, only socially prescribed perfectionism (SPP) was strongly associated with beliefs that failure led to aversive interpersonal consequences (i.e., important others losing interest, upsetting important others). Other-oriented perfectionism (OOP) exhibited a weak negative relation with beliefs that failure would lead to devaluation of one’s self-estimate; individuals who held the highest standards for others’ behavior had the weakest beliefs that failure would lead to them devaluing their self-estimate. Self-oriented perfectionism (SOP) was not associated with any beliefs that failure led to aversive consequences; however, when SOP and OOP were simultaneously elevated, they contributed positively to fears of experiencing shame and embarrassment (above and beyond main effects of SPP). Collectively these findings indicated that FF was not ubiquitous with all forms of perfectionism because the specific beliefs about the consequences of failure that underlie different forms of perfectionism varied tremendously. This research was supported in part by a grant from the College of Health & Human Development, The Pennsylvania State University.     

Driving fear and driving skills: comparison between fearful and control samples using standardised on-road assessment

The present study explores driving skills in a group of 50 media-recruited driving-fearful and 50 control drivers, all of whom were women. Participants completed an on-road practical driving assessment with a professional driving instructor. Diagnostic as well as pre-post self-report and instructor driving assessments were conducted. Fearful drivers made more errors on the driving assessment than controls. However, the pattern of errors was identical for both groups, indicating that fear and anxiety may be associated with the number rather than the type of driving errors made. These differences remained when factors such as driving history, current driving frequency, and diagnosis were controlled using case selection. More research is needed to replicate the findings in more diverse samples. Additional work should also aim to clarify the specific role of driving skills in driving fear, which will facilitate treatment planning for exposure-based treatments and help identify cases where driving skills assessment may be appropriate.     

Fear of Failure Biases Affective and Attentional Responses to Lexical and Pictorial Stimuli

The purpose of this investigation was to examine whether attentional biases would be noticed among individuals differing in levels of fear of failure (FF) as they viewed pictorial and lexical stimuli depicting various affective content. Indices of natural selective attention, namely, viewing time and self-reported affect, were assessed in 137 college students during free viewing picture and word presentation conditions. As hypothesized, FF was (a) negatively associated with self-reported dominance and valence for failure- and unpleasant-themed stimuli, and (b) positively associated with arousal ratings for unpleasant pictures. Although initially suppressed by neuroticism, partial correlation coefficients revealed a significant positive relationship between FF and viewing time for failure pictures. Results are discussed in the context of current theories of emotional reactivity and attentional biases pertaining to the nature of FF. Recommendations are provided for future research to elaborate the mechanisms involved in detrimental effects of FF.     

Masculinity and Emotionality: An Investigation of Men's Primary and Secondary Emotional Responding

In this study, we investigated the role of masculinity in men's affect intensity and men's fear of emotions. Men's masculine ideology and self-reported masculine gender role stress were assessed as cognitive and experiential factors of adherence to traditional masculine gender norms. Masculine ideology was negatively related to men's global affect intensity. However, on a 3-factor model of affect intensity, only negative reactivity was significantly related to masculine ideology. Both masculine ideology and masculine gender role stress were positively related to men's fear of emotions. Results are discussed in the context of theories of gender differences in emotion.     

TERMINATION OF A FE/MALE TRANSSEXUAL PATIENT'S ANALYSIS: AN EXAMPLE OF GENERAL VALIDITY

The author describes the termination of an analysis, which, while relating to the particular case of a male-to-female transsexual patient, may be relevant to all analysts, particularly those whose patients need to integrate disavowed and split-off parts of themselves. The patient had undergone sex-change surgery at the age of 20. Having lived as a woman thereafter, she had asked for analysis some twenty years later. The author, who discussed the first three years of that analysis in an earlier paper, as well as her hesitation about undertaking it, considers that its termination after seven years illustrates not only the specific problems posed by transsexuals but also the general ones presented by 'heterogeneous patients'. To the best of her knowledge, this is the first published case history of a transsexual patient who has undergone surgery. In the author's view, the patient has acquired a new sense of internal unity based on a notion of sex differentiation in which mutual respect between the sexes has replaced confusion and mutual hate, and her quality of life has improved. On the general level, this termination shows how the reduction of paranoid-schizoid anxieties and the reintegration of split-off parts of the personality lead, as the depressive position is worked through, to a better toleration of internal contradictions, a new sense of cohesion of the self and a diminution of the fear of madness.     

JUMPING FROM THE COUCH

This paper addresses two questions: first, how do phantasies work? Second, how do these mental activities affect a person's overall emotional life? The first question tends to be overlooked since those who accept, for example, projective identification as a basic mental activity tend also to treat it as an explanatory primitive. On this view, there is no further question to ask about how projective identification itself works; rather, other psychological and emotional phenomena are explained in terms of it. By contrast, this paper asks, how does projective identification itself work? The aim is not to provide a reductive explanation but to ask how it is that phantasies have the efficacy they have. To that end, one moment in the analysis of the Rat Man is re‐examined. There is then an attempt to show the difficulties involved in weaving an account of phantasy into the broader‐scale interpretation of emotional life.