从体外受精技术获诺贝尔奖谈从事转化医学研究

转化医学是促进基础研究向临床应用的转化,同时根据临床实际提出应用基础研究课题。从2010年获诺贝尔生理学或医学奖体外受精技术的发展,探讨了转化医学研究的内容和实现转化医学研究的途径,以便更好地促进临床医学研究。     

Gender Differences in Problem Drinking and Depression: Different “Vulnerabilities?”

This study examines the relationship between stressors and resources and the functioning of a sample of 515 men and women who had a drinking problem. At a one-year follow-up, both women and men had improved on three functioning measures: alcohol consumption, days intoxicated, and depression. There were no gender differences at Time 2 on alcohol consumption, but men had more days intoxicated and women had more symptoms of depression. The impact of stressors and resources varied by life domain, functioning criterion, and gender. Although the predictors varied, the amount of variance in depression accounted for was the same for women and men. The most striking gender difference was the stronger impact of friendships for women on all aspects of functioning. This study provides support for reconsideration of the stress vulnerability of women and men.     

不同情绪状态下自动表达抑制对情绪及表情知觉敏感性的影响

以103名大学生为对象,在正性、负性两种情绪状态下,用句子整理任务引发被试抑制情绪或表达情绪两种情绪调节方式,采用信号检测论测得正、负性表情的表情知觉敏感性。结果表明：（1）表情知觉敏感性存在情绪一致性效应,在负性情绪状态下,人们对负性表情更敏感,差异显著（p=0.002）;在正性情绪状态下,人们对正性表情更敏感,虽然只是边缘显著（p=0.700）。（2）自动抑制情绪会降低人们的情绪体验,并且会影响表情知觉敏感性的情绪一致性效应。在自动抑制启动的状态下,人们对正、负性表情都不太敏感。     

中小学生考试成败归因的研究

从小三、初二、高二随机选择有效被试４１０名,探讨了中小学生对考试结果的归因、期望和情感反应的特点。结果发现：（１）中小学生对考试成败原因有不同的认知,年级差异显著,性别差异不显著。（２）失败后的期望显著地高于成功情境,且极显著地认为失败的结果能改变。（３）成功后学生主要产生了感激、自豪与欣慰,失败后主要产生了内疚;成功后的情感反应更强烈。     

Alcohol use and stress in women: The role of prior vs. anticipated stressors

The present study investigated stress-related drinking in women. Alcohol consumption in response to stress and in anticipation of a stressor was examined to evaluate women's use of alcohol to cope with stress. Subjects were assigned to one of four conditions in a 2 × 2 factorial design in which order of alcohol consumption and stress task as well as stress level was manipulated. Findings indicate that subjects did not consume alcohol to cope with the effects of either a prior stressor or an upcoming stressor. These results suggest the need for further refinement of notions concerning women's use of alcohol to cope with stress.     

Antisocial behavior reduces the association between subdimensions of ADHD symptoms and alcohol use in a large population‐based sample of adolescents

The aim of this study was to investigate possible effects of antisocial behavior on reducing the association between subdimensions of ADHD symptoms (inattention, hyperactivity and impulsivity) and alcohol use. Boys and girls were analyzed separately using a population‐based Swedish adolescent sample. A randomly selected cross‐sectional survey was performed in secondary and upper secondary schools in Västmanland County during 2010. Participants were a population of 2,439 15–16 year‐olds and 1,425 17–18 year‐olds (1,947 girls and 1,917 boys). Psychosocial adversity, antisocial behaviors, symptoms of ADHD and alcohol use were assessed by questionnaires. Except for girls' inattention, subdimensions of ADHD symptoms were not associated with alcohol use when variance due to antisocial behavior was accounted for. Among boys, instead of an indirect effect of antisocial behavior on the association between impulsivity and alcohol use, a moderating effect was found. Among girls, the inattention component of ADHD was independently associated with alcohol use even when adjusted for antisocial behavior. The reduced associations between symptoms of hyperactivity, impulsivity, and alcohol use for boys and girls after adjusting for antisocial behavior suggest a considerable overlap between hyperactivity, impulsivity, and antisocial behavior. The direct pathway between inattention and alcohol use among girls suggests that girls with inattention symptoms are at risk of alcohol use regardless of antisocial behavior. Special attention should be given to these girls. Accounting for antisocial behavior reduced the relation between subdimensions of ADHD symptoms and alcohol use, and antisocial behaviors should therefore be screened for when symptoms of ADHD are present.     

Manipulation and force as sexual coercion tactics: conceptual and empirical differences

This study examines the relationship between perpetrator characteristics, situational characteristics, and type of sexual coercion tactics used to obtain sexual contact (including sexual intercourse) with an unwilling partner. Men who used manipulation or force were compared to each other and to men who engaged in only consensual sex. Participants were college men drawn from the first wave of a 5-year longitudinal study. Stepwise discriminant function analyses, univariate analyses of variance (ANOVA), and chi(2) analyses tested group differences. As predicted, men who used force reported more childhood sexual abuse, witnessed more domestic violence, were more accepting of male violence, and were less likely to endorse love as a motive for sex than men in both the manipulation and consent groups. Men in the force group were also more likely to have had a casual relationship with the woman, and to be drinking and also intoxicated during the coercive incident than men in the manipulation group. Hypothesized differences between men who used force and manipulation regarding parental physical punishment, traditional gender role attitudes, delinquency, hedonistic and dominance motives for sex, prior sexual contact, and the length of the relationship were not supported. The results suggest that types of tactic used in sexual assaults can be distinguished on the basis of person and situational variables and that knowledge of these differences can facilitate future research, as well as rape deterrent and intervention programs.     

大脑前扣带回皮层与执行功能

回顾了近期有关大脑前扣带回皮层（ACC）参与执行功能的研究资料。结果显示,ACC可以对正在进行的目标定向行为实施在线监控,在出现反应冲突或错误时提供信号,以便能及时调整与分配注意资源,因此可能是一个行为规划与执行的高级调控结构。这两年来的新发现提示,ACC的执行监控作用可能是基于动机与奖赏期待做出的对“意志行动”的整合性控制,并可能具有对行动结果的情绪评价意义。     

Stimulus selection with duration as a relevant cue

To date, research has not explicitly examined how duration competes with other stimulus dimensions for control over responding. The present study investigated some familiar selective mechanisms of stimulus control over key pecking in pigeons, with duration and line tilt as discriminative stimuli in successive discrimination procedures. Specifically, pigeon's key pecking was reinforced with food or extinguished following compound stimuli comprising one of two line orientation stimuli presented for one of two different durations. Traditional experimental designs explored stimulus additivity, overshadowing, blocking, and learned irrelevance. Although stimulus additivity was observed, control by duration was masked by line tilt in extinction testing that followed facilitated acquisition with redundant, relevant cues. In addition, although prior training with duration relevant partially blocked subsequent acquisition of control by line tilt when both stimulus dimensions were relevant, there was a tendency for control by duration to decrease with continued compound training. It was suggested that the greater time required to distinguish duration on a trial—compared to more commonly studied stimulus dimensions, which can be distinguished almost immediately—puts duration at a competitive disadvantage in situations where other relevant dimensions are also available.     

压力性生活事件对青少年烟酒使用的影响：基本心理需要和应对方式的链式中介作用

采用压力性生活事件量表、基本心理需要量表、特质应对方式问卷和烟酒使用问卷对867名青少年进行调查,考察了基本心理需要和积极应对方式、消极应对方式在压力性生活事件与烟酒使用关系中的链式中介效应。结果表明：（1）基本心理需要是压力性生活事件与青少年烟酒使用之间的中介变量;（2）积极应对方式、消极应对方式是基本心理需要与青少年烟酒使用之间的中介变量。因此,基本心理需要和积极应对方式、消极应对方式在压力性生活事件与青少年烟酒使用之间起链式中介作用。研究结论对青少年烟酒使用的预防和干预具有重要价值。