脑的感知觉无意识加工及其研究进展

该文从无意识加工与认知、脑结构,神经网络的关系等三个层面,阐述了近年来认知神经科学在无意识研究方面的进展。主要就无意识与意识的相互转化、无意识加工与认知层次、脑结构之间的关联性、突触的联结方式等问题进行了讨论,并对认知神经科学如何研究无意识与意识问题提出展望,     

The Genesis of Mind and Spirit

Spiritual life is made possible by the evolution of a human neuropsychology that requires social interdependence for its development. Extensive neuroplasticity requires experiential shaping throughout life. The evolution of frontal cortex hypertrophy suggests that much of this shaping is produced by a socially constructed virtual reality, extending beyond immediate experience. Prefrontal colonization makes possible the social scaffolding of neuroregulation, including the emotional attachments necessary for moral life. Cognitive independence from immediate environments enables symbioses with external memory systems, producing novel forms of socially constituted experience and making possible the transformative effect of religious systems upon individual biologies and psychologies.     

骨源性因子ucOCN在运动抗抑郁中的作用机制

羧化不全骨钙素(ucOCN)是骨中成骨细胞分泌的特异性蛋白,因其在调控神经发育、神经可塑性等中的重要角色而受到神经科学领域关注。"骨-脑"串联"对话"是骨内分泌-神经介导的应答系统,ucOCN透过血脑屏障后介导单胺类神经递质、神经内分泌、神经免疫、神经再生及基因表达等机制,进而作用于海马CA3区、扣带回等脑区功能发挥来调节抑郁发生及改善。而ucOCN作为骨源性力学刺激敏感基因,运动上调其表达后进入血液循环,通过介导5-HT/GABA分泌、HPA轴功能、炎症反应、神经营养因子(BDNF等)表达或信号途径(如GSK3β/β-catenin、TLR4/miR-223/NLRP3等)激活等来实现"骨串联脑",发挥运动抗抑郁作用。通过对骨源性因子ucOCN介导脑区功能变化从而实现运动抗抑郁的作用机制进行探讨、梳理,一方面有助于更深入了解骨内分泌功能,另一方面为抑郁发生、改善和运动抗抑郁研究提供新的理论基础和研究思路。     

CONSCIOUSNESS AND THE MACHINE

Abstract. We consider only the relationship of consciousness to physical reality, whether physical reality is interpreted as the brain, artificial intelligence, or the universe as a whole. The difficulties with starting the analysis with physical reality on the one hand and with consciousness on the other are delineated. We consider how one may derive from the other. Concepts of universal or pure consciousness versus local or ego consciousness are explored with the possibility that consciousness may be physically creative. We examine whether artificial intelligence can possess consciousness as an extension of the interrelationship between consciousness and the brain or material reality.     

GOD IS GREAT, GOD IS GOOD: JAMES ASHBROOK'S CONTRIBUTION TO NEUROETHICAL THEOLOGY

Abstract. James Ashbrook's work has not only clarified issues in brain and belief, it has offered intriguing suggestions for ethics. The relevance of neurotheology to ethics is evident if we assume that ethics entails, in part, concerns about character, responsibility, and the art of living.     

Evidence of the origin of specific spontaneous head turns during intertrial intervals

Direction and the frequency of spontaneous head movements during the ITIs following forward and backward paired trials were compared to an acquisition of a conditioned orienting (alpha) response directed to the side of the tone source. The head movements were analyzed from video recordings using classification of head turns to preferred and to nonpreferred directions. The results showed a significant increase in the alpha responses during the forward paired conditioning to the preferred direction and rapid extinction during the subsequent backward conditioning sessions. Spontaneous head movements during the ITIs increased to the same preferred direction as the conditioned alpha responses. The results of this experiment suggest that the response initially elicited by the CS can later appear as “spontaneous,” instrumental behavior, the form and the nature of which is determined by the characteristics of the conditioned alpha response developing as a result of classical conditioning.     

The Patriarchal Mind as the Ignored Root of Interpersonal and Social Pathologies

The article begins with an integrative theory of neurosis and with the notion of the “patriarchal mind,” which I conceive as the psycho-social foundation of what we call “civilisation” and proceed to characterize as a despotic and repressive activity of the father on the mother and on the child in the family, and also of an analogous relation between the intellect on the emotional and on the instinctual sub-selves in the individual mind. Next, I propose that patriarchy entails four interrelated problems: (1) violent authority; (2) the eclipse of caring; (3) the repression of instinct; and (4) the invalidation of intuition; and point out that since these are evident in our well-recognized social problems, these may be traced down to the “patriarchal complex” that in turn defines patriarchal society. Finally, I develop the idea that not only is the patriarchal mind is embodied in each of the known interpersonal or character pathologies, but that each of these pathologies contributes to the systemic and cultural presence of the patriarchal mind. The corollary of this analysis is that the healing of both our interpersonal and social pathologies will depend on the healing of the patriarchal mind, which is conceivably possible to bring about through a specially designed education oriented to the balanced development of “three-brained beings,” in whom a balance has been achieved between the intellectual, emotional, and instinctive sub-selves that constitute our mind.     

Adapting Cognitive Processing Therapy to Treat Co-Occurring Posttraumatic Stress Disorder and Mild Traumatic Brain Injury: A Case Study

This case study aims to provide evidence for the effectiveness of adapting a particular manualized cognitive behavioral therapy intervention to treat co-occurring posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI). This study presents the treatment of a woman who experienced co-occurring mTBI and PTSD following a motor vehicle accident, a dual diagnosis that was established through a flexible assessment approach involving interviews as well as standardized psychological, neuropsychological, and neurobehavioral testing. Treatment planning led to a-priori adaptation of Cognitive Processing Therapy (CPT) to treat both her PTSD symptoms and the sequelae associated with her mTBI. The therapist maintained fidelity to the manualized structure and content of CPT protocol, adapting portions of the treatment to add specific emphasis on issues of identity confusion and role loss in service of addressing these common functional impairments that can accompany mTBI. Discussion focuses on application of CPT for future treatment of comorbid PTSD and TBI amidst complicating factors, including role losses and medical and safety issues. This case study is especially relevant due to the prevalence of co-occurring PTSD and TBI across a variety of populations.