A REVIEW OF COCAINE ABUSE: BEHAVIOR,PHARMACOLOGY, AND CLINICAL APPLICATIONS,EDITED BY S. T. HIGGINS AND J. L. KATZ

This book comprises 17 chapters that deal with a variety of topics related to cocaine and its abuse. Several of the chapters are excellent, and the book in its totality contains a wealth of information. These are major strengths. On the down side, some important topics are ignored, the relevance of several chapters to cocaine abuse is not apparent, and the various chapters are not well integrated. We recommend Cocaine Abuse as a reference volume for scientists with specific training in the areas that it covers. But we do not recommend it for cover‐to‐cover reading as an overview of cocaine abuse.     

Modulation of Taste Aversions by a Pentobarbital Drug State: An Assessment of Its Transfer Properties

In a drug-discrimination procedure using conditioned taste aversions, a pentobarbital injection signaled a taste–toxin pairing while the vehicle injection signaled the same taste in the absence of the toxin. In transfer tests, drug states transferred control over consumption to other targets. If the training target was a fluid (saccharin), then transfer occurred to other fluids (both novel and familiar) but not to solid food. If the training target was food, then some transfer occurred to novel targets (both fluids and solid food) but not to familiar targets. Control rats revealed that the differential consumption seen during acquisition and during transfer tests was not due to the summation of two simple associations (i.e., drug–toxin and flavor–toxin) but rather reflected conditional control over consumption by the drug state.     

Clients in Treatment for Alcohol Problems: Treatment Experiencesand Outcomes

This report presents an analysis of National Treatment Improvement Evaluation Study data describing the characteristics and treatment experiences of clients entering treatment for alcohol problems. Three client groups were contrasted—those entering treatment for alcohol only, for alcohol plus other drugs, or for other drugs only. Clients using alcohol only were more often white, male, and currently employed. Alcohol only clients were treated predominantly in outpatient settings. Alcohol only clients were frequently referred to treatment by the criminal justice system, and less often self-referred. In all 3 study groups, employment, general health, and mental health outcomes were improved following treatment. Illicit drug use increased marginally for the alcohol only group following treatment. No significant posttreatment reductions in reports of total abstinencefrom alcohol were found for any of the groups. Findings are discussed as they relate to research, treatment practice, and policyareas.     

Treatment Populations,Services, and Outcomes for Cocaine and Crack-Cocaine Dependence

This paper analyzes demographic and other pretreatment characteristics, measures of treatment services received, and treatment outcomes of participantsin the National Treatment Improvement Evaluation Study (NTIES), a large-scale longitudinal study of substance abuse treatment (D. R. Gerstein et al., 1997; R. A. Johnson & D. R. Gerstein, 2000). The focus here is those treated primarily for cocaine powder or crack-cocaine dependence, compared with those in treatment for other substances, particularly heroin. Crack-dependent users tend to be female and black, older than primary marijuana or alcohol users but younger than those in treatment for heroin. Primary cocaine powder or crack users are likely to have entered treatment under pressure from the criminal justice system. After treatment there are substantial reductions in use of cocaine powder and crack, especially among participants with fewer prior treatment episodes and lower pretreatment intensity of use. Longer duration and intensity of treatment result in greater reductions in cocaine and crack use.     

重症溃疡性结肠炎药物治疗的进展与困惑

目前临床上对重症溃疡性结肠炎患者的治疗多采用糖皮质激素、免疫抑制剂、生物制剂和抗生素等,使病情得到缓解。然而,这些药物的长期疗效、副作用等需要进一步临床观察,根据病情合理选择有效药物治疗。     

exploring drug users' illness representations of hiv,hepatitis b and hepatitis c using repertory grids

Abstract

Hepatitis B and C viruses are more prevalent among injecting drug users than HIV. This study explored drug users' illness representations of hepatitis B and C using repertory grid methodology. Initially, nine drug users were presented with six elements including hepatitis B and C, and HIV. Constructs were elicited via the sequential form variation of the method of triads. Elements were rated on elicited constructs using a five-point scale, and analyzed using “Flexigrid”. In a second quantitative research stage, 52 drug users were presented with six elements and supplied constructs. Results of the first stage indicated participants were able to generate constructs relating to Leventhal et al.'s (1980) features of illness representations. Most constructs, however, were causal in nature. Participants perceived hepatitis B, C and HIV similarly along the causal component. This similarity on the causal component was largely replicated in the second research stage. Participants, however, distinguished HIV from hepatitis B and C along serious, cure and timeline features. Participants did not distinguish hepatitis B from hepatitis C. The implications of these results for health promotion are discussed.     

特殊人群结核病的流行病学调查

为了了解某监狱犯人中结核病的患病及结核菌耐药情况,为防治提供依据,采用痰检和结核菌素试验的方式对研究对象进行普查,结核分枝杆菌采用罗氏培养,药敏试验采用比例法。结果显示,PPD试验总阳性率为60．54％。痰检发现24例患者,涂阳患病率为898．54／10万。培养菌株总耐药率为95．83％,其中初治耐药率、复治耐药率和多重耐药率分别为87．5％,100％和73．91％。提示该特殊人群结核病患病率高于一般人群。     

冠心病理想治疗方式的选择

冠心病的治疗包括针对高危因素病因和临床并发症的综合治疗。其中,药物治疗主要包括：抗凝／抗血小板、控制血压和调脂等。血管重建术主要包括：介入、搭桥、“杂交”手术和分子生物学治疗。药物治疗是冠心病各种治疗方法的基础,而血管重建术是现代治疗冠心病的重要手段。如何合理地选择治疗方案是临床医师面临的重要课题。     

从生态自然观看细菌的耐药

伴随抗菌药物强大的抗感染疗效的同时,细菌等病原体对抗菌药物的耐药性问题日渐显露出来。运用生态自然观辨证地对细菌进行剖析,旨在突破传统思维认识细菌耐药性产生本质,从而更加有效,更加科学地控制细菌耐药的发生。