Similar consumption and responding across single and multiple sources of drug

Two experiments were conducted to assess whether total response output and total consumption would be similar when drugs are available from single and multiple sources of reinforcement, as predicted by behavioral economics. In Experiment 1, cigarette-deprived smokers were exposed to a concurrent-chains schedule in which equal fixed-ratio schedules served as the initial links, and different reinforcer magnitudes (i.e., number of cigarette puffs) were arranged across alternatives. After the session, obtained unit price was calculated and imposed in the next session when a different number of puffs was available according to a single fixed-ratio schedule. Thus, the unit price at which cigarette puffs could be earned was yoked within subjects across the single and concurrent-chains schedules. When plotted as a function of unit price, similar consumption and response rates were usually obtained across these schedules. Experiment 2 addressed a weakness of Experiment 1, namely, that responding was allocated exclusively to the larger reinforcer magnitude in concurrent-chains conditions, and therefore this schedule may have functioned as a single schedule. In Experiment 2, subjects were instructed to alternate responding between the two alternative schedules. Instructions produced approximately equal response allocation between the two alternatives. Again, similar consumption and response rates were observed across the single and instructed concurrent-chains schedules. These findings are discussed in the context of direct effects and behavioral economics perspectives of drug self-administration.     

Behavior of rats under fixed consecutive number schedules: effects of drugs of abuse.

Four rats responded under a simple fixed consecutive number schedule in which eight or more consecutive responses on the run lever, followed by a single response on the reinforcement lever, produced the food reinforcer. Under this simple schedule, dose-response curves were determined for diazepam, morphine, pentobarbital, and phencyclidine. The rats were then trained to respond under a multiple fixed consecutive number schedule in which a discriminative stimulus signaled when the response requirement on the run lever had been completed in one of the two fixed consecutive number component schedules. Under control conditions, the percentage of reinforced runs under the multiple-schedule component with the discriminative stimulus added was much higher than the percentage of reinforced runs under the multiple-schedule component without the discriminative stimulus. All of the drugs decreased the percentage of reinforced runs under each of the fixed consecutive number schedules by increasing the conditional probability of short run lengths. This effect was most consistently produced by morphine. The drugs produced few differences in responding between the multiple fixed consecutive number components. Responding under the simple fixed consecutive number schedule, however, was affected at lower doses of the drugs than was responding under the same fixed consecutive number schedule when it was a component of the multiple schedule. This result may be due to the difference in schedule context or, perhaps, to the order of the experiments.     

Comorbidity of drug abuse treatment

Research has suggested that comorbidity, the concurrence of substance abuse disorders with other psychiatric disorders, may have prognostic value and important implications for the treatment of substance abuse. Knowledge of the prevalence of comorbid disorder is important because it will enable treatment services to be appropriately configured and designed for clinical drug treatment populations. The form and duration of comorbidity may be influenced by a variety of factors, which include the class of drug being abused, the duration of drug use, the individual sensitivity to drug effects, and whether the drug effects are acute or due to withdrawal or residual conditions. This paper addresses three important scientific questions: (1) What is the prevalence of comorbid disorders in a drug abuser population? (2) What is the stability of psychiatric diagnoses in a drug abuser population? (3) Does the existence of a comorbid disorder influence the outcome of drug abuse treatment?     

Taboo Trade-offs: Reactions to Transactions That Transgress the Spheres of Justice

Taboo trade-offs violate deeply held normative intuitions about the integrity, even sanctity, of certain relationships and the moral-political values underlying those relationships. For instance, if asked to estimate the monetary worth of one's children, of one's loyalty to one's country, or of acts of friendship, people find the questions more than merely confusing or cognitively intractable: they find such questions themselves morally offensive. This article draws on Fiske's relational theory and Tetlock's value pluralism model: (a) to identify the conditions under which people are likely to treat trade-offs as taboo; (b) to describe how people collectively deal with trade-offs that become problematic; (c) to specify the conceptual components of moral outrage and the factors that affect the intensity of reactions to various explicit trade-offs; (d) to explore the various strategies that decision-makers—required by resource scarcity and institutional roles to confront taboo trade-offs—use to deflect the wrath of censorious observers; (e) to offer a method of dispute resolution based on pluralism.     

AN EFFECTIVENESS TRIAL OF CONTINGENCY MANAGEMENT IN A FELONY PREADJUDICATION DRUG COURT

This study evaluated a contingency management (CM) program in a drug court. Gift certificates for compliance were delivered at 4‐ to 6‐week intervals (total value = $390.00). Participants in one condition earned gift certificates that escalated by $5.00 increments. Participants in a second condition began earning higher magnitude gift certificates, and the density of reinforcement was gradually decreased. No main effects of CM were detected, which appears to be attributable to a ceiling effect from the intensive contingencies already delivered in the drug court and the low density of reinforcement. Preplanned interaction analyses suggested that participants with more serious criminal backgrounds might have performed better in the CM conditions. This suggests that CM programs may be best suited for more incorrigible drug offenders.     

Drug addicts in therapy—changes in life space in the course of one year

In a residential community treatment setting, moods and emotional states of drug addicts were explored over a 1‐year period. The specific form of treatment of heroin addiction employed in the communities is based on the importance of interpersonal relationships for psychosocial transition. Twenty‐nine participants reported current mood, emotions, attributions, and motive activation using a time‐sampling diary for 2 weeks at the beginning of the treatment, and 6 and 12 months later. Results show an increase in positive emotions, and in subjective strength and freedom. Furthermore, participants report higher self‐esteem and use less fatalistic attributions. This is interpreted as indicating successful transition processes in terms of higher autonomy, a more extended life space and increased levels of realism. Copyright © 2002 John Wiley & Sons, Ltd.     

吸毒者：病人还是罪犯

如何认定吸毒者的社会身份是禁毒工作中亟待解决的问题。概述常见的毒品和吸毒的流行趋势。通过分析吸毒与医学和犯罪的关系,了解吸毒是病态还是犯罪。提出如何正确对待吸毒与戒毒,社会有关人员有责任关怀吸毒品走私案者,消除偏见,给予他们应有的帮助和治疗。     

药物不良反应补偿体系国际比较研究

药品在治疗疾病过程中有着不可或缺的作用,但药品在使用过程中也往往容易发生药物不良反应,并造成患者很重的经济负担,很多国家都针对药品不良反应建立救济保险制度。从基金筹资、补偿制度、管理等角度对国际上几个国家的药物不良反应补偿体系进行分析,以期我们在建立自己相应的药物不良反应补偿体系时有所借鉴。     

La motivation et son ancrage utilitaire/désirable dans l’évaluation

Motivation has an important place among the personal characteristics that professional assessors take in account. A first study shows that different professionals do not choose the same criteria to assess motivation and also shows that normative factors affect their judgement. Then a series of studies focuses on the valorization of intrinsic motivation and on the anchoring in utility / desirability of this attribution of value. It appears that, compared with extrinsically motivated applicants, intrinsically motivated applicants are rather described by judges with desirable traits than with utility traits. This result is found as well with professionals and non professional respondents. So it seems that the valorization of intrinsic motivation would be more anchored in desirability than in utility, which is a difference with the norm of internality that is clearly anchored in utility.     

二级强化程序在药物成瘾研究中的应用

二级强化程序是一种以物质的强化效应为基础,评价药物的精神依赖性潜力的方法,将其应用到自身给药实验中,即为二级强化自身给药模型。在这个模型中,动物在条件性刺激的影响下按压杠杆以寻求药物的行为反映了其对成瘾性药物的渴求。使用二级强化程序,人们发现：条件性刺激既能够影响觅药行为的获得和保持,也能够影响这种行为的消退;伏隔核的核区、杏仁核基底外侧部和内侧前额皮层等部位在药物相关的条件性刺激诱导动物产生觅药行为的过程中起重要作用。二级强化程序的应用为开发治疗药物成瘾的物质提供了一条新思路