Neuropsychological assessment could distinguish among different clinical phenotypes of progressive supranuclear palsy: A Machine Learning approach

Progressive supranuclear palsy (PSP) is a rare, rapidly progressive neurodegenerative disease. Richardson’s syndrome (PSP-RS) and predominant parkinsonism (PSP-P) are characterized by wide range of cognitive and behavioural disturbances, but these variants show similar cognitive pattern of alterations, leading difficult differential diagnosis. For this reason, we explored with an Artificial Intelligence approach, whether cognitive impairment could differentiate the phenotypes. Forty Parkinson's disease (PD) patients, 25 PSP-P, 40 PSP-RS, and 34 controls were enrolled following the consensus criteria diagnosis. Participants were evaluated with neuropsychological battery for cognitive domains. Random Forest models were used for exploring the discriminant power of the cognitive tests in distinguishing among the four groups. The classifiers for distinguishing diseases from controls reached high accuracies (86% for PD, 95% for PSP-P, 99% for PSP-RS). Regarding the differential diagnosis, PD was discriminated from PSP-P with 91% (important variables: HAMA, MMSE, JLO, RAVLT_I, BDI-II) and from PSP-RS with 92% (important variables: COWAT, JLO, FAB). PSP-P was distinguished from PSP-RS with 84% (important variables: JLO, WCFST, RAVLT_I, Digit span_F). This study revealed that PSP-P, PSP-RS and PD had peculiar cognitive deficits compared with healthy subjects, from which they were discriminated with optimal accuracies. Moreover, high accuracies were reached also in differential diagnosis. Most importantly, Machine Learning resulted to be useful to the clinical neuropsychologist in choosing the most appropriate neuropsychological tests for the cognitive evaluation of PSP patients.     

Predicting physical activity intention and behaviour using achievement goal theory: A person-centred analysis

The purpose of the current study was to identify the 2 × 2 achievement goals profiles at the intraindividual level using a latent profile analyses (LPA) approach while controlling for the nesting of students within classroom. Additional analyses involving the direct inclusion of predictors and outcomes to the final latent profile solution were also used to examine the relationships between the latent profiles and perceived motivational climate, intention to be physically active and physical activity participation. A sample of 1810 school children aged 14–19 years drawn from 79 classes in 13 Singaporean schools took part in the study. Using the latent profile analysis, four distinct motivational profiles could be identified. The results from multinomial logistic regressions showed that profile membership was significantly predicted by perceptions of mastery and performance climate. Finally, the results showed that the four profiles differed significantly in terms of intention to be physically active and physical activity participation.     

Team adaptability and task cohesion as resources to the non-linear dynamics of workload and sickness absenteeism in firefighter teams

ABSTRACT

The current study builds on the non-linear Dynamic Systems (NDS) perspective to test the assumption that change in sickness absenteeism is non-linear, and that such change is due to workload, team adaptability and task cohesion. Participants were 37 firefighter teams (n = 250 individuals) from a main European capital city. The research hypotheses were tested using SPSS and the “cusp” package, in the statistical software R. The results suggest that change in sickness absenteeism behaviours over time is non-linear, with the cusp catastrophe model predicting such behaviours better than the linear and logistic models. In our model, task cohesion functions as an asymmetry factor (i.e., the independent variable that determines the strength and discrepancy between the two stable states of the dependent variable) leading to a linear change in sickness absenteeism. Interestingly, both workload and team adaptability function as bifurcation (i.e., the independent variable that determines the change between the two stable states of the order parameter) and asymmetry factors leading to non-linear and linear change in sickness absenteeism over time. This study contributes to the growing evidence that incorporating the NDS perspective enables a better understanding of action teams, namely those working in extreme environments.     

The temporal dimension in the understanding of maternal sensitivity in caregiver-infant interactions: The ‘Early Mother-Child Interaction Coding System’

Caregiver-child interaction is known to play a central role in children’s socioemotional development, yet the diversity of measures commonly used to evaluate it call into question the nature of the construct being assessed. Contingency within caregiver-child interactions has been identified as a key dyadic process that requires taking a temporal perspective to evaluating interactions. The Early Mother-Child Interaction Coding System is a psychometrically sound measure that sequentially code the flow of interactive and non-interactive behaviours within a caregiver-infant system. Its use of the framework of nonlinear dynamical systems (NDS) expands our understanding of contingent caregiver-infant dyadic behaviour.     

Estimating Age-Based Developmental Trajectories Using Latent Change Score Models Based on Measurement Occasion

Abstract

Accelerated longitudinal designs (ALDs) are designs in which participants from different cohorts provide repeated measures covering a fraction of the time range of the study. ALDs allow researchers to study developmental processes spanning long periods within a relatively shorter time framework. The common trajectory is studied by aggregating the information provided by the different cohorts. Latent change score (LCS) models provide a powerful analytical framework to analyze data from ALDs. With developmental data, LCS models can be specified using measurement occasion as the time metric. This provides a number of benefits, but has an important limitation: It makes it not possible to characterize the longitudinal changes as a function of a developmental process such as age or biological maturation. To overcome this limitation, we propose an extension of an occasion-based LCS model that includes age differences at the first measurement occasion. We conducted a Monte Carlo study and compared the results of including different transformations of the age variable. Our results indicate that some of the proposed transformations resulted in accurate expectations for the studied process across all the ages in the study, and excellent model fit. We discuss these results and provide the R code for our analysis.