Neuropsychological outcome of GPi pallidotomy and GPi or STN deep brain stimulation in Parkinson's disease

This paper highlights the neuropsychological sequelae of posteroventral pallidotomy (PVP) and deep brain stimulation (DBS) of the subthalamic nucleus (STN) and the internal segment of the globus pallidus (GPi) at 3/6 months postoperatively. Results are based on our extensive experience with PVP and our preliminary observations with DBS. Patients with borderline cognitive or psychiatric functioning risk postoperative decompensation. Nonlateralizing attentional and hemisphere-specific impairments of frontostriatal cognitive functions followed unilateral PVP. "Frontal" behavioral dyscontrol was observed in approximately 25% of patients. Three cases of staged bilateral PVP suggest that premorbid factors may predict outcome, although lesion size and location are also critical. Older patients are at risk for significant cognitive and behavioral decline after bilateral STN DBS, while GPi DBS may be safer.     

Leader–follower risk orientation incongruence,intellectual stimulation,and creativity: A configurational approach

Prior work suggests that follower and leader risk orientation is positively associated with follower creativity. We suggest that this view is oversimplified and propose that follower creativity can be stimulated when leader and follower have diverging risk orientations. We, therefore, apply a configurational approach to creativity, evaluating varying combinations of leader and follower risk orientation on follower creativity. Across two field studies, we demonstrate that (a) follower creativity increases as leaders’ and followers’ risk orientations become more discrepant (i.e., incongruent); (b) follower creativity is higher when leader–follower dyads are congruent at moderate levels of risk orientation compared to congruence at the extremes (i.e., low and high levels); (c) follower‐experienced intellectual stimulation mediates the relationship between leader–follower risk orientation incongruence and congruence and follower creativity; and (d) that leader authority openness moderates the indirect effect of leader–follower risk orientation incongruence on creativity via follower‐experienced intellectual stimulation. Theoretical and practical implications specific to creativity and leader–follower relationships are discussed.     

Responses to visual,tactile and visual–tactile forward collision warnings while gaze on and off the road

The objective of the current driving simulator study (N = 20) was to assess brake reaction time (BRT) and subjective experiences of visual (V), tactile (T), and visual–tactile (VT) collision warnings when the drivers’ visual orientation was manipulated between four locations (i.e., road and three different mirror locations). V warning was a blinking light in a windscreen, T warning was implemented by a vibrating accelerator pedal, and VT warning was their synchronous combination. The results showed that all the warning stimuli were detected in 100% accuracy in all visual orientations, but T and VT warnings produced significantly faster BRTs when compared to V warning. It was found that BRT to V warning was the slowest while observing the furthermost side mirror. However, BRTs following T and VT warnings remained unaffected by the visual orientations. Both the objective BRT measurements and subjective evaluations indicated a superiority of T and VT warnings against a sole V warning, not only in general terms, but also separately for different visual orientations.     

经颅直流电刺激在注意缺陷多动障碍治疗中的应用

经颅直流电刺激(tDCS)治疗注意缺陷多动障碍(ADHD)主要是选取患者的背外侧前额叶(DLPFC)作为刺激区域, 通过调节其皮层兴奋性, 从而缓解其ADHD的症状和改善其受损的认知功能。针对tDCS在ADHD治疗研究中的问题, 未来可从有效性、确定最佳刺激参数、个体差异、不同亚型及与其他疗法联合使用等五个方面来进一步研究。     

足月胎儿对声音刺激反应的探讨

通过观察声音刺激引起胎儿产生的胎动和胎心率反应,初步探讨声音刺激能否引起胎儿的感觉和相应的反射机制。选择正常足月孕妇94例,分别接受95、100、105、110、115分贝的声音刺激,观察胎儿的胎动和胎心率反应。95分贝声音能引起胎心率轻度下降且不引起胎动,而声强在100分贝以上的声音刺激能引起胎心率加速并伴有胎动,提示95分贝声音可以引起胎儿的定向反射,和胎儿的选择性的注意有关;而100~115分贝的声音能引起胎儿的防卫反应。婴儿与生俱来的无条件反射在胎儿期就已存在。     

An evaluation of the effects of response interruption redirection and matched stimulation on vocal stereotypy

Stereotypy is one of the core diagnostic features of autism spectrum disorder and warrants behavioral intervention when it negatively impacts the person's life. The aim of this study was to evaluate the effectiveness of noncontingent matched stimulation (NCR‐M) compared with response interruption redirection (RIRD) on reducing levels of vocal stereotypy in the natural environment. Interventions were compared using an alternating treatments design followed by generalization and maintenance phases, which utilized lay people as instructors. Results showed that both RIRD and NCR‐M resulted in a reduction in vocal stereotypy for three out of four participants within an educational setting. An increase in appropriate vocalizations was found for two out of four participants for both interventions. These results suggest that both NCR‐M and RIRD were effective in reducing levels of vocal stereotypy, yet their effects on appropriate communication remain undetermined. Social validity scores were obtained following the study, which demonstrated that both interventions were met with approval across a variety of measures.     

Differences in numeric,verbal, and spatial reasoning between engineering and literature students through a neurocognitive lens

This study used electroencephalography to investigate the brain activations of college students of various disciplines when they responded to questions in numeric, verbal, and spatial reasoning tasks. In total, 15 engineering students and 15 literature students were recruited in this experiment and were asked to respond to 12 intelligence test questions. The results were as follows: (i) the participants’ brain activations increased in the frontoparietal network during the numeric reasoning task, and the spectral power in the right anterior temporal cortex was generally higher in the literature students than in the engineering students. (ii) Activations of the language network were observed during the verbal reasoning task, and the spectral power in the right-biased posterior frontal cortex was generally higher in the literature students than in the engineering students; by contrast, the spectral power in the left lateral frontal cortex was generally higher in the engineering students than in the literature students. (iii) The participants’ brain activations increased in the spatial processing network during the spatial reasoning task, and the spectral power in the right posterior temporal cortex was generally higher in the literature students than in the engineering students.     

Interactions between perinatal and neonatal associative learning defined by contiguous olfactory and tactile stimulation

Tactile stimulation of the neonate, as performed by the mother during and after delivery, has been described as an effective unconditioned stimulus during early ontogeny (Leon, 1987; Ronca & Alberts, 1994). The present experiments examined the interaction between perinatal and neonatal learning determined by the explicit association between alcohol odor and vigorous body stimulation of the perinatal organism. In Experiment 1, rat fetuses were exposed to either alcohol or saline 10 min prior to cesarean delivery. The alcohol administration procedure here employed was sufficient to provide sensory contamination of the amniotic fluid but avoid fetal alcohol intoxication. Pups in the two prenatal treatments later experienced the smell of alcohol, tactile stimulation, or both stimuli explicitly paired or unpaired. Other postnatal groups were composed of pups that had no explicit experience with either experimental stimulus. Pups subjected to alcohol odor in utero displayed more overall motor activity in response to that odor than saline controls. The increased motor responses were further potentiated in pups that experienced additional postnatal alcohol odor paired with tactile stimulation. In Experiment 2, pups were exposed to alcohol in the amniotic fluid 10 or 30 min prior to birth. As previously demonstrated the memory acquired in utero appears highly dependent upon contingency between exposure to this particular scent and delivery procedures. Pups in both prenatal treatment groups were then exposed to alcohol odor paired or unpaired with tactile stimulation. Some control animals received no further experience with either stimuli. Those pups exposed to alcohol odor paired with tactile stimulation both pre- and postnatally later showed maximum motor activity elicited by the odor of alcohol. The results support the notion of fetal associative learning comprising alcohol's chemosensory cues and behaviorally activating stimuli. Furthermore, the conditioned response under analysis is potentiated whenever neonates are reexposed to contingent presentations of the elements that defined the original associative memory.     

Assessment of Biopsychosocial Risk Factors for Medical Treatment: A Collaborative Approach

There is a growing body of evidence that psychosocial variables have a significant ability to predict the outcome of medical treatment procedures, especially when the procedure is performed to reduce pain. The study described in this paper serves as an illustration of the valuable role psychologists can play in dealing with the challenges of biopsychosocial assessment of patients who are candidates for medical treatments, especially elective, invasive procedures. Based on a convergent model of risk factors that can potentially influence outcomes from spinal surgery and spinal cord stimulation, exclusionary and cautionary risk factors were identified, and the BHI 2 and BBHI 2 tests were used to assess them. An estimate of the prevalence of these risk factors was calculated using data obtained from 1,254 patient and community subjects gathered from 106 sites in 36 US states. Standardized Cautionary Risk and Exclusionary Risk scores demonstrated a test-retest reliability of .85 to .91. Evidence of validity of these scores was also provided based on subjective and objective criteria, using multiple groups of patients and community subjects. Recommendations are made regarding how biopsychosocial assessments could be used in collaborative settings for presurgical candidates to identify risks that could compromise a patient’s ability to benefit from other medical treatments as well. Once identified, appropriate interventions could ameliorate these risks, or lead to the consideration of other treatments that are more likely to be effective. Methods of refining this approach for specific clinical applications are also discussed.     

内隐学习研究40年

内隐学习至今已有40年的研究历史。在这期间,内隐学习的研究对象、研究方法和本质特征都得到了深入和扩展。主要体现在：内隐学习的研究材料从同时性刺激走向序时性刺激;内隐学习的研究方法从主观阈限的测量逐渐扩展到客观阈限测量,又再回到主观阈限测量之上;内隐学习的本质特征从抽象到具体,再落脚于熟悉性