Combination Effects of Forced Mild Exercise and GABAB Receptor Agonist on Spatial Learning,Memory, and Motor Activity in Striatum Lesion Rats

Basal ganglia (BG) lesions cause impairments of different mammalian’s movement and cognition behaviors. Motor circuit impairment has a dominant role in the movement disorders. An inhibitory factor in BG is GABA neurotransmitter, which is released from striatum. Lesions in GABAergic neurons could trigger movement and cognition disorders. Previous evidence showed that GABA_B receptor agonist (Baclofen) administration in human improves movement disorders and exercise can improve neurodegenerative and cognitive decline; however, the effects of both Baclofen and mild forced treadmill exercise on movement disorders are not well known. The main objective of this study is to investigate the combined effects of mild forced treadmill exercise and microinjection of Baclofen in the internal Globus Pallidus on striatum lesion-induced impairments of spatial learning and motor activity. We used Morris water maze and open filed tests for studying spatial learning, and motor activity, respectively. Results showed that mild exercise and Baclofen microinjection could not lonely affect the spatial learning, and motor activity impairments while the combination of them could alleviate spatial learning, and motor activity impairments in striatum-lesion animals. Our results suggest that striatum lesion-induced memory and motor activity impairments can improve with combination interaction of GABA_B receptor agonist and exercise training.     

Linking family dysfunction to suicidal ideation: Mediating roles of self-views and world-views

Research on suicide has documented various factors predicting suicidal ideation. The present study focused on the pathways emanating from one of the external, environmental forces (i.e. family dysfunction) through internal responses (beliefs about oneself and about the world), to suicidal ideation among Hong Kong Chinese. Using structural equation modelling, we tested the mediating roles of depressive self-views (including stress perception, depressive cognition and negative self-esteem) as well as two dimensions of social axioms (social cynicism and negative reward for application). Multi-group analysis showed that the mediation model was invariant across both males and females. Being socialized into a problematic family of origin affected multiple aspects of one's assessments of both oneself and one's world which, in turn, lead to greater suicidal ideation. Our findings provide important implications for assessing suicidal risk and guiding interventions in clinical treatment.     

Sexual Side Effects of Antidepressant Medications: An Informed Consent Accountability Gap

Sexual side effects of antidepressant medications are far more common than initially reported, and their scope, quality, and duration remain poorly captured in the literature. Antidepressant treatment emergent sexual dysfunctions may decrease clients’ quality of life, complicate psychotherapy, and damage the treatment alliance. Potential damage to the treatment alliance is greatest when clients have not been adequately informed of risks related to sexual side effects. It had previously been assumed that sexual side effects always resolve shortly after medications are discontinued. Emerging evidence, however, suggests that in some individuals, sexual dysfunction side effects may persist indefinitely. The authors argue that all psychologists should be well-informed about sexual side effects risks of antidepressant medications, should routinely conduct a pre-medication baseline assessment of sexual functioning, and take an active role in the informed consent process.

The psychological treatment of memory impairment: A review of empirical studies

Memory impairment is a frequent effect of many different forms of brain dysfunction. Memory impairment is also a frequent focus of treatment interventions, and there have been many different treatment methods suggested. The suggested methods include direct retraining, the use of spared skills in compensating for the impairment (alternate functional systems), and the use of behavioral strategies to circumvent the manifest memory dysfunction (behavioral prosthetics). Unfortunately, there are very few studies comparing the various suggested treatment methods. The present paper evaluates the empirical evidence related to the treatment of memory dysfunction and suggests directions for future investigations. Although the evidence is not conclusive, it appears that some forms of treatment may be helpful in remediating certain types of memory impairment. An approach likely to be productive would include some consideration of the impaired neurological and psychological mechanisms responsible for the manifest memory deficit as well as a consideration of the etiology of the injury thought to be causally related to the memory deficit. As yet, there have been no rigorous empirical evaluations of these considerations.     

非失语脑中风患者的神经心理障碍与一年疗效和康复预测的关系

本文以７９例脑中风患者为对象,研究结果如下：１．自编ＡＤＬ,再测信度和结构效度合格。２．一年前后ＡＤＬ、ＤＮＦ及疗效与同期测定的插棍测验、瑞文测验、小棍测验、临摹图形、说同类词及抑郁（一年后）有显著相关。３．初发病时这些指标及图形拼凑测验与一年后ＡＤＬ、ＤＮＦ及疗效也有显著相关。４．ＤＮＦ１和ＡＤＬ１对疗效有明显预测作用,可解释变量的３５％（ＡＤＬ２）、３７％（疗效）和４１％（ＤＮＦ２）。单独心理变量可解释变量的２７％（ＡＤＬ２）、３３％（ＤＮＦ２）和２１％（疗效）。     

Sleep apnea syndrome: Symptomatology,associated features,and neurocognitive correlates

This article reviews the essential features, types, prevalence, pathophysiology, and neuropsychological correlates associated with the sleep apnea syndrome. Persons who experience the intermittent hypoxia and fragmented sleep characteristic of the sleep apnea syndrome tend to exhibit moderate symptoms of diffuse cognitive dysfunction as well as multiple emotional and psychosocial sequela. It is concluded that more research is required in order to elucidate the relationship between the hypoxic parameters and neurocognitive deficits seen in the sleep apnea syndrome, and that neuropsychological assessment might represent a means whereby the effectiveness of various treatments for sleep apnea may be evaluated.     

发展性阅读障碍的理论及眼动研究

关于发展性阅读障碍,国外研究者,基于认知和生物因素,先后提出了语音缺陷论、小脑缺陷论、一般性大细胞功能障碍论等对发展性阅读障碍进行解释,并考察了患者的眼动特征,提出了有效的诊治方法。目前,汉语发展性阅读障碍研究主要局限在语音和正字法领域,也涉及局部脑区的功能缺陷,但还未从多角度测查其成因,如眼动。这里,在理论梳理的基础上,系统探讨了发展性阅读障碍者的眼动特征,如注视时间、注视次数、眼跳、回视等,及视觉加工的眼动机制     

Three Native American Women Speak About the Significance of Ceremony

In greater numbers, Native health care givers are caring for Native American people. This article explores the significance of ceremony from the perspective of three Native women elders. Choctaw shop proprietor Phyllis Hogan explains how she was able to accept her aging when at 40 years old she performed a menstruation ceremony. Lorena Lomatuwayma is head of the sacred Mazua (Women's Society) in Hoteville, Arizona. She reflects upon the spiritual significance of ceremony in a Hopi's life. Medicine Woman Mary K. Boone is a well-known Navajo herbalist and healer. She describes her role as elder and advisor in her culture and speaks about the Navajo view of death.