Observed behaviors during clinical interviews predict improvement in depression

A considerable percentage of depressed patients do not respond to antidepressive treatment. Early indicators of prognosis are needed. The aims of this study are to examine (a) whether the interpersonal behavior of patients and psychiatrist, as assessed by means of direct observation of behavior during a baseline clinical interview, might have predictive value with respect to therapeutic outcome and (b) which predictive potency measures of psychomotor activation, as assessed by less refined methods, such as global clinical judgment, might have. In the analysis used, speech-pause behavior was taken as the basic structure of the interaction. The relations of other behaviors such as looking and hand and head movement with this structure were determined. Evidence is presented that in a group of 31 depressives, improvement after a period of 10 weeks was related to observed behaviors during a baseline interview. The behaviors of the patients are interpreted as relational or nonrelational. The relational behaviors (i.e., looking yesnodding, gesturing) occur less in patients who will improve, whereas the nonrelational behaviors (i.e., intensive body touching, head movements) occur more in these patients. The nonrelational behaviors are presumed to be indicative of the state of arousal. The predictive potency of these variables could not be explained by their relationship with the baseline severity of depression, which in itself also predicted improvement. Moreover, global clinical assessment of psychomotor activation (i.e., retardation and agitation) could not be related to outcome.     

Anticipation across modalities in children and adults: Relating anticipatory alpha rhythm lateralization,reaction time,and executive function

The development of the ability to anticipate—as manifested by preparatory actions and neural activation related to the expectation of an upcoming stimulus—may play a key role in the ontogeny of cognitive skills more broadly. This preregistered study examined anticipatory brain potentials and behavioral responses (reaction time; RT) to anticipated target stimuli in relation to individual differences in the ability to use goals to direct action (as indexed by measures of executive function; EF). A cross-sectional investigation was conducted in 40 adults (aged 18–25 years) and 40 children (aged 6–8 years) to examine the association of changes in the amplitude of modality-specific alpha-range rhythms in the electroencephalogram (EEG) during anticipation of lateralized visual, tactile, or auditory stimuli with inter- and intraindividual variation in RT and EF. Children and adults exhibited contralateral anticipatory reductions in the mu rhythm and the visual alpha rhythm for tactile and visual anticipation, respectively, indicating modality and spatially specific attention allocation. Variability in within-subject anticipatory alpha lateralization (the difference between contralateral and ipsilateral alpha power) was related to single-trial RT. This relation was more prominent in adults than in children, and was not apparent for auditory stimuli. Multilevel models indicated that interindividual differences in anticipatory mu rhythm lateralization contributed to the significant association with variability in EF, but this was not the case for visual or auditory alpha rhythms. Exploratory microstate analyses were undertaken to cluster global field power (GFP) into a distribution-free temporal analysis examining developmental differences across samples and in relation to RT and EF. Anticipation is suggested as a developmental bridge construct connecting neuroscience, behavior, and cognition, with anticipatory EEG oscillations being discussed as quantifiable and potentially malleable indicators of stimulus prediction.     

Episodic memory effects of gamma frequency precuneus transcranial magnetic stimulation in Alzheimer's disease: A randomized multiple baseline study

Episodic memory decline is the prominent neuropsychological feature of typical Alzheimer's Disease (AD), for which current treatments have a limited clinical response. Recently, gamma entrainment therapy has been used as a non-invasive treatment in AD, providing evidence that it may have the potential to alleviate brain pathology and improve cognitive function in AD patients. At the same time, the precuneus (PC) has been recognized as a key area involved in AD related memory deficits and as a key node of the Default Mode Network. This study aimed to investigate the effectiveness of a 40 Hz Transcranial Magnetic Stimulation (TMS) intervention, delivered bilaterally to the precuneus for 10 days, in improving the patients' episodic memory performance. Secondary outcome variables investigated included general cognitive function, semantic and spatial memory, as well as attention and executive function. A concurrent multiple baseline design across five cases was employed. Four patients completed the study. Visual analysis combined with effect size indices were used to evaluate changes across phases. An increase in the average level of immediate recalled words was observed in three out of four patients. Effect size indices indicated significant improvement of attention skills in two patients. No treatment effect was observed for semantic and visual memory, or for executive function. An immediate treatment effect was observed in all patients' general cognitive function as assessed with the Alzheimer's Disease Assessment Scale (mean reduction of 5 points), which was maintained and improved further three months post-treatment. The neuropsychological evaluations indicated improved performance three months post-treatment in immediate and delayed recall, attention, phonological verbal fluency, anxiety, and neuropsychiatric symptoms. This study provides preliminary evidence for the efficacy of a novel non-pharmacological treatment using gamma-band TMS in addressing cognitive dysfunction in AD.     

DIE MARXISMUS – DEBATTE IM “SILBERNEN ZEITALTER”

Im Anfang des 20.Jahrhunderts unterzog eine Reihe von jungen, später berühmt gewordenen Philosophen den Marxismus einer tiefen Kritik. Ihnen ist es gelungen, wichtige Defekte der revolutionären Doktrinen aufzudecken und ihre verhängnivsollen Konsequenzen vorwegzunehmen. Diese Kritik ist auch für die gegenwärtige geistig-politische Situation aktuell.     

Apocalyptic Argument and the Anticipation of Catastrophe: the Prediction of Risk and the Risks of Prediction

This essay proposes to extend the model of apocalyptic argument developedin my recent book Arguing the Apocalypse (OLeary, 1994) beyond the study ofreligious discourse, by applying this model to the debate over awell-publicized earthquake prediction that caused a widespread panic in theAmerican midwest in December, 1990. The first section of the essay willsummarize the essential elements of apocalyptic argument as I have earlierdefined them; the second section will apply the model to the case of the NewMadrid, Missouri, earthquake prediction, in order to demonstrate thatcertain patterns of reasoning characteristic of religious apocalyptic arepresent in the discourse over an anticipated local disaster. My ultimatepurpose is to show that predictions of global and local catastrophe mayserve as extreme cases that will illuminate the dynamics of predictiveargument in general. Thus my argument will seek to undercut Daniel Bellsdistinction between prophecy and prediction (Bell, 1973) by establishingthat these discourses share identifiable formal and substantivecharacteristics, and depend for their rhetorical effect on anxiety, hope,far, and excitement as modes of temporal anticipation.     

Antecedents of information-processing skills in infants: Habituation, novelty responsiveness, and cross-modal transfer

Three skills which characterize cognitive functioning in human infants in the middle of the first year of life—habituation, novelty responsiveness, and cross-modal transfer—predict mental ability in later childhood. Antecedents of each skill at 5 months postnatal were examined in a short-term prospective longitudinal study of infant ability and maternal intelligence and interaction style. Infant perceptuocognitive performance at 2 months, maternal intelligence, and maternal responsiveness at 5 months relate to the expression of the three infant cognitive skills, but in different ways. Variation in infant information-processing abilities can be explained by specific child and maternal factors that are evident soon after birth.     

Correlation and prediction in ordinal test theory

Based on the test theory model for ordinal measurements proposed by Schulman and Haden, the present paper considers correlations between tests, attenuation, regressions involving true and observed scores, and prediction of test reliability.The population correlation between tests is shown to be related to the expected sample correlation for samples of sizen ₁ andn ₂. Errors of estimation, measurement and prediction are found to be similar to their counterparts in interval test theory, while attenuation is identical to its counterpart. The bias in estimating population reliability from sample data is compared for Kendall's tau and Spearman's rho.The author wishes to thank the referees for their helpful comments on an earlier draft of this paper, and in particular, for the suggested alternative methods of establishing some of the presented results.     

风险偏好预测中的性别差异和框架效应

11 8名大学生被试在得益和损失两种任务框架下对自己、其他男性和女性的风险偏好进行了预测。结果发现 ,被试在损失框架下对各类对象风险偏好的预测均高于得益框架 ,且都高估了男性的风险偏好 ,低估了女性的风险偏好。在损失框架下 ,女性被试对各类对象的风险偏好预测高于男性的预测。研究认为 ,性别原型知识、任务框架和即时情绪共同影响被试的风险偏好预测。     

青少年结果预期与评价的ERP研究

大脑不断地对环境事件产生预期并将这些预期与实际结果进行比较, 通过对反馈刺激的结果评价以优化后续行为。采用抽奖式赌博任务范式, 操纵得奖的确定性程度, 利用事件相关电位技术(ERP), 研究青少年结果预期与评价的认知和神经电生理过程, 以成人作为对照组进行比较分析。研究结果表明：(1)在反映自动、快速结果评价的FRN上, 无论在高确定性还是在低确定性条件下, 青少年与成人均未表现出显著性差异; (2)组别与确定性程度在P300波幅上表现交互作用显著, 简单效应分析表明, 在高确定性条件下, 青少年组输、赢的P300波幅表现出差异; 而成人组输、赢的P300波幅无显著性差异。青少年对反馈刺激自动的快速结果评价能力已接近成人水平, 而对反馈刺激功能意义评价的控制加工能力还未发展成熟。     

初级军官心理选拔的预测性

目的：通过建立院校学员胜任特征及初级军官评价模型,探讨初级军官心理选拔检测系统的预测性。方法：某军校340名男性本科学员入校时完成初级军官心理选拔检测,毕业前进行院校胜任特征评价,对162名学员毕业后1~5年进行部队工作表现追踪评价。结果：中国MBTI-G人格类型测验对院校学员管理能力、影响力、约束力、口头表达、军人气质、人际关系等有较好的预测性,预测符合率72.13%;中国军人明尼苏达个性调查表6项精神障碍维度对情绪稳定性有较好的预测,预测符合率71.90%;院校学员一般能力倾向测验对学业成绩、文字表达、口头表达、人际关系和决策能力等胜任特征也有一定的预测性,预测符合率66.70%;三项测验院校胜任特征总预测符合率达81.70%,部队胜任特征总预测符合率76~87%。结论：为我军初级军官心理选拔提供了实用工具,为提高心理选拔预测准确性提供了科学依据