Effects of delta 9-THC on marijuana smoking, dose choice, and verbal report of drug liking.

The effects of delta 9-tetrahydrocannabinol content of marijuana on cigarette smoking, dose choice, and verbal report of drug "liking" by adult males living in a residential laboratory were investigated. Marijuana cigarettes were available during programmed intervals while subjects were engaged in recreational activities. The tetrahydrocannabinol content of the cigarettes remained constant each day, but was changed across days. Subjects provided written ratings of drug liking at the end of each day. In the first study, placebo or active (2.3% delta 9-tetrahydrocannabinol) marijuana cigarettes were available for 1-, 2-, or 3-day intervals at varying times of day. The number of cigarettes smoked was unrelated to tetrahydrocannabinol content, although verbal reports of drug liking were consistently higher when marijuana cigarettes containing tetrahydrocannabinol were smoked. In a second study, a choice procedure, consisting of four 3-day blocks of 2 sample days and 1 choice day, was used. On sampling days, subjects smoked cigarettes varying in tetrahydrocannabinol content (0.0, 2.0, and 3.5%, w/w); on choice days they were allowed to choose between the two previously sampled doses. The number of cigarettes was not consistently related to tetrahydrocannabinol content. Ratings of drug liking were increased when marijuana cigarettes contained tetrahydrocannabinol, but ratings of marijuana containing 2.0% and 3.5% of the compound were similar. In contrast, subjects consistently chose the 3.5% dose over either the 0.0% or 2.0% dose. Dose choice was more sensitive to tetrahydrocannabinol content than either reports of drug liking or numbers of cigarettes smoked.     

When distorted logos are recognized as original? The role of the DRM procedure in detection of immediate and delayed consumers’ errors

IntroductionTo deal effectively with the market, one must create a distinct logo from competing logos. However, it is not uncommon that similarities between logos of various companies are enough to mislead consumers. This paper shows how the DRM paradigm as well as prototype theories can be used to investigate correct and erroneous recognitions of distorted familiar and unfamiliar logos in short- and long-term memory.MethodThe modified hybrid DRM procedure was adopted to test brand images that were distorted but perceptually similar. Participants performed the experimental task in which short- and long-term memory for logos were tested.ResultsThe results demonstrated no difference in memory performance between familiar and unfamiliar logos after a short delay. However, a discrepancy between recognizing both types of logos arose in long term memroy toward more errors for familiar images.ConclusionsThe results confirm that the DRM procedure can be successfully used by marketers as a potential tool in either detecting unfair competition or launching new brands.     

Helping behaviour among people who use drugs: Altruism and mutual aid in a harm reduction program

People who use drugs, and particularly people experiencing addiction, are rarely afforded the opportunity to have their voices heard when it comes to drug treatment or drug policy or even when attempting to define themselves and their life experiences. Of course, there is much more to a person than one area of their behaviour. The current study seeks to capture and understand the lived experiences of people who use drugs, with a focus on their relationships and helping behaviour. We interviewed 32 participants in a harm reduction program seeking to provide understanding beyond stigmatizing and criminalizing drug narratives, by exploring their motivation and context for helping behaviours. Grounded theory methodology was used to understand the patterns of helping behaviour, along with the contexts in which help is or is not given. We particularly focus on participants' distribution of syringes and carrying medicine to reverse overdose (naloxone). Participants shared stories of altruism and mutual aid, along with barriers and disincentives to helping others. We situate these behaviours within contrasting environments of a free harm reduction program and the competitive market system of the U.S. society. Implications for practice and public policy are discussed.     

Adolescent gambling and drug use

In this study, 4516 adolescents (aged 11–16 years) completed a questionnaire examining the relationship between underage National Lottery gambling, underage scratchcard gambling, cigarette smoking, drinking alcohol and drug use. It was found that these behaviours were closely linked. Adolescent gamblers reported that they were significantly more likely to drink alcohol (particularly ‘alcopops’), smoke tobacco and take drugs compared to non-gamblers. © 1998 John Wiley & Sons, Ltd.     

Assessing unit-price related remifentanil choice in rhesus monkeys

Given a commodity available at different prices, a unit-price account of choice predicts preference for the cheaper alternative. This experiment determined if rhesus monkeys preferred remifentanil (an ultra-short-acting micro-opioid agonist) delivered at a lower unit price over a higher-priced remifentanil alternative (Phases 1 and 3). Choice between equal-priced alternatives also was assessed (Phase 2). A discrete-trials procedure was arranged in which three monkeys chose between two remifentanil alternatives by responding on one of two levers. Different prices were arranged by manipulating drug dose (0.3 and 0.1 microg/kg/injection) and/or the ratio requirement. Monkeys usually chose the larger-dose alternative even when it was more expensive. Only when unit prices were relatively high (e.g., large response requirements) did monkeys choose the cheaper (or equally priced) smaller-dose alternative. Employing larger doses (0.9 and 0.3 microg/kg/injection) attenuated the larger-dose preference. The results demonstrate that choice was not determined simply by unit price. An alternative model that employs demand-function analysis to generate choice predictions is proposed.     

哮喘控制稳定后如何减停糖皮质激素

糖皮质激素是最有效的抗气道炎症药物,吸入糖皮质激素(ICS)是首选哮喘控制药物。由于治疗后达到哮喘临床控制(症状、肺功能)需要一定时间,ICS达到一定剂量后量效曲线较平坦,而全身不良反应却逐渐增加。因此,达到临床控制后在长期监测下至少维持哮喘控制3个月以上,开始减少50%ICS剂量,直至ICS减至最低维持剂量。如为ICS加另一种控制药(长效β2受体激动剂、白三烯调节剂、缓释茶碱)联合治疗达到控制者,在ICS减至最低剂量时再停用另一种控制药。应用最低剂量ICS维持控制达1年方可考虑停药。     

ESBLs大肠埃希菌Ⅰ类整合子与耐药性关系

整合子通过位点特异的基因重组在临床细菌耐药性传播中起重要作用。根据整合酶基因intⅠ的序列不同将整合子划分成4种类型,其中第一类整合子最常见,决定着细菌的多重耐药。产ESBLs菌株在整合予水平转移的介导下能增加捕获这些基因盒的可能性,更有利于耐药基因的传递和扩散。     

吸毒者回归社会的过程:归属与认同的剥夺

该研究通过回顾性研究与问卷测量的方法,对吸毒者的认同感、归属感与复吸风险进行了分析和探讨,并对他们的生存状况进行了初步调查,结果表明:不利的社会处境是高复吸风险的诱发因素,戒毒人员回归社会后的生存状况不容乐观;吸毒者的自我认同和社会认同程度都显著低于健康人群,社会缺乏对戒毒人员有效的社会支持;归属剥夺是导致复吸的危险性因素,戒毒人员回归社会之后缺乏亲密的人际交往和情感交流。     

道家去火毒法在《圣济总录》矿物类药炮制中的转变与利用

道家去火毒法源于道教炼丹术,是去除矿物类药火毒的特殊炮制方法。《圣济总录》部分继承和发展了道家去火毒方法,使矿物类药去火毒法成为《圣济总录》的一大特色。整理归纳《圣济总录》中的矿物类药去火毒法,对书中的方法深层次剖析,进一步阐释道家去火毒法在矿物类药炮制中发挥的具体作用;同时,深入挖掘生熟辅料、药衬、炮制装置以及特殊服法对矿物类药炮制去火毒的作用。《圣济总录》继承了道家去火毒法并进行改进,其去火毒法对现代矿物类药的炮制方法具有指导与启发意义。