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81.
阿尔茨海默病(AD)是常见的中枢神经系统变性疾病,是痴呆最常见的病因,发病率高.病理特征为老年斑及神经元纤维缠结.AD的确诊有赖病理学,临床诊断极其耗时.由于尚无准确的早期诊断方法,常使AD患者错过早期治疗的时机,这成为制约有效防控AD的瓶颈问题.因此寻找高敏感性、特异性、无创性的生物学标志物对AD的早期诊断至关重要.本文仅将目前较为广泛研究的生物学标志物及其研究现状作一概述.分别对脑脊液、血液、尿液及唾液中的AD标志物作逐一介绍. 相似文献
82.
《Journal of Religious & Theological Information》2013,12(1):85-109
ABSTRACT This review article provides a detailed comparison of two major patristic databases, the Patrologia Latina and the CETEDOC Library of Christian Latin Texts from a user's perspective. 相似文献
83.
The authors collected information from caregivers, trained observers, and parents to investigate quality elements in child-care programs designed for young children in center-based settings. Participants were 75 parents of children aged 15 to 36 months and their caregivers from 13 child-care centers in a southeastern state. Observers collected indicators of program quality and process and structural quality indicators, including adult-child ratio, group size, use of planned activities, use of child-designated space, housekeeping activities, and caregiver-child interactions. Participants responded to questions regarding their child-rearing beliefs, social support networks, perceived stress levels, and demographic characteristics. The best predictors of higher quality care and sensitive caregiver-child interaction in centers were specialized caregiver training, higher adult-child ratios, use of planned activities, and less perceived stress by caregivers. Implications of these findings are discussed. 相似文献
84.
Children's development is assumed to be closely related to their attachment security and their personality. The authors’ aim was to examine the joint contribution of attachment security and personality traits to children's adjustment by examining diverse children's outcomes (emotional symptoms, social functioning, and behavioral problems) and using various perspectives (children, parents, and teachers). The sample comprised 247 8–12-year-old children from low socioeconomic status neighborhoods. Personality and attachment contribute to the different domains of adjustment. In cases of moderation, attachment security moderates the implications of personality traits on children's adjustment. The findings highlight the contribution of positive personality tendencies in playing down the difficulties of insecurely attached children. 相似文献
85.
Sandra Leanne Bosacki 《The Journal of genetic psychology》2013,174(2):170-191
The author investigated the longitudinal relations between theory of mind (ToM) understanding and perceptions of self and social conversations in 17 school-aged children (12 girls, 5 boys, age 8–12 years). ToM was assessed at Time 1 (T1; M age = 8 years 5 months, SD = 8.7 months, and perceptions of self and conversational experiences assessed two years later at Time 2 (T2; M age = 10 years 4 months, SD = 7.9 months. Most importantly, longitudinal findings showed that children who scored relatively high on ToM at T1 reported relatively lower perceptions of self-worth and higher number of mental states verbs in their perceptions of peer and family conversations at T2. Significant negative longitudinal associations were found between children's number of siblings and their perceptions of self-worth (T1) and number of cognitive terms in their perceptions of peer and family conversations (T2). Frequency analysis suggested that girls’ perceptions of conversations referred to more social and psychological aspects of self and relationships, whereas boys focused mainly on physical activities. Most children were more likely to prefer listening to talking during social conversations. The majority of children reported feelings of mixed or ambiguous emotions during experiences of silence. Implications for socioemotional and cognitive development in early adolescents are discussed. 相似文献
86.
Michael J. Wavering Linda J. Kelsey Bruce Perry 《The Journal of genetic psychology》2013,174(3):279-288
This study explored the relationship between illegitimate birth and cognitive development among 513 boys on probation. Prior research has shown that being part of a single-parent household leads to diminished verbal capacities and often puts a child in greater danger of abuse and neglect. Frequent abuse is thought to lead to the enhancement of visual and spatial skills relative to verbal skills through a process of “frozen watchfulness”. I hypothesized that illegitimate boys from one-parent homes would have greater verbal-performance discrepancy scores than would boys from other combinations of birth status and family structure. These boys had the lowest verbal IQ and highest performance IQ scores and, hence, the largest discrepancy. These boys also suffered the highest degree of abuse and neglect of all four birth status/family structure combinations studied. 相似文献
87.
We assessed the relation between the empathic responsiveness of young adults and the relative frequency and intensity of distressful events they experienced as children. Undergraduate subjects (N = 111; 56 men and 55 women) were led to believe that they were participating in two separate studies. In the first study, students completed the Distress Experiences in Childhood questionnaire, a filler task, and a slightly abbreviated version of the Mehrabian and Epstein (1972) empathy measure. In the second study, students watched an emotion-laden videotape of a patient (actually an actress) in a therapy session and subsequently completed an emotional-response questionnaire adapted from Batson, O'Quin, Fultz, Vanderplas, and Isen (1983). Students who rated their distressful childhood experiences as highly distressing scored higher on both measures of empathy than did students who rated their experiences as relatively less distressing. In contrast, the number of distressful childhood experiences reported was generally unrelated to empathy scores. 相似文献
88.
Lida Anagnostaki Michael J. Wright Alison J. Bourchier-Sutton 《The Journal of genetic psychology》2013,174(4):279-299
The authors explored whether young children can distinguish potential secrets from nonsecrets by their content, as can older children, adolescents, and adults. Ninety children, 4, 5, and 6 years old, rated the secrecy of items from an adult-validated list of personal information about an age- and gender-appropriate puppet. Two factors of the children's data corresponded to the adult categories of nonsecrets and secrets, and a third factor corresponded to surprises. All ages rated surprises as significantly more secret than nonsecret items; however, the surprise items contained linguistic cues to secrecy. A tendency to rate nonsecrets as secret decreased with age, but only the 6-year-olds rated secrets other than surprises as significantly more secret than nonsecrets. Thus, children acquire the implicit rules defining secret content from a somewhat later age than that reported for the cognitive or behavioral capacities for secrecy. 相似文献
89.
90.