左侧眶额皮层在自动情绪调节下注意选择中的作用：来自经颅直流电刺激的证据

前人研究表明自动情绪调节能够自上而下地影响情绪及情绪性注意过程。近来有研究提示自动情绪调节与眶额皮层(orbitofrontal cortex, OFC)有关。也有研究表明左侧OFC的激活影响负性注意偏向。本研究采用经颅直流电刺激技术,考察阈下启动情绪控制目标条件下,抑制左侧眶额皮层兴奋性是否影响负性注意偏向。结果发现,使用阴极刺激抑制左侧OFC活动可以加快被试对与恐惧刺激位置一致的探测点的反应。该结果提示左侧眶额皮层是自动情绪调节下情绪性注意选择相关的重要脑区。     

21世纪我国消化病学发展战略的若干思考

就21世纪消化病的研究与发展的方向和展望,从宏观调控与哲学思想方面提出了如下几个措施;预防为主,人文社会为本;加强基础研究,充分利用科技成果;突出重点,循序渐进;促进中西医结合,充分利用和研究中医药的临床疗效;重视人才培养,提高梯队素质。     

基于项目区分度的双目标CD-CAT选题策略

针对双目标CD-CAT,将六种项目区分度（鉴别力D、一般区分度GDI、优势比OR、2PL的区分度a、属性区分度ADI、认知诊断区分度CDI）分别与IPA方法结合,得到新的选题策略。模拟研究比较了它们的表现,还考察了区分度分层在控制项目曝光的表现。结果发现：新方法都能明显提高知识状态的判准率和能力估计精度;分层选题均能很好地提高题库利用率。总体上,OR加权能显著提高测量精度;OR分层选题在保证测量精度条件下显著提高项目曝光均匀性。     

晚清民国癌症概念的翻译及流变

1805年以降,一大批西医概念“旅行”至我国,其中不乏全新概念,如cancer概念。中医自古便有“癰”“疽”“癰疽”等概念,它们以译词的形式参与到西医“癌症”知识最初在我国的传播,致使20世纪初,cancer概念同carbuncle概念的混淆。国人对“癌症”概念的容受随“癌”一名之确立发生于20世纪30年代前后,对其认知也随相关知识系统性传入、孙中山先生因癌病逝消息的蔓延及“癌”字隐喻用法的形成而愈发清晰。“癌”字最终的采纳则同时受日语新词大量导入及制度化因素的影响。通过考察西医“癌症”概念在我国的翻译及流变,得以管窥西医入华史一角。

     

临床研究结果发布的伦理审查辨析

《涉及人的生命科学和医学研究伦理审查办法》对于临床研究结果的发布提出了伦理审查和知情同意告知的要求。探讨临床研究的结果发布可以最大程度实现临床研究的价值,包括有利于实现临床研究的透明性,有利于增强公众的信赖,有利于落实研究参与者的知情权,并分析了研究结果发布在隐私保护、发布形式、发布时间、科研诚信和学术不端方面带来的潜在伦理问题。建议伦理委员会从隐私风险最小化、发布形式规范化、发布时间合理化三方面进行伦理审查,同时给出了加强多部门协作和跟踪审查以及参与学术不端治理的伦理审查策略建议。

     

媒体多任务的效用：听觉信息干扰和视听信息整合的实验证据

采用心理旋转范式和词汇判断范式,探讨媒体多任务经验不同者在听觉信息干扰和视听信息整合情境下对图形一致性和真假词的判断表现。结果发现：（1）以判断图形一致性为实验任务,在无声和低音干扰条件下,低经验组的正确率均显著高于高经验组,两组的反应时差异均不显著;在高音干扰条件下,高经验组的反应时显著短于低经验组,正确率则没有显著差异。（2）以真假词判断为实验任务,对真词进行判断,在三种听觉条件下,高经验组在语音匹配条件下的反应时最短,与低经验组无显著差异,但正确率显著高于低经验组,与另两种听觉条件没有显著差异;低经验组在语音匹配条件下的反应时显著长于另两种听觉条件,正确率则显著高于无声条件,与不匹配条件差异不显著。对假词的判断,低经验组在三种听觉条件下的反应时均显著短于高经验组,正确率与高经验组均无显著差异。研究表明,媒体多任务经验丰富者相比经验缺乏者受到任务无关的纯短高音干扰的影响要小,在需要视听通道语义整合的加工中具有一定的优势。     

小学2～4年级儿童数学应用题表征策略差异的研究

本研究运用实验法和临床访谈法对某普通小学的123名2～4年级学生进行了数学应用题测验,以考察数学学优生和学差生在解决比较应用题时表征策略的差异。结果表明:(1)从2～4年级儿童解答一致和不一致应用题上看,学优生较多地使用问题模型策略对问题进行表征,学差生较多地使用直接转换策略对问题进行表征;(2)除学差女生的解题正确率低于学差男生的正确率,学差女生自我报告中直接转换策略的使用多于学差男生外,在其它方面,性别差异并不显著;(3)随着年级的升高,学优生在使用问题模型策略上越来越成熟,学差生并没有学会使用更加有效的问题模型表征策略,仍然停留在直接转换策略上,但他们在关于策略使用的认识上有所提高。     

长期高策略性技能训练对运动员大脑白质结构的影响：一项DTI研究

目前关于运动员经验优势的脑机制还存在争议, 尤其对于涉及较多认知过程参与的高策略性技能项目运动员, 其大脑白质结构可塑性变化还需进一步探究。研究横向对比了乒乓球运动员和非运动员大脑白质纤维束的弥散张量成像数据。结果发现, 相比于非运动员, 乒乓球运动员在连接背侧和腹侧通路脑区的双侧皮质脊髓束、左侧上纵束、左侧下纵束和双侧额枕下束的各向异性值(FA)更大, 进一步分析发现, 部分腹侧通路白质纤维束FA增加的原因是径向扩散系数(RD)下降。研究结果支持了动作双通路模型。提示经过长期高策略性技能训练, 乒乓球运动员在背侧和腹侧通路上的白质纤维束结构完整性增强。     

Effectiveness of the compensatory strategy adopted by older drivers: Difference between professional and non-professional drivers

It has been a controversial issue for the effect of ageing population on driving safety. Apparently, drivers’ physiological and cognitive performances deteriorate with age. However, older drivers may compensate for the elevated risk by adjusting their behaviors, known as compensatory strategy. Despite the extensive research on this topic, the compensatory strategy of older professional drivers is not well understood since many studies focused on the differences in compensatory behavior between older and young drivers. Professional drivers tend to be more skillful and able to cope with the unfavorable driving environments, thus presenting a higher capability to mitigate the risk. This study attempts to examine the compensatory behavior and its safety effect amongst older professional drivers, as compared to those of older non-professional drivers, using the driving simulator approach. In the driving simulator experiment, participants were asked to follow a leading vehicle for one hour, and two sudden brake events were presented. 41 (mid-aged and older) drivers completed the driving tests. Each participant was required to complete a car-following test, either under high or low traffic flow conditions. Performance indicators include driving capability (i.e. lateral control, longitudinal control, and brake reaction time) and compensatory behavior (i.e. average speed, and time headway). Additionally, two modified traffic conflict measures: time exposed time-to-collision (TET) and time integrated time-to-collision (TIT) are applied to indicate the traffic conflict risk. The random parameter Tobit models were estimated to measure the association between conflict risk and driver attributes, and random intercept models were used to assess other driving performance indicators. Results show that despite the impaired lateral control performance and longer brake reaction time of older drivers, the likelihood of severe traffic conflict of older drivers is lower than that of mid-aged drivers. Furthermore, though both older professional and older non-professional drivers adopted longer time headway, the reduction in the risk of severe traffic conflict is more profound among the older professional drivers. Such findings suggest that older professional drivers are more capable of mitigating the possible collision risk by adopting the compensatory strategy, as compared to older non-professional drivers. This justifies the existence of compound effect by the compensatory strategy of older driver and better driving skills of professional driver. This research provides useful insights into driver training and management strategies for employers, as older drivers would become a major cohort in the transportation industry.