门诊抗高血压用药分析

通过对天津市某医院的高血压患者发病和用药情况进行调查,了解此医院血压用药特点及其合理性和局限性。结果显示,用药频度的前三类分别是钙离子拮抗剂（CCB）、血管紧张素Ⅱ受体拮抗剂（ARB）、血管紧张素转换酶抑制剂（AcEI）;用药频度的前三个药分别是硝苯地平控释片、厄贝沙坦、贝那普利;使用一种降压药物的处方占49．25％,...     

State mood,task performance,and behavior at work: A within-persons approach

We examine the intra-individual relationships between state mood and the primary components of the individual-level criterion space (task performance, organizational citizenship behavior, and work withdrawal) as they vary within the stream of work. Using experience-sampling methods, 67 individuals in a call center responded to surveys on palmtop computers at random intervals 4–5 times each day for 3 weeks (total N = 2329). These data were matched to objective task performance obtained from organizational call records (total N = 1191). Within-persons, periods of positive mood were associated with periods of improved task performance (as evidenced by shorter call time) and engaging in work withdrawal. Trait meta-mood moderated these relationships. Specifically, individuals who attended to their moods had a stronger relationship between mood and speed of task performance (call time) and individuals able to repair their mood cognitively evidenced a weaker relationship between mood and withdrawal. Implications and the use of within-persons designs are discussed.     

机体蛋白质复杂性与植物药复方的统一

植物药复方是中医辨证施治的主要手段。药物是通过蛋白质起作用的。蛋白质复杂多样的功能与其时空的复杂演变密切相关,复方如何对蛋白质时空产生影响、如何对其结构与功能发生作用以及两者之间相互作用、相互影响的深入研究可能发现新的生命现象,为阐明疾病发病机理以及植物药的创新研制奠定理论基础和提供技术支持。     

抗血管生成靶向药物相关性高血压

高血压是抗血管生成靶向药物最常见的副作用之一,其机制和管理受到重视。本文就靶向药物导致高血压的机制进行了探讨,考虑可能与抗血管生成药物的作用靶点有关,即影响了血管内皮生长因子的功能所致;介绍临床如何进行高血压管理并建议在抗血管生成靶向药物使用过程中规范地监测、控制血压,开展相关研究。     

感觉寻求对工读生毒品使用的影响：有中介的调节效应

以523名工读生为调查对象,考察工读生毒品使用特点,并在控制相关人口学变量后,探讨感觉寻求、压力性生活事件、结交不良同伴与工读生毒品使用的关系。结果显示：（1）工读生的毒品使用行为严重,34.2%的工读生曾使用过毒品,毒品使用呈现低龄化、以吸食新型毒品为主的趋势。（2）工读生的感觉寻求是毒品使用的风险因素。（3）压力性生活事件对感觉寻求与毒品使用之间的关系具有风险增强的调节效应。（4）这种调节效应以结交不良同伴为中介变量。因此,感觉寻求对工读生毒品使用的影响是有中介的调节效应。研究结果对青少年毒品使用的预防和干预有重要的理论价值和参考价值。     

Interdependent Group Contingency Management for Cocaine-Dependent Methadone Maintenance Patients

Contingency management (CM) for drug abstinence has been applied to individuals independently even when delivered in groups. We developed a group CM intervention in which the behavior of a single, randomly selected, anonymous individual determined reinforcement delivery for the entire group. We also compared contingencies placed only on cocaine abstinence (CA) versus one of four behaviors (CA, treatment attendance, group CM attendance, and methadone compliance) selected randomly at each drawing. Two groups were formed with 22 cocaine-dependent community-based methadone patients and exposed to both CA and multiple behavior (MB) conditions in a reversal design counterbalanced across groups for exposure order. The group CM intervention proved feasible and safe. The MB condition improved group CM meeting attendance relative to the CA condition.     

重症溃疡性结肠炎药物治疗的进展与困惑

目前临床上对重症溃疡性结肠炎患者的治疗多采用糖皮质激素、免疫抑制剂、生物制剂和抗生素等,使病情得到缓解。然而,这些药物的长期疗效、副作用等需要进一步临床观察,根据病情合理选择有效药物治疗。     

The Relationship between Religiosity and Drug Use among “At Risk” Women

This study focuses on the interplay between religiosity and drug use in a sample of 250 adult women from the Atlanta, Georgia metropolitan area who were interviewed between August 1997 and August 2000. The research addresses two principal questions: (1) Is there a relationship between the level of religiosity and the amount of illegal drug use reported? (2) If so, is this relationship maintained in multivariate analysis when the effects of other potentially relevant factors like demographic characteristics, childhood maltreatment experiences, psychosocial traits, and substance user-related measures are taken into account? We found that religiosity is related to the amount of drugs women used. Four variables were retained in the final multivariate drug use prediction model: religiosity, coping with everyday stresses, number of family members who are substance abusers, and amount of oral sex. Greater amounts of drugs were used by women who were less religious, less capable of coping with stress, had more drug-abusing family members, and reported having more oral sex. Together, these items explained nearly one-fifth of the variance in the dependent variable. The implications for substance abuse prevention and intervention efforts are discussed.     

从生态自然观看细菌的耐药

伴随抗菌药物强大的抗感染疗效的同时,细菌等病原体对抗菌药物的耐药性问题日渐显露出来。运用生态自然观辨证地对细菌进行剖析,旨在突破传统思维认识细菌耐药性产生本质,从而更加有效,更加科学地控制细菌耐药的发生。     

Early Childhood Anxious Solitude and Subsequent Peer Relationships: Maternal and Cognitive Moderators

It was hypothesized that the relation between early anxious solitude and subsequent peer relations would be moderated by early relational (maternal sensitivity) and individual factors (child school readiness). Participants were 1364 children from the National Institute of Child Health and Human Development's Study of Early Child Care and Youth Development. Anxious solitude was assessed by child care providers from 2 to 4.5 years, maternal sensitivity was observed during mother–child interactions from 2 to 4.5 years, school readiness was tested at 3 years, children's interactions with a friend were observed at 4.5 years, and friendship quantity and peer rejection were assessed by first grade teachers. Results indicate that anxious solitary children who had experienced high versus low early maternal sensitivity contributed significantly more actively to positive interaction and less actively to negative interaction with a friend at 4.5 years (these results were contingent on school readiness), and had more friends and were less rejected by peers in first grade. Although high school readiness predicted interactive competency and positive peer relationships in children low in anxious solitude, these benefits were suppressed in anxious solitary children.