门诊抗高血压用药分析

通过对天津市某医院的高血压患者发病和用药情况进行调查,了解此医院血压用药特点及其合理性和局限性。结果显示,用药频度的前三类分别是钙离子拮抗剂（CCB）、血管紧张素Ⅱ受体拮抗剂（ARB）、血管紧张素转换酶抑制剂（AcEI）;用药频度的前三个药分别是硝苯地平控释片、厄贝沙坦、贝那普利;使用一种降压药物的处方占49．25％,...     

机体蛋白质复杂性与植物药复方的统一

植物药复方是中医辨证施治的主要手段。药物是通过蛋白质起作用的。蛋白质复杂多样的功能与其时空的复杂演变密切相关,复方如何对蛋白质时空产生影响、如何对其结构与功能发生作用以及两者之间相互作用、相互影响的深入研究可能发现新的生命现象,为阐明疾病发病机理以及植物药的创新研制奠定理论基础和提供技术支持。     

抗血管生成靶向药物相关性高血压

高血压是抗血管生成靶向药物最常见的副作用之一,其机制和管理受到重视。本文就靶向药物导致高血压的机制进行了探讨,考虑可能与抗血管生成药物的作用靶点有关,即影响了血管内皮生长因子的功能所致;介绍临床如何进行高血压管理并建议在抗血管生成靶向药物使用过程中规范地监测、控制血压,开展相关研究。     

感觉寻求对工读生毒品使用的影响：有中介的调节效应

以523名工读生为调查对象,考察工读生毒品使用特点,并在控制相关人口学变量后,探讨感觉寻求、压力性生活事件、结交不良同伴与工读生毒品使用的关系。结果显示：（1）工读生的毒品使用行为严重,34.2%的工读生曾使用过毒品,毒品使用呈现低龄化、以吸食新型毒品为主的趋势。（2）工读生的感觉寻求是毒品使用的风险因素。（3）压力性生活事件对感觉寻求与毒品使用之间的关系具有风险增强的调节效应。（4）这种调节效应以结交不良同伴为中介变量。因此,感觉寻求对工读生毒品使用的影响是有中介的调节效应。研究结果对青少年毒品使用的预防和干预有重要的理论价值和参考价值。     

Interdependent Group Contingency Management for Cocaine-Dependent Methadone Maintenance Patients

Contingency management (CM) for drug abstinence has been applied to individuals independently even when delivered in groups. We developed a group CM intervention in which the behavior of a single, randomly selected, anonymous individual determined reinforcement delivery for the entire group. We also compared contingencies placed only on cocaine abstinence (CA) versus one of four behaviors (CA, treatment attendance, group CM attendance, and methadone compliance) selected randomly at each drawing. Two groups were formed with 22 cocaine-dependent community-based methadone patients and exposed to both CA and multiple behavior (MB) conditions in a reversal design counterbalanced across groups for exposure order. The group CM intervention proved feasible and safe. The MB condition improved group CM meeting attendance relative to the CA condition.     

Combining additive representations on subsets into an overall representation

Many traditional conjoint representations of binary preferences are additively decomposable, or additive for short. An important generalization arises under rank-dependence, when additivity is restricted to cones with a fixed ranking of components from best to worst (comonotonicity), leading to configural weighting, rank-dependent utility, and rank- and sign-dependent utility (prospect theory). This paper provides a general result showing how additive representations on an arbitrary collection of comonotonic cones can be combined into one overall representation that applies to the union of all cones considered. The result is applied to a new paradigm for decision under uncertainty developed by Duncan Luce and others, which allows for violations of basic rationality properties such as the coalescing of events and other framing conditions. Through our result, a complete preference foundation of a number of new models by Luce and others can be obtained. We also show how additive representations on different full product sets can be combined into a representation on the union of these different product sets.     

Peak-End rule versus average utility: How utility aggregation affects evaluations of experiences

The “Peak-End rule” which averages only the most extreme (Peak) and the final (End) impressions, is often a better predictor of overall evaluations of experiences than average impressions. We investigate the similarity between the evaluations of experiences based on Peak-End and average impressions. We show that the use of the Peak-End rule in cross-experience comparisons can be compatible with preferences for experiences that are better on average. Two conditions are shown to make rankings of experiences similar regardless of the aggregation rule: (i) the individual heterogeneity in the perception of stimuli, and (ii) the persistence in impressions. We describe their effects theoretically, and obtain empirical estimates using data from previous research. Higher estimates are shown to increase correlational measures of association between the Peak-End and average impressions. The high association per se is shown to be not only a theoretical possibility, but an empirical fact.     

重症溃疡性结肠炎药物治疗的进展与困惑

目前临床上对重症溃疡性结肠炎患者的治疗多采用糖皮质激素、免疫抑制剂、生物制剂和抗生素等,使病情得到缓解。然而,这些药物的长期疗效、副作用等需要进一步临床观察,根据病情合理选择有效药物治疗。     

厌而避额外之“利”；喜而趋额外之“害”

趋利避害是生物的本能。《管子·禁藏》云：夫凡人之情, 见利莫能勿就, 见害莫能勿避。“两利相权取其重, 两害相权取其轻”是规范性决策理论的一基本原则。本研究以金钱作为奖赏或惩罚刺激, 检验人们能否理性地遵循“价值最大化”原则。在实验中, 主试以检查硬币生产年代的数目为由, 让被试逐枚地感受两个金钱序列：10元硬币序列(由20枚五角硬币组成)和10.3元硬币序列(由20枚五角硬币和3枚一角硬币组成),随后评定获得(或损失)各金钱序列的高兴(或不高兴)程度, 并从中选择一金钱序列(与硬币等值的金钱)作为其奖赏(或惩罚)。实验为2 (3枚一角硬币在序列首vs. 3枚一角硬币在序列尾)´2(先检查10元硬币序列vs. 先检查10.3元硬币序列)´2(损失vs. 获得)三因素设计, 每种条件随机分配15名商学院学生被试。结果表明, 被试倾向选择获益少(10元)和损失多(-10.3元)的金钱序列; 且获益大(10.3元)时高兴程度小, 损失小(-10元)时不高兴程度大。这一结果意味着：“聊”并不胜于“无”,反而是“无”胜于“聊”。其中, 伴随着违背价值最大化原则所产生的情感亦有悖逻辑。负性情感的引发一般有其“逻辑正确”的原因(如, 无惠而不乐); 而引发本研究负性情感的原因实属“逻辑错误”(如, 惠多而不乐)。这种不曾被定义而类似于“冤”的情感不仅见于个人,也见于民族、国家间的持续交往, 值得进一步研究。     

On the equivalence between elimination-by-aspects and generalised extreme value models of choice behaviour

Elimination-by-aspects and generalised extreme value offer competing paradigms for the representation of a common behaviour, that of individual discrete choice. Observing certain consistencies in their mathematical structure, several eminent authors have commented on the degree of equivalence between the two paradigms. Most contributions to this debate have, however, been less than definitive. More fundamentally, the contributions lack consensus. We advance the debate by establishing formal mathematical conditions under which three-alternative tree models from the two paradigms are exactly equivalent. We then extend our analysis to consider more general models, showing that equivalence can be established for general tree models, but not for cross-nested models.