非传统理念指导下的传统技术导致应用医学重大课题的突破--关于2005年诺贝尔生理学或医学奖

发现幽门螺杆菌(Helicobacter pylori,以下简称Hp)导致慢性胃炎和消化性溃疡,是沃伦和马歇尔获得2005年诺贝尔医学奖的原因.他们在1982年得出的这一假说,违反了关于这一类慢性病传统的发病机制理念.可能因为这一理念的反传统性,其假说被世界同行基本接受大概经历了20年时间.值得强调的是,对HP的观察、分离、培养、鉴定和人体试验,以及它与疾病相关的诊断、治疗、临床流行病学等研究,应用的都是传统的医学技术.从而表明,即使到了20世纪80年代,传统技术仍能导致诺贝尔奖级科研成果的出现.     

Antecedents of mentoring support: a meta-analysis of individual,relational, and structural or organizational factors

The value of mentoring is growing substantially as organizations take a renewed interest in employee development to better survive in the dynamic and competitive market today. In the wake of this renewed interest, this meta-analysis was conducted to quantitatively review the multi-level antecedents (e.g., individual, relational, and structural/organizational) of different kinds of mentoring support (e.g., career, psychosocial, role modeling) in organizational settings and to revisit the theoretical underpinnings of each antecedent. Results indicated some key antecedents of mentoring support at individual (e.g., protégé's proactivity, protégé's learning goal orientation, mentor's transformational leadership), relational (e.g., affect based trust, perceived similarity), and structural/organizational levels (e.g., organizational support for mentoring, supervisory mentoring). Recommendations for future research and organizational practice of mentoring are presented.     

The relationship between body weight and perceived weight-related employment discrimination: The role of sex and race

This study provides unique empirical evidence regarding a growing concern internationally: weight discrimination in the workplace. Using survey data from a national sample of 2838 American adults, it responds to Puhl and Brownell’s [Puhl, R., & Brownell, K. D. (2001). Bias, discrimination, and obesity. Obesity Research, 9, 788-805] call for additional research investigating the prevalence of discriminatory experience among overweight employees, and to their more specific call for research that takes sex and race into account when examining weight discrimination. The results indicate that women are over 16 times more likely than men to perceive employment related discrimination and identify weight as the basis for their discriminatory experience. In addition, overweight respondents were 12 times more likely than normal weight respondents to report weight-related employment discrimination, obese 37 times more likely, and severely obese more than 100 times more likely. The implications of the study’s findings for organizations, policy makers, overweight employees, and career counselors are discussed, and future research directions suggested.     

Recurrent binge eating with and without the "undue influence of weight or shape on self-evaluation": implications for the diagnosis of binge eating disorder

Levels of eating disorder psychopathology, impairment in psycho-social functioning and use of health services were compared among probable cases of binge eating disorder (BED) with and without extreme weight or shape concerns ("undue influence of weight or shape on self-evaluation") recruited from a large community sample of women. Data for obese non-binge eaters (n=457), also recruited from the community sample, and for a clinical sample of eating disorder patients (n=128), recruited separately, were included for comparative purposes. BED cases who reported extreme weight or shape concerns (n=51, 46.4%) had significantly higher levels of eating disorder psychopathology and functional impairment than those who did not report such concerns (n=59), after controlling for between-group differences in age and body weight. In addition, BED cases who reported extreme weight or shape concerns were more likely to have sought treatment for an eating or weight problem than those who did not. Whereas levels of eating disorder psychopathology and functional impairment were markedly elevated among BED cases with extreme weight or shape concerns, BED cases who did not report extreme weight or shape concerns resembled obese non-binge eaters in most respects. The findings support the inclusion of an undue influence of weight or shape on self-evaluation as a diagnostic criterion for BED. In the absence of this influence, eating disorders that otherwise resemble BED do not appear to be "clinically significant".     

Offspring Effects of Prenatal Alcohol Exposure from Birth to 25 Years: The Seattle Prospective Longitudinal Study

Before alcohol was generally known to cause birth defects, NIAAA in 1974 began funding a population-based Seattle study on alcohol use and pregnancy outcome. Women receiving prenatal care by mid-pregnancy were recruited (N = 1,529) and interviewed at home. Approximately 500 offspring exposed to a range of alcohol levels were examined on 11 occasions between day 1 and 25 years. Neuropsychological and neurobehavioral performance measures are correlated with prenatal alcohol dose, without substantial confounding by socio-demographic or rearing conditions, smoking, nutrition, or other drugs. Deficits in attention, arithmetic skill, spatial-visual memory, and IQ, as well as increased alcohol problems and psychiatric disorders are among offspring outcomes correlated at several ages with maternal drinking during and before pregnancy recognition. Findings are not confined to women who believed they had alcohol problems. Not all exposed offspring appear affected.     

INCREASING SEAT BELT USE ON A COLLEGE CAMPUS: AN EVALUATION OF TWO PROMPTING PROCEDURES

Seat belt use is an important factor in the prevention of automobile accidents involving injuries and fatalities. The current study used a multielement design to compare the “Click It or Ticket” and “Please Buckle Up—I Care” procedures. Results indicate that the Click It or Ticket prompt resulted in a 20‐percentage‐point increase in seat belt use, and Please Buckle Up—I Care resulted in a 14‐percentage‐point increase.     

流动人口的饮酒行为及其影响因素分析

选择从农村流入到北京打工的18-30岁的年轻流动人口共2201人参加问卷调查,要求被试自我报告他们的饮酒行为、流动时间、流动城市数量以及抑郁和满意度状况,并根据他们所从事的13种职业的性质将之归类为“低危”和“高危”两类,以考察环境和个体因素与流动人口饮酒行为的关系。结果表明:(1)在过去1个月中,27%的流动人口曾醉过酒,男性流动人口的醉酒率是女性的2倍(35%vs.16%)。但流动人口的饮酒行为不存在显著的年龄、教育水平和婚姻状况的差异;(2)相关分析表明,高危职业流动人口的饮酒行为显著地高于低危职业的流动人口。同时,与没有醉过酒的流动人口相比,曾醉酒者的抑郁情绪更多,生活和工作满意度更低;(3)Amos结果表明,环境和个体因素相互作用影响流动人口的饮酒行为。流动性通过满意度以及抑郁情绪间接地影响流动人口的饮酒行为,职业性质对饮酒行为产生直接的影响,同时,职业性质又通过生活满意度和抑郁情绪间接地作用于流动人口的饮酒行为。     

小鼠新颖寻求特质对酒精的运动激活效应的影响

新颖寻求(或感觉寻求)特质与许多成瘾药物的易感性密切相关。例如, 高、低新颖寻求动物对可卡因、苯丙胺和吗啡等成瘾药物的奖赏、运动激活、强化效应的反应存在差异。长期饮用酒精也容易成瘾, 但尚未发现关于新颖寻求特质影响酒精成瘾的报道。本实验采用药物成瘾研究中常用的自发活动模型, 考察了高、低新颖寻求动物在酒精急性处理、慢性处理和激发过程中的行为表现。实验过程中首先采用两种新颖寻求模型, 即新颖环境中自发活动模型和新颖客体偏爱模型, 将昆明小鼠分别区分为高、低自发活动组和高、低新颖客体偏爱组, 连续10天给予酒精(2g/kg/d, i.p.)或等量盐水处理, 戒断2天后所有小鼠接受酒精(2g/kg)激发。实验结果表明, 新颖环境低自发活动小鼠比新颖环境高自发活动小鼠对酒精急性、慢性处理导致的运动激活效应更敏感; 在酒精激发期前者的自发活动水平也高于后者。本实验结果说明新颖环境中自发活动特质影响动物对酒精导致的运动激活效应的反应。     

关系-表征复杂性模型的检验

目前有关问题难度的观点多是不全面的,在综合前人研究的基础上提出了关系-表征复杂性模型。在该模型里,区分了问题难度和问题解决难度两个概念,二者的本质分别是关系复杂性和表征复杂性;关系复杂性包括水平复杂性和等级复杂性,表征复杂性相应地包括表征广度和表征深度。以172名小学高年级学生为被试,以长方形面积问题方面的三种测验收集的数据对该模型的内部和外部效度进行了检验,结果表明它能够有效解释问题（解决）难度,区分优、中、差三类学生所能达到的表征复杂性。这说明该模型有理论价值