Effects of the Novel Acetylcholinesterase InhibitorN-Octyl-1,2,3,4-tetrahydro-9-aminoacridine on Locomotor Activity and Avoidance Learning in Mice

The acetylcholinesterase reversible inhibitorN-octyl-1,2,3,4-tetrahydro-9-aminoacridine (THA-C8) is a new synthesized derivative of tacrine (THA) characterized by an alkyl chain in the molecular structure which ameliorates the penetrability of the compound into the central nervous system. THA-C8 (0.1–5 mg/kg) significantly reduced spontaneous locomotor activity in CD1 mice at a dose of 3 mg/kg. Moreover, THA-C8 (0.2–2 mg/kg) significantly improved shuttle-box avoidance acquisition at doses (0.25, 0.3, 1 mg/kg) not affecting locomotion and that are much lower than the doses reported to be effective for THA in animal models. From the data reported it seems that the new compound could be interesting for therapeutic purposes.     

Coping and emotional distress in a sample of Swedish unemployed.

The study investigated the associations between coping and symptoms of emotional distress within a sample of 166 unemployed men and women (mean age 40 +/- 10 years, range 22 to 63 years, 52% males). All variables were measured with a questionnaire comprising sociodemographic background, length of unemployment, financial strain, coping style ("Ways of Coping Checklist"), and emotional distress (Hopkins Symptom Check List-25). Emotional distress was positively related to financial strain and more common among younger subjects, divorced subjects and those with foreign background, but less frequent among subjects who had been unemployed for more than three years. After controlling for age, gender, education, foreign background, length of unemployment and financial strain, hierarchical regression analyses showed that emotion-focused coping, i.e. self-blame and wishful thinking, was positively related to emotional distress. Problem-focused coping and cognitive restructuring were negatively associated with emotional distress. Younger subjects and divorced subjects made frequent use of both emotion-focused and problem-focused coping. Female subject and subjects with mandatory school made frequent use of emotion focused coping, if exposed to high financial strain. Problem-focused coping was less frequent among subjects with a low education coupled with low financial strain. Cognitive restructuring was less common among subjects who had been unemployed for more than three years. Younger subjects who were also divorced made less use of both problem-focused coping and cognitive restructuring. The results confirm that coping style has importance for the mental health of the unemployed, and indicate a differential use of coping strategies among subjects with different sociodemographic backgrounds and different levels of financial strain.     

Disgusting clusters: trypophobia as an overgeneralised disease avoidance response

Individuals with trypophobia have an aversion towards clusters of roughly circular shapes, such as those on a sponge or the bubbles on a cup of coffee. It is unclear why the condition exists, given the harmless nature of typical eliciting stimuli. We suggest that aversion to clusters is an evolutionarily prepared response towards a class of stimuli that resemble cues to the presence of parasites and infectious disease. Trypophobia may be an exaggerated and overgeneralised version of this normally adaptive response. Consistent with this explanation, individuals with trypophobia, as well as comparison individuals, reported aversion towards disease-relevant cluster stimuli, but only the trypophobic group reported aversion towards objectively harmless cluster stimuli that had no relevance to disease. For both groups the level of aversion reported was predicted uniquely by a measure of disgust sensitivity. Scaled emotion ratings and open-ended responses revealed that the aversive response was predominantly based on the disease avoidance emotion, disgust. Many open-ended responses also described skin sensations (e.g. skin itching or skin crawling). These findings support the proposal that individuals with trypophobia primarily perceive cluster stimuli as cues to ectoparasites and skin-transmitted pathogens.     

Be aware of the rifle but do not forget the stench: differential effects of fear and disgust on lexical processing and memory

The aim of this study was to investigate the role of discrete emotions in lexical processing and memory, focusing on disgust and fear. We compared neutral words to disgust-related words and fear-related words in three experiments. In Experiments 1 and 2, participants performed a lexical decision task (LDT), and in Experiment 3 an affective categorisation task. These tasks were followed by an unexpected memory task. The results of the LDT experiments showed slower reaction times for both types of negative words with respect to neutral words, plus a higher percentage of errors, this being more consistent for fear-related words (Experiments 1 and 2) than for disgust-related words (Experiment 2). Furthermore, only disgusting words exhibited a higher recall accuracy than neutral words in the memory task. Moreover, the advantage in memory for disgusting words disappeared when participants carried out an affective categorisation task during encoding (Experiment 3), suggesting that the superiority in memory for disgusting words observed in Experiments 1 and 2 could be due to greater elaborative processing. Taken together, these findings point to the relevance of discrete emotions in explaining the effects of the emotional content on lexical processing and memory.     

Testing emotional memories: does negative emotional significance influence the benefit received from testing?

A large body of research shows that emotionally significant stimuli are better stored in memory. One question that has received much less attention is how emotional memories are influenced by factors that influence memories after the initial encoding of stimuli. Intriguingly, several recent studies suggest that post-encoding factors do not differ in their effects on emotional and neutral memories. However, to date, only detrimental factors have been addressed. In the present study, we examined whether emotionally negative memories are differentially influenced by a well-known beneficial factor: the testing of memories. We employed a standard cued recall testing-effect paradigm where participants studied cue-target pairs for negative and neutral target pictures. In a subsequent post-encoding phase, one third of the cue-target pairs were tested and one third restudied; the remaining third served as control pairs. After one week, memory for all cue-target pairs was tested. While replicating both the testing effect and the emotional enhancement effect, no differences between negative and neutral memories in the benefits received from testing and restudying were observed. Thus, it seems to be true that post-encoding factors do not influence emotional memories in any other way than neutral memories, even when they are beneficial.     

The role of pupil size in communication. Is there room for learning?

The eyes are extremely important for communication. The muscles around the eyes express emotional states and the size of the pupil signals whether a person is aroused and alert or bored and fatigued. Pupil size is an overlooked social signal, yet is readily picked up by observers. Observers mirror their own pupil sizes in response, which can influence social impressions. In a landmark study by Hess [1975. The role of pupil size in communication. Scientific American, 233(5), 110–119] it was shown that individuals with large pupils are perceived more positively than individuals with small pupils. In that behavioral study, participants were asked to draw pupils in line drawings of faces with empty irises and they drew large pupils in the happy face, and small ones in the angry face. The current study tested 579 participants (aged 4–80 years old) and extended this work by showing that this association between large (small) pupils and a positive (negative) impression develops over age and is absent in children. Several explanations for how individuals through interactions with close others learn that large pupils mean care, interest and attention and small pupils the opposite, are discussed. To conclude, this study shows that pupil size and emotion perception are intertwined but that their relationship develops over age.     

Subtypes of severe psychological distress among US Air Force remote warriors: A latent class analysis

US Air Force remote warrior personnel include a range of military personnel composed of remotely piloted aircraft aircrew, intelligence operators, and cyber warfare operators. Job duties in these professions entail long work hours, rotating shifts, and regular engagement in combat operations. Although research has identified a number of factors correlated with elevated burnout and emotional distress in this population, little is known about the unique needs of discrete subgroups of distressed personnel. In a sample of 7,550 US Air Force remote warriors, results of latent class analysis yielded four distinct classes. Three of the four reported moderately elevated burnout and job dissatisfaction but differed with respect to demographics and development career stage. The fourth group reported significantly higher levels of emotional distress, burnout, job dissatisfaction, and problems in living. This latter group was comparable to the mid-career group with respect to demographics, although this group had much lower levels of responsibility and indicators of career advancement. Results suggest that, among remote warrior personnel, there are several subtypes of elevated emotional distress. Prevention and intervention strategies that are matched to each subtype may yield better occupational and mental health outcomes than universal, “one size fits all” strategies.     

The nature and consequences of topic avoidance in Chinese and Taiwanese close relationships

Two studies examined topic avoidance in Chinese and Taiwanese opposite‐sex friendships and romantic relationships. Five areas of topic avoidance emerged through analytic induction and cluster analysis: negative appraisal, relational issues, sexual issues, politics, and personal experience. Partner protection, negative relational impact, and self inefficacy emerged as the most common reasons for avoidance. Results revealed that friends, relative to romantic partners, engaged in higher levels of topic avoidance. Taiwanese participants, moreover, avoided discussing politics to a greater extent than did mainland Chinese participants. Lacking closeness was the main reason behind avoidance of political discussion. Topic avoidance was also linked to relationship quality, as relational satisfaction negatively predicted relational issue avoidance and topic avoidance breadth (i.e. the number of topics regularly avoided in the relationship). The authors explain these and other findings based on Chinese cultural codes and historically‐embedded concepts that shape interpersonal interaction.     

Energy psychology and psychotherapy: A study of the use of energy psychology in psychotherapy practice

Aim: The aim of the study was to increase understanding of how energy psychology informs and affects counselling/psychotherapy practice. By undertaking phenomenological interviews with experienced clinicians, the aim was to enrich and expand on the scientific approaches to energy psychology research. Method: This research is based on in‐depth semi‐structured interviews using interpretative phenomenological analysis (IPA). Five experienced psychotherapists who are also practitioners of energy psychology were interviewed. Findings: Four main themes emerged from the analysis: energy psychology as a potent intervention that facilitates shifts in emotions, cognitions, behaviours and physiology; the safety of energy psychology techniques; the role of the therapeutic relationship when using energy psychology techniques; and the challenges of integrating energy psychology into the work context, highlighting the need for more complex, systemic models to understand how people experience distress and how change is facilitated. Conclusion: Overall, participants in this study found energy psychology to be a valuable supplement to counselling and psychotherapy. The implications for current practice are discussed.