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851.
从进化发育角度反思免疫有关问题 总被引:2,自引:1,他引:1
从进化和发育角度对免疫学领域中某些尚未明了的有关问题及其生物学意义进行了反思。认为淋巴免疫源于脊椎动物机体阶段或变态发育的同步监管功能,它可区分幼体细胞/成体细胞或处理"异步"细胞以防止异常或逆行发育;协同刺激信号分子可能是细胞逆行发育的标志,而MHC分子可能是发育或变态的阶段标志;抗原受体多样性和MHC分子多态性的最初进化压力来自阶段发育中所需的自身识别,免疫的非我识别源于系统发育中积累的自我识别在个体内的冗余;复杂和难以理解的免疫现象可能只是由简单的进化机制形成的。 相似文献
852.
853.
Nathan A. Heflick Jamie L. Goldenberg Elisa Puvia 《Journal of experimental social psychology》2011,47(3):572-581
Most literally, objectification refers to perceiving a person as an object, and consequently, less than fully human. Research on perceptions of humanness and the stereotype content model suggests that humanness is linked to perceptions of warmth, morality and competence. Merging these insights with objectification theory, we hypothesized that focusing on a woman's, but not a man's, appearance should induce objectification, and thus reduce perceptions of these characteristics. In three studies, females, but not males, were perceived as less competent (Studies 2 and 3) and less warm and moral (Studies 1, 2 and 3) when participants were instructed to focus on their appearance. These findings support our position and help rule out stereotype activation as an alternative explanation to dehumanization. Further, they generalized to targets of different races, familiarity, physical attractiveness and occupational status. Implications for gender inequity and the perpetuation of objectification of women are discussed. 相似文献
854.
Kees-Jan Kan 《Intelligence》2011,39(5):292
On the one hand, the factors Gf and Gc in the Cattell-Horn-Carroll (CHC) model of intelligence are hypothesized to represent individual differences in unique psychological or biological capacities. On the other hand, they are interpreted as representing the theoretical variables fluid and crystallized intelligence in investment theory. With respect to Gc, this leads to a theoretical conflict because in investment theory crystallized intelligence is not a capacity but purely a statistical entity. We contend that if CHC factor Gc represents a capacity, it cannot represent crystallized intelligence, and if Gc represents crystallized intelligence, it does not represent a capacity. In addition, from our discussion of Gc, we conclude that in investment theory the factors Gf and g represent one and the same capacity. In support of our theoretical conclusions, we implemented the CHC model in a confirmatory factor analysis of a HCA (Human Cognitive Abilities project) data set. As expected, Gf and g were statistically indistinguishable. Gc was effectively absent, because it was statistically equivalent to verbal comprehension. Factors Gc and g could be removed from the model without any reduction in model fit. We argue that in the CHC taxonomy the factors Gc and g are redundant as explanatory variables. 相似文献
855.
856.
双因子模型假设测验考察一个一般因子和多个组因子,符合很多教育和心理测验的因素结构。“维度缩减”方法将参数估计中多维积分计算化简为多个迭代二维积分,是双因子模型的重要特征。本文针对考察多级评分项目的计算机化自适应测验,首先推导双因子等级反应模型下Fisher信息量的计算,然后推导“维度缩减”方法在项目选择方法中的应用,最后在低、中、高双因子模式题库中比较D-优化方法、后验加权Fisher信息D优化方法(PDO)、后验加权Kullback-Leibler方法(PKL)、连续熵(CEM)和互信息(MI)方法在能力估计的相关、均方根误差、绝对值偏差和欧氏距离的表现。模拟研究表明:(1)双因子模式越强,即一般因子和组因子在项目上的区分度的差异越小,一般因子估计精度降低,组因子估计精度增加,整体能力的估计精度提高;(2)相同实验条件下,连续熵方法的测量精度最高,PKL方法的能力估计精度最低,其它方法的测量精度没有显著差异。 相似文献
857.
随着心理与教育测量研究的发展和科技的进步,计算机化(大规模)测验逐渐受到人们的关注。为探究在计算机化多维测验中如何利用作答时间数据来辅助评估多维潜在能力,以及为我国义务教育阶段教育质量监测提供数据分析方法上的理论支持。本研究以2012年和2015年国际学生能力评估(PISA)计算机化数学测验数据为例,提出了一种可同时利用作答时间和作答精度数据的联合作答与时间的多维Rasch模型。根据新模型对PISA数据的分析结果,表明引入作答时间数据,不仅有助于提高模型参数的估计精度,还有助于数据分析者利用被试的作答时间信息来做进一步的决策和干预(e.g., 对异常作答行为或预备知识的诊断)。 相似文献
858.
John T. Mitchell Nathan A. Kimbrel Natalie E. Hundt Amanda R. Cobb Rosemery O. Nelson-Gray Christopher M. Lootens 《欧洲人格杂志》2007,21(7):869-887
Reinforcement Sensitivity Theory (RST) and the Five-Factor Model (FFM) are two prominent personality accounts that have emerged from different backgrounds. Although the two accounts are applied to similar research topics, there is limited empirical work examining the correspondence between them. The current study explored the relationship between RST-based personality traits and the FFM domains and facets in an undergraduate sample (n = 668). Regression analyses indicated that Sensitivity to Punishment (SP) was positively associated with Neuroticism and Agreeableness, and negatively associated with Extraversion, Openness, and Conscientiousness. In contrast, Sensitivity to Reward (SR) was positively associated with Extraversion and Neuroticism, and negatively associated with Agreeableness and Conscientiousness. Exploratory analyses at the facet level specified the relationship between SP, SR, and each domain. A factor analysis was also conducted to explore the higher-order factor structure of RST and the FFM domains. Three factors emerged, which we labelled SP, Stability-Impulsivity, and Sensation Seeking. Taken together, these findings suggest that there is substantial overlap between these two accounts of personality. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
859.
行政人员的道德责任不是一个内涵固定不变的范畴 ,随着行政模式的变迁 ,行政的方向和方式都在发生变化 ,对行政人员的道德责任也会有相应的要求 ,专制行政、精英行政和公共行政对行政人员的道德责任要求甚至是大相径庭的。就其核心道德责任而言 ,专制行政要求忠诚 ,精英行政追求效率 ,公共行政呼唤公正。在这个基础上 ,我们才能谈论中国公共行政中行政人员的道德责任及其实现的问题。 相似文献
860.
A human stigmergy model of product development through a series of incremental novelties and imitations is obtained by observing the isomorphism between solution trees generated by groups of humans participating in online games like Foldit, self-organizing topics in online learning systems, product evolution through a combination of innovation and imitation in the cell phone industry, and social networks formed over the past 40 years in creation of the Boston biotech commons. The model incorporates two very simple rules: (1) preferential attachment, and (2) the combination of existing product designs into a single design. A computer model used to simulate the model produces product evolution networks isomorphic to observed solution trees and product evolution trees. Additionally, industries with a high degree of novelty produce a product evolution network with scale-free and betweenness centrality structure. 相似文献