哮喘控制稳定后如何减停糖皮质激素

糖皮质激素是最有效的抗气道炎症药物,吸入糖皮质激素(ICS)是首选哮喘控制药物。由于治疗后达到哮喘临床控制(症状、肺功能)需要一定时间,ICS达到一定剂量后量效曲线较平坦,而全身不良反应却逐渐增加。因此,达到临床控制后在长期监测下至少维持哮喘控制3个月以上,开始减少50%ICS剂量,直至ICS减至最低维持剂量。如为ICS加另一种控制药(长效β2受体激动剂、白三烯调节剂、缓释茶碱)联合治疗达到控制者,在ICS减至最低剂量时再停用另一种控制药。应用最低剂量ICS维持控制达1年方可考虑停药。     

ESBLs大肠埃希菌Ⅰ类整合子与耐药性关系

整合子通过位点特异的基因重组在临床细菌耐药性传播中起重要作用。根据整合酶基因intⅠ的序列不同将整合子划分成4种类型,其中第一类整合子最常见,决定着细菌的多重耐药。产ESBLs菌株在整合予水平转移的介导下能增加捕获这些基因盒的可能性,更有利于耐药基因的传递和扩散。     

242例吸毒女性自尊及背景资料的调查与分析

运用自尊量表和背景资料调查问卷对甘肃省两大戒毒所242例吸毒女性进行测查,结果表明：（1）年龄、婚姻状况、文化程度、经济收入水平等因素与吸毒女性自尊评分无显著相关;（2）回归分析显示,人际关系因子对吸毒女性自尊评分有显著影响,认知、行为因子对其自尊评分的影响没有达到显著性水平;（3）文化程度不高,无固定的经济收入,失恋或离婚等因素是吸毒或吸毒成瘾的重要关联因素。     

吸毒者回归社会的过程:归属与认同的剥夺

该研究通过回顾性研究与问卷测量的方法,对吸毒者的认同感、归属感与复吸风险进行了分析和探讨,并对他们的生存状况进行了初步调查,结果表明:不利的社会处境是高复吸风险的诱发因素,戒毒人员回归社会后的生存状况不容乐观;吸毒者的自我认同和社会认同程度都显著低于健康人群,社会缺乏对戒毒人员有效的社会支持;归属剥夺是导致复吸的危险性因素,戒毒人员回归社会之后缺乏亲密的人际交往和情感交流。     

分配不公正下的退缩行为：程序公正和互动公正的影响

以160名中学教师为被试,采用2×2的完全随机设计,以模拟故事（scenarios）的方法呈现刺激,研究了在职称评定中分配不公正的前提下,程序公正/不公正,互动公正/不公正对教师的退缩行为（消极怠工、拒绝帮助、离职、对校长的消极态度）的影响。结果表明,在分配不公正条件下：（1）程序公正、互动公正均影响教师的消极怠工程度;（2）程序公正、互动公正均影响教师的拒绝帮助行为程度,而且交互作用显著;（3）互动公正影响教师对上司的消极态度,程序公正无显著影响;（4）程序公正和互动公正对离职意愿影响均不显著     

Resilience in Scientific Research: Understanding How Natural Product Research Rebounded in an Adverse Situation

The recent declining rate in the discovery of new drugs has made natural product (NP) research—the traditional method of using living organisms to acquire drug candidates—regain its importance, despite the fact that it was once regarded as an obsolete method in the face of the exalted expectations about emerging new approaches since the 1990s. The concept of ‘resilience’ in scientific research provides a clue for understanding the dynamism of this rebound in research. Four elements may be highlighted in the context of microbial NP research in Japan: first, ‘institutional precondition’ is essential in the sense that the research must be rooted in an institutional complex involving academia, drug companies, and national policies. Second, the dual nature of the ‘attack from rival innovations’ including semiotic labeling and technical advances is examined. Third, four approaches to NP research are observed as responses to such challenges: (1) reevaluating the naturalness of NPs; (2) adopting various technical elements from their rivals; (3) shifting the emphasis from the practical pursuit of drug candidates to biological research using bioprobes; and (4) examining the uneven degree of resilience between academia and industry. Fourth and finally, NPs are viewed as an icon of cultural practice. This view may eventually open the door to questions about the meaning of ‘tradition’ in the context of general contemporary scientific research.     

The Relation Between Compulsive Sexual Behaviors and Aggression in a Substance-Dependent Population

Research supports a high comorbidity between compulsive sexual behaviors (CSBs) and substance use disorders (SUDs), which are both classified by increased impulsivity. Literature has also indicated that increased impulsivity and substance use are associated with aggression. However, no known research has examined the relationship between CSBs and aggression among a substance-dependent population. The purpose of this study was to examine this relationship. Participants included 349 male patients in treatment for SUDs. Results indicated that after controlling for alcohol and drug use and problems and age, CSBs were significantly associated with total aggression, aggressive attitudes, physical aggression, and verbal aggression. This is the first known study to examine this relationship; thus continued research is needed to extend and replicate these findings.     

同伴侵害与青少年抑郁:社会退缩的中介作用与师生关系的调节作用

研究表明同伴侵害是青少年抑郁的重要风险因素,然而其中介机制和调节机制仍有待进一步探究。本研究采用问卷法对834名青少年进行调查,考察了社会退缩在同伴侵害与青少年抑郁关系中的中介作用,以及师生关系在这一关系中的调节作用。结果发现：（1）社会退缩显著中介同伴侵害与青少年抑郁的关系;（2）师生关系显著调节中介路径“同伴侵害→社会退缩→青少年抑郁”,具体而言,相较于高水平师生关系的青少年群体而言,同伴侵害通过社会退缩影响抑郁的中介效应在低水平师生关系的青少年群体中更高。     

农民工的工作退缩行为：基于多重嵌入和身份压力的视角

2.9亿农民工的工作退缩行为——为减少工作和组织角色而有意采取的行为(回避工作和降低努力、迟到缺勤、离职等)影响重大。为此, 本研究以资源保存理论作为“伞”理论, 整合了多重嵌入和身份压力的视角, 构建了一个全面预测农民工的工作退缩行为的模型。在该模型中, 提出了同时包含隐性和显性的工作退缩行为的测量指标体系; 构建了农民工在城市和家乡的多重嵌入对不同工作退缩行为的预测关系, 以及“农村人”和“城市人”的双重身份压力经由农民工在城市的多重嵌入对工作退缩行为的间接预测效应。本研究基于农民工样本的特异性, 构建了一个“背景化”的全面预测工作退缩行为的理论模型, 不仅弥补了微观层面农民工研究的理论空白, 也丰富了身份、多重嵌入和工作退缩行为领域的理论和文献。