ESBLs大肠埃希菌Ⅰ类整合子与耐药性关系

整合子通过位点特异的基因重组在临床细菌耐药性传播中起重要作用。根据整合酶基因intⅠ的序列不同将整合子划分成4种类型,其中第一类整合子最常见,决定着细菌的多重耐药。产ESBLs菌株在整合予水平转移的介导下能增加捕获这些基因盒的可能性,更有利于耐药基因的传递和扩散。     

242例吸毒女性自尊及背景资料的调查与分析

运用自尊量表和背景资料调查问卷对甘肃省两大戒毒所242例吸毒女性进行测查,结果表明：（1）年龄、婚姻状况、文化程度、经济收入水平等因素与吸毒女性自尊评分无显著相关;（2）回归分析显示,人际关系因子对吸毒女性自尊评分有显著影响,认知、行为因子对其自尊评分的影响没有达到显著性水平;（3）文化程度不高,无固定的经济收入,失恋或离婚等因素是吸毒或吸毒成瘾的重要关联因素。     

吸毒者回归社会的过程:归属与认同的剥夺

该研究通过回顾性研究与问卷测量的方法,对吸毒者的认同感、归属感与复吸风险进行了分析和探讨,并对他们的生存状况进行了初步调查,结果表明:不利的社会处境是高复吸风险的诱发因素,戒毒人员回归社会后的生存状况不容乐观;吸毒者的自我认同和社会认同程度都显著低于健康人群,社会缺乏对戒毒人员有效的社会支持;归属剥夺是导致复吸的危险性因素,戒毒人员回归社会之后缺乏亲密的人际交往和情感交流。     

特殊教育教师工作要求与职业倦怠：心理控制源的中介作用

目的：考察心理控制源在特殊教育教师工作要求与职业倦怠间的中介作用.方法：整群抽取252名特殊教育教师接受量表测量.结果：（1）工作要求与职业倦怠存在显著的性别差异;（2）相关分析表明,工作要求、职业倦怠与心理控制源之间呈显著相关;（3）心理控制源在工作要求与职业倦怠间起着中介作用;独立的中介效应检验中,三种控制源（内控性、有势力的他人、机遇）在工作要求与职业倦怠间都起着部分中介作用;综合模型中,工作要求主要通过有势力的他人这一中介与职业倦怠产生联系,同时也与职业倦怠间存在直接效应.结论：心理控制源是工作要求预测职业倦怠的部分中介因素.     

The effect of the belief in free market ideology on redressing corporate injustice

Many people in the major Western economies (e.g., United States, UK, and Germany) subscribe to free market ideology (FMI), which claims that institutional oversight of the market is unnecessary for public reaction can force corporations to regulate their own behavior. The question then becomes how people's belief in FMI affects their reactions to corporate transgressions. Given its ingroup‐centered values, we hypothesized that FMI beliefs would bias reactions to corporate transgressions. We report results of a pilot study showing that FMI beliefs are predicted by selfishness, tradition, conformity, and lack of universalism. We then report three experiments, which showed that stronger FMI beliefs predict weaker demands to redress corporate injustices committed by ingroup (but not outgroup) corporations (Studies 1–3), especially when victims of corporate wrongdoings belong to an outgroup (rather than the ingroup; Study 3). The findings inform our conceptual understanding of FMI and give insights about its implications for market justice.     

Resilience in Scientific Research: Understanding How Natural Product Research Rebounded in an Adverse Situation

The recent declining rate in the discovery of new drugs has made natural product (NP) research—the traditional method of using living organisms to acquire drug candidates—regain its importance, despite the fact that it was once regarded as an obsolete method in the face of the exalted expectations about emerging new approaches since the 1990s. The concept of ‘resilience’ in scientific research provides a clue for understanding the dynamism of this rebound in research. Four elements may be highlighted in the context of microbial NP research in Japan: first, ‘institutional precondition’ is essential in the sense that the research must be rooted in an institutional complex involving academia, drug companies, and national policies. Second, the dual nature of the ‘attack from rival innovations’ including semiotic labeling and technical advances is examined. Third, four approaches to NP research are observed as responses to such challenges: (1) reevaluating the naturalness of NPs; (2) adopting various technical elements from their rivals; (3) shifting the emphasis from the practical pursuit of drug candidates to biological research using bioprobes; and (4) examining the uneven degree of resilience between academia and industry. Fourth and finally, NPs are viewed as an icon of cultural practice. This view may eventually open the door to questions about the meaning of ‘tradition’ in the context of general contemporary scientific research.     

The Relation Between Compulsive Sexual Behaviors and Aggression in a Substance-Dependent Population

Research supports a high comorbidity between compulsive sexual behaviors (CSBs) and substance use disorders (SUDs), which are both classified by increased impulsivity. Literature has also indicated that increased impulsivity and substance use are associated with aggression. However, no known research has examined the relationship between CSBs and aggression among a substance-dependent population. The purpose of this study was to examine this relationship. Participants included 349 male patients in treatment for SUDs. Results indicated that after controlling for alcohol and drug use and problems and age, CSBs were significantly associated with total aggression, aggressive attitudes, physical aggression, and verbal aggression. This is the first known study to examine this relationship; thus continued research is needed to extend and replicate these findings.     

The power and sensitivity of four core driver workload measures for benchmarking the distraction potential of new driver vehicle interfaces

This study evaluated the power and sensitivity of several core driver workload measures in order to better understand their use as a component of future driver distraction potential evaluation procedures of the in-vehicle human machine interface (HMI). Driving is a task that requires visual, manual and cognitive resources to perform. Secondary tasks, such as mobile phone use and interaction with in-built navigation, which load onto any of these three processing resources increase driver workload and can lead to impaired driving. Because workload and distraction potential are interrelated, a comprehensive method to assess driver workload that produces valid and predictive results is needed to advance the science of distraction potential evaluation. It is also needed to incorporate into New Car Assessment Program (NCAP) testing regimes. Workload measures of cognitive (DRT [Detection Response Task] Reaction Time), visual (DRT Miss Rate), subjective (NASA-TLX [driver workload questionnaire]), and temporal demand (Task Interaction Time) were collected as participants drove one of 40 vehicles while completing a variety of secondary tasks with varying interaction requirements. Of the evaluated measures, variance and power analyses demonstrated that Task Interaction Time is the most sensitive in detecting differences in driver workload between different in-vehicle HMIs, followed by DRT Miss Rate, NASA-TLX and finally DRT Reaction Time. There were relatively weak correlations between each of the four measures. These results suggest that Task Interaction Time, coupled with a reliable visual demand metric such as DRT Miss Rate, eye glance coding, or visual occlusion, more efficiently detect differences in driver workload between different HMIs compared to DRT Reaction Time and the NASA-TLX questionnaire. These results can be used to improve the understanding of the utility of each of these core driver workload measures in assessing driver distraction potential.