道家去火毒法在《圣济总录》矿物类药炮制中的转变与利用

道家去火毒法源于道教炼丹术,是去除矿物类药火毒的特殊炮制方法。《圣济总录》部分继承和发展了道家去火毒方法,使矿物类药去火毒法成为《圣济总录》的一大特色。整理归纳《圣济总录》中的矿物类药去火毒法,对书中的方法深层次剖析,进一步阐释道家去火毒法在矿物类药炮制中发挥的具体作用;同时,深入挖掘生熟辅料、药衬、炮制装置以及特殊服法对矿物类药炮制去火毒的作用。《圣济总录》继承了道家去火毒法并进行改进,其去火毒法对现代矿物类药的炮制方法具有指导与启发意义。

     

为病患代购管制药品的情与法冲突及化解路径

为病患代购管制药品的案件在刑法上往往面临情与法的冲突。司法机关不愿意、却不得不定罪,只能在量刑时突破法律框架,尽量从轻。在刑法的实质解释下,为病患代购管制药品不成立贩卖毒品罪、非法经营罪或妨害药品管理罪,应处无罪。在刑事个案中,“情理”虽不能直接介入,但对刑法体系的适用具有批判功能。当“法理”分析的结论与公众的法直觉相违背时,应当检讨“法理”之适用过程是否出错,使刑事个案体现刑法正义,实现情与法的统一。

     

毒品原植物药用研究的“负责任创新”基本策略

毒品原植物具有药品和毒品双重属性,这种特殊性使其在科研创新活动中面临诸多伦理困境。立足解决国内毒品原植物医药研究面临的困境,参照负责任创新四维理论模型提出五个负责任行为框架,即政府主导为主、大众监督为辅,提倡多主体共同责任、资质认证与审查制度、全过程嵌入式伦理反思、建立负责任创新价值观和预后问责制,在提升创新动力方面提出部分性开放科学推进成果共享、创新监管机制以降低科研机构的风险。以中医药科研实践为基础,引入科学技术哲学思辨,为中医药毒品原植物科研创新规避风险,为提升创新动力提供有益思路。

     

同伴侵害与青少年抑郁:社会退缩的中介作用与师生关系的调节作用

研究表明同伴侵害是青少年抑郁的重要风险因素,然而其中介机制和调节机制仍有待进一步探究。本研究采用问卷法对834名青少年进行调查,考察了社会退缩在同伴侵害与青少年抑郁关系中的中介作用,以及师生关系在这一关系中的调节作用。结果发现：（1）社会退缩显著中介同伴侵害与青少年抑郁的关系;（2）师生关系显著调节中介路径“同伴侵害→社会退缩→青少年抑郁”,具体而言,相较于高水平师生关系的青少年群体而言,同伴侵害通过社会退缩影响抑郁的中介效应在低水平师生关系的青少年群体中更高。     

药物成瘾者决策缺陷的特征、机制及干预

药物成瘾者存在决策缺陷, 并表现出冲动性、风险寻求、奖赏失调、躯体内感信号缺失等特征。神经影像学研究表明药物滥用导致成瘾者背外侧前额皮层、前扣带回、眶额叶皮层、腹内侧前额皮层、杏仁核、脑岛等脑区受损, 这些损伤是引发其决策缺陷的主要原因。认知训练有利于提高个体的决策能力, 如目标管理训练和正念冥想等可以增强个体工作记忆、促进自我觉察和以目标为导向的行为; 而非侵入性脑刺激则可以直接改变与成瘾者决策相关脑区的激活状态, 从而提升与决策相关的认知功能。总体而言, 未来认知训练和非侵入性脑刺激在成瘾干预方面仍有广阔的拓展空间。     

Resilience in Scientific Research: Understanding How Natural Product Research Rebounded in an Adverse Situation

The recent declining rate in the discovery of new drugs has made natural product (NP) research—the traditional method of using living organisms to acquire drug candidates—regain its importance, despite the fact that it was once regarded as an obsolete method in the face of the exalted expectations about emerging new approaches since the 1990s. The concept of ‘resilience’ in scientific research provides a clue for understanding the dynamism of this rebound in research. Four elements may be highlighted in the context of microbial NP research in Japan: first, ‘institutional precondition’ is essential in the sense that the research must be rooted in an institutional complex involving academia, drug companies, and national policies. Second, the dual nature of the ‘attack from rival innovations’ including semiotic labeling and technical advances is examined. Third, four approaches to NP research are observed as responses to such challenges: (1) reevaluating the naturalness of NPs; (2) adopting various technical elements from their rivals; (3) shifting the emphasis from the practical pursuit of drug candidates to biological research using bioprobes; and (4) examining the uneven degree of resilience between academia and industry. Fourth and finally, NPs are viewed as an icon of cultural practice. This view may eventually open the door to questions about the meaning of ‘tradition’ in the context of general contemporary scientific research.     

The Relation Between Compulsive Sexual Behaviors and Aggression in a Substance-Dependent Population

Research supports a high comorbidity between compulsive sexual behaviors (CSBs) and substance use disorders (SUDs), which are both classified by increased impulsivity. Literature has also indicated that increased impulsivity and substance use are associated with aggression. However, no known research has examined the relationship between CSBs and aggression among a substance-dependent population. The purpose of this study was to examine this relationship. Participants included 349 male patients in treatment for SUDs. Results indicated that after controlling for alcohol and drug use and problems and age, CSBs were significantly associated with total aggression, aggressive attitudes, physical aggression, and verbal aggression. This is the first known study to examine this relationship; thus continued research is needed to extend and replicate these findings.     

农民工的工作退缩行为：基于多重嵌入和身份压力的视角

2.9亿农民工的工作退缩行为——为减少工作和组织角色而有意采取的行为(回避工作和降低努力、迟到缺勤、离职等)影响重大。为此, 本研究以资源保存理论作为“伞”理论, 整合了多重嵌入和身份压力的视角, 构建了一个全面预测农民工的工作退缩行为的模型。在该模型中, 提出了同时包含隐性和显性的工作退缩行为的测量指标体系; 构建了农民工在城市和家乡的多重嵌入对不同工作退缩行为的预测关系, 以及“农村人”和“城市人”的双重身份压力经由农民工在城市的多重嵌入对工作退缩行为的间接预测效应。本研究基于农民工样本的特异性, 构建了一个“背景化”的全面预测工作退缩行为的理论模型, 不仅弥补了微观层面农民工研究的理论空白, 也丰富了身份、多重嵌入和工作退缩行为领域的理论和文献。     

Speech presentation cues moderate frontal EEG asymmetry in socially withdrawn young adults

Socially withdrawn individuals display solitary behavior across wide contexts with both unfamiliar and familiar peers. This tendency to withdraw may be driven by either past or anticipated negative social encounters. In addition, socially withdrawn individuals often exhibit right frontal electroencephalogram (EEG) asymmetry at baseline and when under stress. In the current study we examined shifts in frontal EEG activity in young adults (N=41) at baseline, as they viewed either an anxiety-provoking or a benign speech video, and as they subsequently prepared for their own speech. Results indicated that right frontal EEG activity increased, relative to the left, only for socially withdrawn participants exposed to the anxious video. These results suggest that contextual affective cues may prime an individual's response to stress, particularly if they illustrate or substantiate an anticipated negative event.