复发性阿弗他溃疡的发生与人类疱疹病毒的潜伏

复发性阿弗他溃疡（RAU）是口腔常见病,至今病因不明,治疗效果不佳,降低患者生存质量。本文对近17年复发性阿弗他溃疡与人类疱疹病毒的相关研究结果进行分析解剖,推测β型疱疹病毒的潜伏与复制的过程可能是RAU的重要发病机制之一。     

没听到？“听”到！——来自听觉表象神经机制研究的证据

近年来听觉表象开始得到关注,相关研究包括言语声音、音乐声音、环境声音的听觉表象三类。本文梳理了认知神经科学领域对上述三种听觉表象所激活的脑区研究,比较了听觉表象和听觉对应脑区的异同,并展望了听觉表象未来的研究方向。     

从个体关系的角度看文化对社会脑功能的塑造

摘 要 尽管社会认知的内容丰富多样,但其核心在于人们对“自我”、“他人”及两者关系的理解。文化作为一种独特的社会现象,对社会认知有着广泛影响,这一点集中体现在文化对“自我” 与“他人” 信息加工及其大脑机制的影响上。文化神经科学的研究表明：文化显著影响自我相关记忆、自我表征、自我觉知等自我认知过程。这可能主要来源于不同文化人群自我建构方式的不同。上述差异的神经机制主要体现为不同文化人群自我相关加工时,其内侧前额叶功能性变化的不同。与此相对应的是,文化同样显著影响人们对他人,尤其是对他人情绪的认知。这一点集中表现为表情认知的文化优势效应及共情过程的文化差异。在神经机制上这一差异主要体现为杏仁核功能的文化可塑性。文化神经科学的未来研究,可继续探讨主流文化、区域文化、宗教文化等各种形式的文化差异：1）对自我认知与情绪认知相互作用的影响与神经基础;2）对共情（empathy）、社会比较（social comparison）、心理理论（theory of mind）与协同行为（joint action）等多种社会认知过程的影响及其神经机制。 关键词 自我建构 文化神经科学 情绪认知 自我表征 共情     

外在奖赏对陈述性记忆的影响

学习和记忆是个体赖以生存和发展的前提,如何取得好的学习和记忆效果是心理学和神经科学关注的重点。近年来,许多研究揭示奖赏可以促进记忆效果,奖赏对记忆的影响逐渐成为心理学和神经科学的热点研究课题。大脑的中脑多巴胺奖赏系统与海马记忆系统在结构和功能上均有关联。奖赏通过编码和巩固阶段以不同机制对记忆效果产生作用：在记忆编码阶段,奖赏会激活奖赏系统、注意控制系统,将更多认知资源分配给奖赏相关信息,从而促进奖赏信息的记忆效果;在记忆巩固阶段,奖赏会促进多巴胺释放,作用于海马对奖赏相关信息的加工,从而促进奖赏信息的记忆效果。未来研究可以关注奖赏对行为影响的复杂模式和内在奖赏对学习记忆的影响等方面。     

Using time‐lagged panel data analysis to study mechanisms of change in psychotherapy research: Methodological recommendations

The introduction of novel methodologies in the past decade has advanced research on mechanisms of change in observational studies. Time‐lagged panel models allow us to track session‐by‐session changes and focus on within‐patient associations between predictors and outcomes. This shift is crucial as change in mechanisms inherently takes place at a within‐patient level. These models also enable preliminary casual inferences, which can guide the development of effective personalised interventions that target mechanisms of change, used at specific treatment phases for optimal effect. Given their complexity, panel models need to be implemented with caution, as different modelling choices can significantly affect results and reduce replicability. We outline three central methodological recommendations for use of time‐lagged panel analysis to study mechanisms of change: (a) taking patient‐specific effects into account, separating out stable between‐person differences from within‐person fluctuations over time; (b) properly controlling for autoregressive effects; and (c) considering long‐term time trends. We demonstrate these recommendations in an applied example examining the session‐by‐session alliance–outcome association in a naturalistic psychotherapy study. We present limitations of time‐lagged panel analysis and future directions.     

催产素对产后抑郁症患者母性行为的调节作用

产后抑郁症是指女性分娩后一段时间内出现的严重抑郁发作现象。研究表明, 催产素不仅参与分娩过程和正常的母性行为表达, 也在调节产后抑郁的发病及患者的母性行为中起到了重要的作用。产后抑郁症患者的情绪和认知功能受损, 这可能导致了母性行为表达质量的下降; 催产素可以通过中脑边缘多巴胺系统来调控母性行为, 作用于内侧视前区(MPOA)来激活中脑腹侧被盖区(VTA)-伏隔核(NAc)环路从而影响伏隔核内多巴胺的分泌; 催产素对产后抑郁症中母性行为的调节机制可能是通过调节五羟色胺系统的功能来发挥抗焦虑作用, 也可能是通过与其它激素的交互作用来加速母性行为的表达。未来研究进一步明确催产素在中枢神经环路中的功能差异, 以及社会支持对产后抑郁症患者催产素的使用带来的影响。     

Who speaks? Who looks? Who feels? Point of view in autobiographical narratives1

In this paper, the author aims to substantiate Freud's claim that neurotic illness creates gaps in autobiographical narratives in terms of the narrator's stating and inducing perspectives. He sketches out the role of narrative perspective and the joint taking of a shared perspective by analyst and patient in psychoanalytic therapy. He introduces four ways of representing perspectives in narratives. Three degrees of narrative distortion are exemplifi ed by three excerpts from life narratives and explored in terms of narrative perspective representation. The most comprehensive perspective representation is achieved in the fi rst example by explicitly stating the present perspective of the narrator as well as the past perspective of the story's protagonist by use of mental verbs. In the second narrative, exclusive use of linguistic forms for inducing the protagonist's perspective both overwhelms the narrator and gives the listener an incomplete picture of what happened. Inconsistent motives, denial of responsibility and omission of detail render the third narrative even more diffi cult to follow. The author discusses the clinical signifi cance of this exploratory analysis of perspectives in narratives in terms of claiming responsibility for one's past action and of level of defence mechanisms, and by highlighting the emotional impact on listeners, which the author suggests is the stronger the more perspectives are left out. He discusses analogies to countertransference. The analysis of narrative perspectives offers an approach for systematic research in psychoanalytic practice.     

Processes and pathways in development via digital media: Examples from word learning

Word learning unfolds over multiple, cascading pathways which support in-the-moment processing and learning. The process is refined with each exposure to a word, and exposures to new words occur across a variety of forms and contexts. However, as children are exposed to more and more digital media, the ways in which children encounter, learn, and build on their vocabulary is also shifting. These shifts represent changes in context, content, and at the level of the child that can lead to negative outcomes. Less work, however, has discussed what these differences mean for how things change in the underlying developmental cascade and learning processes. Here, we suggest that the increasing presence of digital media may shift the developmental pathways for learning (the chain of events that support future learning) but not necessarily the developmental processes (the mechanisms underlying learning). Moreover, the interaction of the two may lead to different behavior and outcomes for learning in a digital era. We argue it is imperative for researchers to not only study how digital media differs from everyday learning, but directly measure if the well-worn pathways, processes, and variables found with decades of research with real items translate to a digital media era.     

Microstructures and strengthening mechanisms in high-carbon titanium-microalloyed interstitial-free steels

We report the mechanical properties and microstructures of titanium-microalloyed interstitial-free (IF) steels with different carbon contents smelted and rolled in the laboratory. The results show an increase of yield strength and tensile strength with carbon content, which are enhanced with lower coiling temperature (CT). Microstructure analysis reveals that the ferrite grain size varies from 11 to 23?μm, while the average size of TiC as the main second-phase particle ranges from 10 to 35?nm. The sample with 80?ppm carbon and 853?K CT reaches a mechanical strength close to that of high-strength IF steels. The increase of yield strength is mainly attributed to both grain-refining and precipitation strengthening.