儿童社交回避行为：成因、测量方式及适应功能

社会退缩行为是指儿童在社会情境中抑制自己参与同伴互动并表现出独处的行为。根据不同的社交动机,社会退缩行为包含多种亚类型,其中社交回避行为这一亚类型指儿童总是表现出主动避免各种社交场合的行为。总体而言,社交回避是目前研究最少的一种,其形成的主要原因可能是由于儿童本身较高的抑郁感所致,而研究者已开始尝试以间接和直接的方式测量其水平。来自以变量为中心和以个体为中心的研究分别表明,社交回避儿童面临着最高的适应风险。鉴于这一研究领域的广泛前景,未来的研究亟需关注社交回避影响儿童适应的过程机制及其年龄发展特点,测量工具的进一步开发,直接的跨文化比较以及社交回避的干预方案开发。     

Distinguishing types of social withdrawal in children: Internalizing and externalizing outcomes of conflicted shyness versus social disinterest across childhood

Little research has examined the effect of subtypes of social withdrawal on the development of psychopathology across childhood.Parents of 493 children (220 females) completed a measure of their child’s conflicted shyness and social disinterest as well as the Child Behavior Checklist (CBCL) when their child was age 3, and again at age 6. When children were age 9, parents completed the CBCL.From 3 to 6, conflicted shyness predicted increases in anxiety symptoms in boys and girls, and predicted depressive symptoms in boys. From 6 to 9, social disinterest predicted increases in anxiety symptoms in girls and boys, and predicted increases in depressive symptoms in boys. In addition, in boys, conflicted shyness at age 6 predicted increases in externalizing symptoms at age 9.Conflicted shyness appears to be particularly problematic in early to middle childhood, while social disinterest appears to be more maladaptive in later childhood, with some differences by gender.     

Training of practitioners and beliefs about family skills in family-based prevention programmes

To ensure close adherence to the contents of a family-based cognitive-behavioural programme, and maintain a high standard of quality in its implementation, it is important that practitioners’ attitudes and beliefs regarding family skills coincide with those of the programme. This paper describes and analyses (observed) potential changes in these beliefs, after training courses held prior to the application of a prevention programme for families: the Family Competence Programme. A questionnaire was devised to examine practitioners’ beliefs regarding family skills; and completed both before and after the training course. The results point to significant changes in family dynamics, realistic expectations and active listening. Thus, it can be demonstrated that preliminary training courses promote practitioner attitudes and beliefs which are more coherent with a subsequent programme’s approach.     

在美国样本中母亲抑郁症状与儿童退缩的关系:教养行为的中介作用

本研究通过使用美国国家儿童健康与人类发育研究所的纵向研究数据建立分层线性模型,探究在儿童的早期发展中,母亲抑郁症状对儿童的社会性退缩的影响,以及母亲的教养行为在这一关系中的中介作用,结果发现：（1）在儿童24~54个月期间,随着母亲抑郁症状的升高,儿童的社会性退缩也随之升高;（2）母亲抑郁症对儿童社会性退缩的影响存在着性别差异,与女孩相比,男孩的社会性退缩更容易受到母亲抑郁症状的影响;（3）在男孩中,消极的教养行为在母亲抑郁症状与男孩的社会性退缩之间起到了中介作用,而在女孩中,这一中介作用并不显著。     

干预胆碱M受体对药物成瘾的影响及其与多巴胺的关系

药物成瘾是一类精神及行为障碍, 涉及到中枢神经系统的病变。毒蕈碱受体(Muscarinic receptor, M受体)属于胆碱能受体, 分5种亚型。行为学研究表明, 干预M受体能有效影响药物成瘾行为, 但其神经机制还亟待探索。阿片类药物与精神活性药物均能激活中枢多巴胺系统, 而M受体与多巴胺系统在多个脑区产生了交互作用。其中激动M2及M4受体抑制了多巴胺系统功能, 而激动M5受体增强了多巴胺系统功能, 与干预M2、M4、M5受体对药物成瘾行为的影响相对应。以上证据提示, 干预M受体可能通过影响多巴胺系统对药物成瘾起作用。     

反义寡核苷酸--新型抗菌药物的曙光

细菌耐药性是一个严重的医学问题,并由于数量增加的耐药菌对多种结构无关的药物产生耐药而又无新的抗生素可使用而加剧.反义寡核苷酸可特异性抑制或下调同源基因表达,从而能成为基因治疗的首选药物.多年的研究表明:反义寡核苷酸能够有效抑制细菌代谢的基础酶类及致病基因;但也存在着一些尚未完全解决的问题.建议以科学哲学的方法论和系统方法为指导,展开多学科联合的科学活动,推动新型抗菌药的研发,使基因治疗早日实现.     

Drug Tolerance, Drug Addiction, and Drug Anticipation

ABSTRACT— Environmental cues associated with drugs often elicit withdrawal symptoms and relapse to drug use. Such cues also modulate drug tolerance. The contribution of drug-associated stimuli to withdrawal and tolerance is emphasized in a Pavlovian-conditioning analysis of drug administration. Conditional responses occur in the presence of cues that have been associated with the drug in the past, such as the setting in which the drug was taken. These conditional responses mediate the expression of tolerance and withdrawal symptoms. Recently, it has become apparent that internal predrug cues, as well as environmental cues, elicit pharmacological conditional responses that contribute to tolerance and withdrawal. Such internal cues include cognitive or proprioceptive cues incidental to self-administration, drug-onset cues that are experienced shortly after administration, and emotional cues. According to the conditioning analysis, addiction treatment should incorporate learning principles to extinguish the association between stimuli (environmental and internal) present at the time of drug administration and the effects of the addictive drug.     

颅脑手术戒毒的哲学与伦理思考

颅脑手术戒毒这项新的医疗技术在社会上引起很大反响,最近被卫生部紧急叫停.从颅脑手术戒毒的历史、存在的问题、哲学及伦理方面进行反思是有必要的.把一项临床科研项目直接变换成一项临床服务项目,既未经严格科学论证也不符合伦理与法规要求.     

积极心理学在戒毒人员团体辅导中的应用

戒毒人员的心理干预与矫治正日益受到重视。积极心理学关注人们发掘自身的积极品质和积极力量,戒毒人员同样拥有的积极力量。本研究对上海市某强制隔离戒毒所的戒毒人员开展了以积极心理学为理论基础的团体心理辅导。团体辅导之后,实验组在正性情感和乐观上的得分都显著高于团体辅导前,对照组在团体辅导前后则没有显著变化。可见,将积极心理学应用于戒毒人员的团体辅导具有积极意义,团体辅导是一种有效的戒毒心理矫治方式。