Cumulative parenting stress across the preschool period: relations to maternal parenting and child behaviour at age 5

Despite increasing interest in the effects of parenting stress on children and families, many questions remain regarding the nature of parenting stress and the mechanism through which stress exerts its influence across time. In this study, cumulative parenting stress was assessed across the preschool period in a sample of 125 typically developing children and their mothers. Indices of parenting stress included both major life events stress‐assessed annually from age 3 to 5, and parenting daily hassles assessed every 6 months across the same period. Naturalistic home observations were conducted when children were age 5, during which measures of parent and child interactive behaviour as well as dyadic pleasure and dyadic conflict were obtained. Mothers also completed the CBCL to assess children's behaviour problems. Results indicated that parenting daily hassles and major life stress are relatively stable across the preschool period. Both cumulative stress indices also proved to be important predictors of parent and child behaviour and dyadic interaction, although the predictions were somewhat differential. Despite meaningful relations between the stress factors and child well being, no evidence was found to support the premise that parent behaviour mediates the association between parenting stress and child outcomes. Results are discussed within a developmental framework to understand the stability and complexity of cumulative stress associations to early parent–child relationships. Copyright © 2005 John Wiley & Sons, Ltd.     

Drug Tolerance, Drug Addiction, and Drug Anticipation

ABSTRACT— Environmental cues associated with drugs often elicit withdrawal symptoms and relapse to drug use. Such cues also modulate drug tolerance. The contribution of drug-associated stimuli to withdrawal and tolerance is emphasized in a Pavlovian-conditioning analysis of drug administration. Conditional responses occur in the presence of cues that have been associated with the drug in the past, such as the setting in which the drug was taken. These conditional responses mediate the expression of tolerance and withdrawal symptoms. Recently, it has become apparent that internal predrug cues, as well as environmental cues, elicit pharmacological conditional responses that contribute to tolerance and withdrawal. Such internal cues include cognitive or proprioceptive cues incidental to self-administration, drug-onset cues that are experienced shortly after administration, and emotional cues. According to the conditioning analysis, addiction treatment should incorporate learning principles to extinguish the association between stimuli (environmental and internal) present at the time of drug administration and the effects of the addictive drug.     

颅脑手术戒毒的哲学与伦理思考

颅脑手术戒毒这项新的医疗技术在社会上引起很大反响,最近被卫生部紧急叫停.从颅脑手术戒毒的历史、存在的问题、哲学及伦理方面进行反思是有必要的.把一项临床科研项目直接变换成一项临床服务项目,既未经严格科学论证也不符合伦理与法规要求.     

门诊抗高血压用药分析

通过对天津市某医院的高血压患者发病和用药情况进行调查,了解此医院血压用药特点及其合理性和局限性。结果显示,用药频度的前三类分别是钙离子拮抗剂（CCB）、血管紧张素Ⅱ受体拮抗剂（ARB）、血管紧张素转换酶抑制剂（AcEI）;用药频度的前三个药分别是硝苯地平控释片、厄贝沙坦、贝那普利;使用一种降压药物的处方占49．25％,...     

抗血管生成靶向药物相关性高血压

高血压是抗血管生成靶向药物最常见的副作用之一,其机制和管理受到重视。本文就靶向药物导致高血压的机制进行了探讨,考虑可能与抗血管生成药物的作用靶点有关,即影响了血管内皮生长因子的功能所致;介绍临床如何进行高血压管理并建议在抗血管生成靶向药物使用过程中规范地监测、控制血压,开展相关研究。     

感觉寻求对工读生毒品使用的影响：有中介的调节效应

以523名工读生为调查对象,考察工读生毒品使用特点,并在控制相关人口学变量后,探讨感觉寻求、压力性生活事件、结交不良同伴与工读生毒品使用的关系。结果显示：（1）工读生的毒品使用行为严重,34.2%的工读生曾使用过毒品,毒品使用呈现低龄化、以吸食新型毒品为主的趋势。（2）工读生的感觉寻求是毒品使用的风险因素。（3）压力性生活事件对感觉寻求与毒品使用之间的关系具有风险增强的调节效应。（4）这种调节效应以结交不良同伴为中介变量。因此,感觉寻求对工读生毒品使用的影响是有中介的调节效应。研究结果对青少年毒品使用的预防和干预有重要的理论价值和参考价值。     

Associations between Maternal Attention-Deficit/Hyperactivity Disorder Symptoms and Parenting

Mothers of children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for an ADHD diagnosis themselves, which is likely associated with impairments in parenting. The present study utilized a multi-method assessment of maternal ADHD and parenting to examine the extent to which maternal ADHD symptoms are associated with maladaptive parenting. Participants included 70 6–10 year old children with DSM-IV ADHD and their biological mothers. Results suggested that mothers with higher levels of ADHD symptoms reported lower levels of involvement and positive parenting and higher levels of inconsistent discipline. During observed parent–child interactions, maternal ADHD symptoms were negatively associated with positive parenting, and positively associated with negative parenting and repeated commands before giving the child an opportunity to comply. Given prior research suggesting that maladaptive parenting behaviors are risk factors for the later development of conduct problems among children with ADHD, these findings have important clinical implications for family-based assessment and treatment of ADHD.     

Cross-modal interactions in the experience of musical performances: physiological correlates

This experiment was conducted to investigate cross-modal interactions in the emotional experience of music listeners. Previous research showed that visual information present in a musical performance is rich in expressive content, and moderates the subjective emotional experience of a participant listening and/or observing musical stimuli [Vines, B. W., Krumhansl, C. L., Wanderley, M. M., & Levitin, D. J. (2006). Cross-modal interactions in the perception of musical performance. Cognition, 101, 80--113.]. The goal of this follow-up experiment was to replicate this cross-modal interaction by investigating the objective, physiological aspect of emotional response to music measuring electrodermal activity. The scaled average of electrodermal amplitude for visual-auditory presentation was found to be significantly higher than the sum of the reactions when the music was presented in visual only (VO) and auditory only (AO) conditions, suggesting the presence of an emergent property created by bimodal interaction. Functional data analysis revealed that electrodermal activity generally followed the same contour across modalities of presentation, except during rests (silent parts of the performance) when the visual information took on particular salience. Finally, electrodermal activity and subjective tension judgments were found to be most highly correlated in the audio-visual (AV) condition than in the unimodal conditions. The present study provides converging evidence for the importance of seeing musical performances, and preliminary evidence for the utility of electrodermal activity as an objective measure in studies of continuous music-elicited emotions.     

Interdependent Group Contingency Management for Cocaine-Dependent Methadone Maintenance Patients

Contingency management (CM) for drug abstinence has been applied to individuals independently even when delivered in groups. We developed a group CM intervention in which the behavior of a single, randomly selected, anonymous individual determined reinforcement delivery for the entire group. We also compared contingencies placed only on cocaine abstinence (CA) versus one of four behaviors (CA, treatment attendance, group CM attendance, and methadone compliance) selected randomly at each drawing. Two groups were formed with 22 cocaine-dependent community-based methadone patients and exposed to both CA and multiple behavior (MB) conditions in a reversal design counterbalanced across groups for exposure order. The group CM intervention proved feasible and safe. The MB condition improved group CM meeting attendance relative to the CA condition.     

The Relationship between Religiosity and Drug Use among “At Risk” Women

This study focuses on the interplay between religiosity and drug use in a sample of 250 adult women from the Atlanta, Georgia metropolitan area who were interviewed between August 1997 and August 2000. The research addresses two principal questions: (1) Is there a relationship between the level of religiosity and the amount of illegal drug use reported? (2) If so, is this relationship maintained in multivariate analysis when the effects of other potentially relevant factors like demographic characteristics, childhood maltreatment experiences, psychosocial traits, and substance user-related measures are taken into account? We found that religiosity is related to the amount of drugs women used. Four variables were retained in the final multivariate drug use prediction model: religiosity, coping with everyday stresses, number of family members who are substance abusers, and amount of oral sex. Greater amounts of drugs were used by women who were less religious, less capable of coping with stress, had more drug-abusing family members, and reported having more oral sex. Together, these items explained nearly one-fifth of the variance in the dependent variable. The implications for substance abuse prevention and intervention efforts are discussed.