Aspirations,Attainments, and Satisfaction: Life Cycle Differences Between American Women and Men

Aspirations, along with attainments, play an important role in shaping well-being. Early in adult life women are more likely than men to fulfill their material goods and family life aspirations; their satisfaction in these domains is correspondingly higher; and so too is their overall happiness. Material goods aspirations refer here to desires for a number of big-ticket consumer goods, such as a home, car, travel abroad and vacation home. In later life these gender differences turn around. Men come closer than women to fulfilling their material goods and family life aspirations, are more satisfied with their financial situation and family life, and are the happier of the two genders. An important factor underlying the turnaround in fulfillment of aspirations for material goods and family life is probably the shift over the course of the life cycle in the relative proportion of women and men in marital and non-marital unions.     

Forum: Crafting the Introductory Course in Religious Studies

This series of short essays considers the complex choices and decision‐making processes of instructors preparing to teach, and continuing to teach, introductory courses in religious studies. In a paper originally presented in the University of Chicago's “The Craft of Teaching in the Academic Study of Religion” series, Russell McCutcheon explores a “baker's dozen” of such choices and the larger pedagogical problems with which they are entwined, ranging from classic questions of skill development and content coverage to philosophical concerns around students' identification with their topics of study and institutional concerns around governance and assessment. Aaron Hollander provides a brief introduction and four doctoral students at the University of Chicago Divinity School respond to McCutcheon's essay, widening its scope, testing its applicability, and interrogating its undergirding suppositions from the perspective of early‐career educators in the field.     

阅读中的快速启动范式述评

快速启动范式（Sereno & Rayner, 1992）是一种基于呈现随眼动变化技术而设计的眼动范式,主要用于研究中央凹视野内字词识别的瞬时启动,通过精确控制启动条件和启动时窗,以考察词汇通达过程中词汇水平（如,词频、词长等）、亚词汇水平（如,语音、语义、字形等）信息的加工时序。本文从基本原理、设计基础、应用领域、注意事项等方面对快速启动范式进行了较为深入的解读和介绍,并结合已有的研究成果,指出了该范式在汉语阅读中的应用价值。     

Presurgical Coping, Depression, and Quality of Life in Persons with Parkinson's Disease

This study describes utilization of coping strategies and evaluates the interaction between coping strategies, depression, and quality of life (QOL) in patients with Parkinson's disease (PD) who are being considered for neurosurgical intervention. Eighty patients (mean age 61.7 years) with PD being evaluated for possible deep brain stimulation completed self-report instruments of coping strategies (Coping Responses Inventory), depression (Beck Depression Inventory), and disease-specific QOL (Parkinson's Disease Questionnaire-39). Analyses showed that patients with PD cope with the acute stressor of approaching neurosurgery through a variety of strategies, but particularly avoidant and behavioral strategies. When the correlated but apparently opposing effects of cognitive and behavioral strategies were teased apart, greater use of cognitive strategies was associated with more severe depressive symptomatology (and poorer QOL), while greater use of behavioral strategies appeared to be associated with less depression. Depressive symptomatology, in turn, was associated with poorer QOL. However, coping had minimal direct association with QOL. From this it was concluded that patients with advanced PD generate a variety of coping responses to an acute stressor such as surgery, and the use of behavioral strategies, in particular seeking of alternative enjoyable activities, may be associated with better mood if salutary effects are not overwhelmed by less helpful cognitive coping techniques. The minimization of depressive symptomatology, in turn, is associated with better QOL.     

The value of stress-management interventions in life-threatening medical conditions

Emotional stress has been associated with the development and progression of several chronic medical conditions. Recently, researchers have assessed the impact of stress-management interventions on patients' psychological functioning, quality of life, and various disease outcomes, including survival. This review summarizes the value of stress-management techniques in the treatment of two important, life-threatening conditions: coronary heart disease and cancer. Results from randomized clinical trials indicate that psychological interventions can improve patients' psychological functioning and quality of life. However, there is limited evidence to suggest that these interventions significantly reduce morbidity and mortality.     

The clinical utility of the auditory P300 latency subcomponent event-related potential in preclinical diagnosis of patients with mild cognitive impairment and Alzheimer’s disease

The present meta-analysis investigated the clinical utility of the auditory P300 latency event-related potential in differentiating patients with Alzheimer’s disease (AD), patients with mild cognitive impairment (MCI), and unaffected controls. Effect size estimates were computed from mean P300 latency measurements at midline electrodes between patients and unaffected controls using the random effects restricted maximum likelihood model. The effects of clinical and ERP/EEG methological variables were assessed in a moderator analysis. P300 latency was found to be significantly prolonged in patients with AD (and MCI) compared to unaffected controls. Shortened P300 latencies were observed when comparing patients with MCI to patients with AD. Clinically relevant differences in P300 latency effect sizes were associated with mean age, interstimulus interval, stimulus difference, target frequency, reference electrode, and sampling rate. The meta-analytic findings provide robust statistical evidence for the use of the auditory P300 latency subcomponent as a biological marker of prodromal AD.     

Evidence of Impaired Glucose Tolerance and Insulin Resistance in Patients With Alzheimer’s Disease

Alzheimer’s disease (AD) and diabetes rarely occur together, a finding that provides a possible clue as to the development of AD. Abnormal glucose metabolism is not limited to diabetes, but also can include impaired glucose tolerance, insulin resistance, and hyperinsulinemia. AD patients have significantly varying insulin levels after drinking sugared sodas and thus may be classified as insulin resistant. After reviewing the literature on impaired glucose tolerance and insulin production in AD, we present several hypotheses as possible explanations for the relationship between insulin resistance and AD. Finally, we suggest future studies, including studies on use of thiazolidinediones (currently used in the treatment of diabetes) in AD.     

Parkinsonian Patients Reduce Their Stroke Size with Increased Processing Demands

Parkinson's disease (PD) patients often show reductions in writing size (micrographia) as the length of the text they produce increases. The cause for these reductions in stroke size are not well understood. Reductions in stroke size could be associated with either concurrent processing demands that result from the coordination and control of fingers, wrist, and arm during writing and the processing of future words or increased extension of the wrist joint as the execution of the writing progresses to the right across the page, resulting in increased stiffness in the pen-limb system. Parkinson's patients and elderly controls wrote phrases of different lengths with target patterns in various serial positions. When the number of words to be written increased, PD patients reduced their stroke size of the initial target pattern, while the elderly controls did not reduce their stroke size. There was no systematic change in stroke size of the second pattern as function of serial position. This result suggests that PD patients reduce the size of their handwriting strokes when concurrent processing load increases.     

异体造血干细胞移植问题、发展与思考

异体造血干细胞移植(Allo-HSCT)已成为治疗恶性血液病及其他各种疾病的有效方法之一。在Allo-HSCT中由于供体和受体免疫屏障的存在。从而一开始就是一个供受体矛盾的对立统一的过程。对其中矛盾的研究和解决充满了辩证唯物的哲学思想。也促使Allo-HSCT技术不断发展。新的方法和理念不断出现。使Allo-HSCT治疗白血病的疗效不断提高。     

“自杀”：一个重要的伦理问题

自杀现已成为人类死亡十大原因之一 ,而且呈现出低龄化的趋势 ,越来越引起社会的关注。因而 ,从政治、经济、社会、疾病、文化等多视角来寻找自杀的外部原因 ,对探究这个重要的伦理问题是有益的。