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91.
The ethical issues in conducting research on preventing HIV infection are among the most complex of any area of human subjects research. This article is an update of a 1987 article that addressed potential conflicts between research design and ethics with respect to AIDS prevention among injecting drug users. The present article reviews current ethical issues that arise in the design and conduct of HIV/AIDS prevention research focused on injecting drug users. Disclaimer: The content of this publication is solely the responsibility of the authors and does not necessarily represent the views of the Beth Israel Medical Center or Johns Hopkins University.  相似文献   
92.
This study examined the patterns of drug use and criminal activities among Latino arrestees. The findings indicate that while the prevalence of drug use at time of arrest, and in the prior 12 months were significantly lower for Latinos compared to Whites and Blacks, drug use still is of concern for this ethnic group. Almost 50% of Latinos reported drug use in the last year, and more importantly, they were more likely to report using dangerous drugs such as cocaine, heroin, and PCP than any other ethnic group. These findings are even more alarming considering that, for the most part, Latino drug users were treatment-naive, and that less than half perceived a need for drug treatment. Regarding criminal activities, Latinos were less likely to have a history of prior arrests and to have been arrested in the year prior to the interview than any other ethnic group. Interestingly, those immigrants who have resided in the U.S. for less than 1 year were significantly more likely to have been charged with drug-related crimes. U.S. born Latinos were more likely to have been arrested for property crimes, while Central American immigrants were more likely than any other Latino group to have been arrested for violent and domestic violence crimes. Treatment and policy implications of these findings are discussed.  相似文献   
93.
To determine whether Beck Depression Inventory (BDI) responses could be influenced by an instructional set or by changing the item order, 198 college students were randomly assigned to one of four conditions: instructions designed to facilitate or inhibit responding, along with standard vs. reordered symptom questions. A 2×2 ANCOVA found a main effect only for the inhibitory message. The suppression of scores by the inhibitor instructional set suggests caution regarding possible demand characteristics when using the BDI with this population and should be further studied with clinically symptomatic samples.  相似文献   
94.
The effect of ethanol on the cigarette smoking of alcoholic subjects was studied in a residential laboratory. During daily 6-hr sessions, cigarettes were obtained either by request to the ward staff or by operation of a lever (fixed-ratio 5 or 10). In a mixed sequence across days, sessions involved ingestion of either vehicle (orange juice or vehicle plus ethanol (133.7 g). During ethanol sessions, the rate of cigarette smoking increased from 26% to 117% of vehicle levels. A series of control studies eliminated a number of potential behavorial mechanisms for the observed effect and indicated that the ethanol-induced increase in cigarette smoking occurred under a variety of experimental conditions: (1) when smoking could not occur concurrently with ethanol or vehicle consumption; (2) when subjects were not allowed to socialize; (3) when ingestion of ethanol or vehicle was scheduled for a number of consecutive days; (4) when various doses of ethanol were administered under blind conditions. In control experiments, weighing unsmoked tobacco and counting the number of puffs per cigarette indicated the effect was not due to smoking less of each cigarette. The effect was not limited to the experimental sessions alone, since total daily smoking was higher on ethanol days than vehicle days.  相似文献   
95.
Pigeons were trained to track different key colors, depending on whether they had been injected with phencyclidine or saline prior to the session. A second-order schedule was used to generate large numbers of responses prior to the initial food delivery. The procedure offers several advantages over traditional procedures for studying drug discrimination.  相似文献   
96.
The present research was concerned with identifying and validating the problematic interpersonal situations of male veteran drug addicts. In Study I, 20 addicts self-monitored the situations with which they had difficulty coping and their associated characteristics throughout a 2-week period. Fifty situations were obtained and then rewritten into specific interpersonal scenarios. In Study II, a second group of 36 addicts and a comparison group of 20 disabled veterans rated the commonality and difficulty of each scenario along seven-point scales. Univariate ANOVAs found that five scenarios received ratings greater than four on both scales and were associated with significantly higher ratings by the addicts. These preliminary scenarios may serve as role-play situations during social-skills assessment and training and may provide further information regarding the interpersonal determinants of relapse occasioned in the natural environment. The need for controlled comparison studies using behavioral measures and an overall improvement in the methodological rigor of research in the area is discussed.The authors acknowledge the editorial comments of Ted D. Nirenberg, Ph.D., on an earlier draft of this paper. Portions of these data were presented at the Fifth World Congress on Behavior Therapy, Washington, DC.  相似文献   
97.
A positive reinforcement contingency increased opioid abstinence during outpatient dose tapering (4, 2, then 0 mg/day during Weeks 1 through 3) in non‐treatment‐seeking heroin‐dependent volunteers who had been maintained on buprenorphine (8 mg/day) during an inpatient research protocol. The control group (n = 12) received $4.00 for completing assessments at each thrice‐weekly visit during dose tapering; 10 of 12 lapsed to heroin use 1 day after discharge. The abstinence reinforcement group (n = 10) received $30.00 for each consecutive opioid‐free urine sample; this significantly delayed heroin lapse (median, 15 days).  相似文献   
98.
The reinforcer pathologies model of addiction posits that two characteristic patterns of operant behavior characterize addiction. Specifically, individuals suffering from addiction have elevated levels of behavioral economic demand for their substances of abuse and have an elevated tendency to devalue delayed rewards (reflected in high delay discounting rates). Prior research has demonstrated that these behavioral economic markers are significant predictors of many of college students' alcohol-related problems. Delay discounting, however, is a complex behavioral performance likely undergirded by multiple behavioral processes. Emerging analytical approaches have isolated the role of participants' sensitivity to changes in reinforcer magnitude and changes in reinforcer delay. The current study uses these analytic approaches to compare participants' discounting of money versus alcohol, and to build regression models that leverage these new insights to predict a wider range of college students' alcohol related problems. Using these techniques, we were able to 1) demonstrate that individuals differed in their sensitivity to magnitudes of alcohol versus money, but not sensitivity to delays to those commodities and 2) that we could use our behavioral economic measures to predict a range of students' alcohol related problems.  相似文献   
99.
通过对本地一所三级甲等医院进行的围手术期抗菌药物的干预对照研究,用SPSS软件对470个手术病例的调查资料进行了统计分析,加强抗菌药物的用药管理及进行用药干预,能在对住院时间和手术切口感染率无影响的同时,明显降低手术病例的药品费用,特别是抗茵药品的费用,减轻患者负担。  相似文献   
100.
克服肿瘤干细胞耐药性的策略和思路   总被引:1,自引:1,他引:0  
肿瘤干细胞(cancersterncells,CSCs)是肿瘤细胞的祖细胞。已有的研究表明,肿瘤干细胞对多种化疗药物具有耐药性,是导致肿瘤治疗后复发的根源。研究针对肿瘤干细胞的治疗方法,克服肿瘤干细胞耐药性,将给肿瘤治疗模式带来全新的改变,有望彻底改善肿瘤患者的预后。  相似文献   
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