成瘾药物心理依赖及复发的脑机制研究

围绕学习、记忆、情绪及应激等心理因素与复发的关系,应用阿片类物质心理依赖研究条件性位置偏爱,条件性位置厌恶,Morris水迷宫量化觅药动机模型,行为及条件性行为敏感化等多种动物行为模型,从情绪相关学习、记忆在成瘾行为中的作用,不同神经核团与神经递质系统活动性的改变,应激相关因素易化的成瘾易感性,自然奖赏与成瘾药物奖赏相关记忆的比较研究等方面,对应激与记忆相关的吗啡心理依赖及复发的脑机制进行了系列研究     

Boring Infinite Descent

In formal ontology, infinite regresses are generally considered a bad sign. One debate where such regresses come into play is the debate about fundamentality. Arguments in favour of some type of fundamentalism are many, but they generally share the idea that infinite chains of ontological dependence must be ruled out. Some motivations for this view are assessed in this article, with the conclusion that such infinite chains may not always be vicious. Indeed, there may even be room for a type of fundamentalism combined with infinite descent as long as this descent is “boring,” that is, the same structure repeats ad infinitum. A start is made in the article towards a systematic account of this type of infinite descent. The philosophical prospects and scientific tenability of the account are briefly evaluated using an example from physics.     

Conceptualising Decadent Technology: A Case Study of Path Dependence in Radiotherapy

Abstract

Large-scale investments in health technologies often have limited evidence for effectiveness when first introduced. Nevertheless, professional and public discourses often present the advantages of such investments, with unknown risks, as necessary and entailing significant improvement. Such discourses are evident with the introduction of the Linac Adapted Conebeam Imager (LACI), introduced to improve the accuracy of radiotherapy treatments. From one perspective, the introduction of such technologies can be considered to be decadent since there is limited, if any, evidence of improvement of current standards and procedures, yet they are promoted as the latest and best technologies for solving societal problems. Connecting the concepts of decadence to those of path dependence, through the case of the LACI, enables the exploration of the ‘technical interrelatedness’ of technological changes. Building on the concept of path dependence, it is possible to demonstrate how introducing a closely related technology does not only become a low-risk course of action. Rather change is demanded (but not determined) as well as potential alternative systems being obscured. With decadent technologies, any future changes are not only dependent upon past introductions; but also they create a need for future changes. Such a view demonstrates how these technologies may not necessarily offer any improvements, but rather contribute to the creation of ongoing demand for unproven technologies. As a result they may encourage the introduction of increasingly complex technologies.     

基于易感人格的药物成瘾者工作记忆对执行控制功能的调节作用

为了解工作记忆在易感性人格对药物成瘾者执行控制功能和抑制性影响过程中的调节作用,采用BIS和SSS量袁以及连续操作测验（CPT）、2-back任务、威斯康星卡片分类任务（WCST）对150名药物成瘾者和100名年龄、性别及智商相匹配的非药物成瘾者实施冲动性人格、认知控制功能测试。结果发现在2-back任务正确率（工作记忆）高低不同的情况下,注意冲动性人格特质得分对执行控制功能会产生不同的影响。这说明工作记忆在冲动性人格对抑制性的影响中具有调节作用。     

Psychological treatment of hypnotic-dependent insomnia in a primarily older adult sample

Objective

This study tested cognitive behavior therapy (CBT) in hypnotic-dependent, late middle-age and older adults with insomnia.

Method

Seventy volunteers age 50 and older were randomized to CBT plus drug withdrawal, placebo biofeedback (PL) plus drug withdrawal, or drug withdrawal (MED) only. The CBT and PL groups received eight, 45 min weekly treatment sessions. The drug withdrawal protocol comprised slow tapering monitored with about six biweekly, 30 min sessions. Assessment including polysomnography (PSG), sleep diaries, hypnotic consumption, daytime functioning questionnaires, and drug screens collected at baseline, posttreatment, and 1-year follow-up.

Results

Only the CBT group showed significant sleep diary improvement, sleep onset latency significantly decreased at posttreatment. For all sleep diary measures for all groups, including MED, sleep trended to improvement from baseline to follow-up. Most PSG sleep variables did not significantly change. There were no significant between group differences in medication reduction. Compared to baseline, the three groups decreased hypnotic use at posttreatment, down 84%, and follow-up, down 66%. There was no evidence of withdrawal side-effects. Daytime functioning, including anxiety and depression, improved by posttreatment. Rigorous methodological features, including documentation of strong treatment implementation and the presence of a credible placebo, elevated the confidence due these findings.

Conclusions

Gradual drug withdrawal was associated with substantial hypnotic reduction at posttreatment and follow-up, and withdrawal side-effects were absent. When supplemented with CBT, participants accrued incremental self-reported, but not PSG, sleep benefits.     

Reference-dependent sympathy

Natural disasters and other traumatic events often draw a greater charitable response than do ongoing misfortunes, even those that may cause even more widespread misery, such as famine or malaria. Why is the response disproportionate to need? The notion of reference dependence critical to Prospect Theory (Kahneman & Tversky, 1979) maintains that self-utility, or benefit to self, is not absolute level of wealth but rather gain or loss relative to a reference point. Four studies show that sympathy (Study 1), dictator offers (Study 2), and judgments of deservingness (Study 3a) are reference-dependent: people respond greater to victims of loss than to victims of chronic conditions. This tendency goes away when people evaluate victims in comparison (Study 3b) and when evaluating affect-poor “statistical victims”, as compared to affect-rich “identifiable victims” (Study 4). Together, these results shed light on seemingly irrational patterns of humanitarian aid.     

To err again is human: exploring a bidirectional relationship between pressure and performance failure feedback

ABSTRACT

Background and Objectives: While the potentially negative effects of pressure on skilled performance have been well studied in laboratory-based research, theoretically driven questions based on real-world performance data are lacking.

Design: We aimed to test the predictions of the newly developed Attentional Control Theory: Sport (ACTS), using archived play-by-play data from the past seven seasons of the National Football League (American Football).

Methods: An additive scoring system was developed to characterize the degree of pressure on 212,356 individual offensive plays and a Bayesian regression model was used to test the relationship between performance, pressure and preceding negative outcomes, as outlined in ACTS.

Results: There was found to be a clear increase in the incidence of failures on high pressure plays (odds ratio?=?1.20), and on plays immediately following a previous play failure (odds ratio?=?1.09). Additionally, a combined interactive effect of previous failure and pressure indicated that the feedback effect of negative outcomes was greater when pressure was already high (odds ratio?=?1.10), in line with the predictions of ACTS.

Conclusions: These findings reveal the importance of exploring momentary changes in pressure in real-world sport settings, and the role of failure feedback in influencing the pressure-performance relationship.     

Socially Constructed Technology

The concepts of omniscience and omnipotence are defined in 2 × 2 ordinal games, and implications for the optimal play of these games, when one player is omniscient or omnipotent and the other player is aware of his omniscience or omnipotence, are derived. Intuitively, omniscience allows a player to predict the strategy choice of an opponent in advance of play, and omnipotence allows a player, after initial strategy choices are made, to continue to move after the other player is forced to stop. Omniscience and its awareness by an opponent may hurt both players, but this problem can always be rectified if the other player is omniscient. This pathology can also be rectified if at least one of the two players is omnipotent, which can override the effects of omniscience. In some games, one player's omnipotence ‐ versus the other's ‐ helps him, whereas in other games the outcome induced does not depend on which player is omnipotent. Deducing whether a player is superior (omniscient or omnipotent) from the nature of his game playing alone raises several problems, however, suggesting the difficulty of devising tests for detecting superior ability in games.     

不同认知方式个体图形一致性判断过程中的ERP研究

使用ERP技术对选取的27名右利手大学生（场独立14名,场依存13名）在图形一致性判断过程中的ERP进行分析,结果表明：1）在图形一致性的判断任务中,场依存者的前额叶与中央区在200ms之前的N85与P160峰-峰之差明显大于场独立者,在枕叶区的负波N120波幅明显高于场独立者,这说明场依存者在对图形一致性比较的视觉信息处理的早期阶段即进行了更深度的加工。2）场独立者的N290波幅高于场依存者,而N290潜伏期比场依存者明显的长,这说明场独立者在后期对图形进行了更深入的分析比对。