Resistance and outcome expectations in cognitive‐behavioural therapy for generalised anxiety disorder

Greater client resistance has been consistently found to be negatively associated with outcome in psychotherapy. However, the pathways through which resistance impacts such outcomes are underexplored. Given that client outcome expectation (OE) has been identified as an important common factor in psychotherapy, the goals of the present study were to examine: (a) the impact of resistance on subsequent client and therapist OE (COE & TOE, respectively); and (b) whether COE and/or TOE mediate the relationship between resistance and outcome. These relationships were tested among 44 clients with severe generalised anxiety disorder treated with cognitive‐behavioural therapy in the context of a randomised controlled trial (Westra, Constantino, & Antony, 2016). Resistance was measured at a mid‐treatment session, and COE and TOE were assessed at baseline and immediately after the resistance session. Treatment outcome was measured via client‐rated worry severity at post‐treatment. As predicted, higher resistance was associated with lower subsequent COE and TOE; B = ?.73, p < .001 and B = ?.46, p < .001, respectively. In turn, lower post‐resistance COE predicted higher post‐treatment worry (B = ?.5, p < .001), indicating mediation. In contrast, TOE did not mediate the relationship between resistance and outcome (B = ?.02, p = .876). These results suggest that resistance can be demoralising to both clients and therapists. However, only lower client morale may be detrimental to therapy outcome. This study contributes to understanding outcome pathways through two common therapy processes.     

情绪的相容性对创造性思维的影响

为探讨具身内隐情绪和外显情绪之间的相容性和不相容性对创造性思维的影响,实验采用情绪视频启动范式诱发被试的积极情绪或消极情绪,同时采用面部表情操纵技术诱导其具身积极情绪或具身消极情绪,然后要求被试完成创造性思维测验中的替代使用任务（AUT）与顿悟字谜测验。结果发现：在积极情绪下,情绪相容组的AUT流畅性得分显著高于情绪不相容组;而在消极情绪下,情绪相容组的AUT原创性得分与顿悟字谜得分显著高于情绪不相容组;灵活性在两种情绪条件下的差异均不显著。结果表明,面部表情和外显情绪的相容性有利于创造性思维的表现,积极情绪和消极情绪下的情绪相容性分别影响着创造性思维的不同成分。     

Network change point detection in resting-state functional connectivity dynamics of mild cognitive impairment patients

Background/Objective: This study aims to characterize the differences on the short-term temporal network dynamics of the undirected and weighted whole-brain functional connectivity between healthy aging individuals and people with mild cognitive impairment (MCI). The Network Change Point Detection algorithm was applied to identify the significant change points in the resting-state fMRI register, and we analyzed the fluctuations in the topological properties of the sub-networks between significant change points. Method: Ten MCI patients matched by gender and age in 1:1 ratio to healthy controls screened during patient recruitment. A neuropsychological evaluation was done to both groups as well as functional magnetic images were obtained with a Philips 3.0T. All the images were preprocessed and statistically analyzed through dynamic point estimation tools. Results: No statistically significant differences were found between groups in the number of significant change points in the functional connectivity networks. However, an interaction effect of age and state was detected on the intra-participant variability of the network strength. Conclusions: The progression of states was associated to higher variability in the patient's group. Additionally, higher performance in the prospective and retrospective memory scale was associated with higher median network strength.     

Development of rules and strategies: balancing the old and the new

The experiments described in the lead articles replicate findings from previous studies of development of knowledge about balance scales, add several new findings, and raise four key questions: (a) How can rule use best be assessed? (b) How can we reconcile systematic use of rules with variable use of strategies? (c) When do children begin to use rules? and (d) How do children generate new rules? In this Reflection, we summarize current understanding of development of knowledge about balance scales and consider each of the four questions.     

Developmental and content effects in reasoning with causal conditionals

Two predictions derived from Markovits and Barrouillet's (2001) developmental model of conditional reasoning were tested in a study in which 72 twelve-year-olds, 80 fifteen-year-olds, and 104 adults received a paper-and-pencil test of conditional reasoning with causal premises ("if cause P then effect Q"). First, we predicted that conditional premises would induce more correct uncertainty responses to the Affirmation of the consequent and Denial of the antecedent forms when the antecedent term is weakly associated to the consequent than when the two are strongly associated and that this effect would decrease with age. Second, uncertainty responding to the Denial of the antecedent form ("P is not true") should be easier when the formulation of the minor premise invites retrieval of alternate antecedents ("if something other than P is true"). The results were consistent with the hypotheses and indicate the importance of retrieval processes in understanding developmental patterns in conditional reasoning with familiar premises.     

关于胚胎干细胞研究的一场伦理之争

关于“人兔细胞融合”的伦理之争,主要围绕“人兔细胞融合”实验是否违背伦理,要不要经过知情同意,以及科学技术与伦理道德的关系等问题而进行。这场讨论是正常的,健康的,有益的,倘能加以认真总结,将有助于推进学术争鸣。     

Longing for Life Extension: Science Fiction and Late Life

Rejuvenescence has long been a topic of legend and medicine. As the body became the property of medical science, speculative fiction asked how fantastic experiments with bodies would affect the life course. In science fiction, medical breakthroughs promise or threaten to forestall or even reverse the decline from midlife through old age to senility and decrepitude. Responding to debates over evolution, eugenics, and scientific experimentation with human and animal subjects, rejuvenescence novels such as Bruce Sterling's Holy Fire (1996) ask readers whether they desire long life or heightened quality of life; the consolations of age or the hungers of youth; short-lived intensity or perpetual ennui.     

Conflicts of interest in science in Armenia

The author describes problems facing Armenia in reorganization of the structure of science in the post-socialist era with the aim of utilizing limited state resources more efficiently by reducing the number of separate scientific institutes, concentrating on essential core subjects required by the nation and encouraging all other projects to compete in the international arena for grant sponsorship. An earlier version of this paper was presented at an International Conference on “Conflict of Interest and its Significance in Science and Medicine” held in Warsaw, Poland on 5–6 April, 2002.     

The continuing need for disinterested research

For scientific knowledge to be trustworthy, it needs to be dissociated from material interests. Disinterested research also performs other important non-instrumental roles. In particular, academic science has traditionally provided society with reliable, imaginative public knowledge and independent, self-critical expertise. But this type of science is not compatible with the practice of instrumental research, which is typically proprietary, prosaic, pragmatic and partisan. With ever-increasing dependence on commercial or state funding, all modes of knowledge production are merging into a new, ‘post-academic’ research culture which is dominated by utilitarian goals. Growing concern about conflicts of interest is thus a symptom of deep-seated malaise in science and medicine. An expanded version of this paper was presented at an International Conference on “Conflict of Interest and its Significance in Science and Medicine” held in Warsaw, Poland on 5–6 April, 2002.     

中小学生认知能力发展水平测验的研究

以皮亚杰的认知发展理论为基础,采用皮亚杰及其学生研究认知发展时的任务为测验题目,编制成测量中小学生认知能力发展水平的测验.通过对2240名中小学生施测,结果表明本测验不仅具有很好的信度和效度,而且也具有适中的难度.然后以一所中学特长班学生为被试,通过对他们进行测量,并将测验结果与同年级普通班学生的认知成绩进行比较,结果存在很明显的差异.最后对中小学生认知能力发展水平测量问题进行了探讨.