易感人格的工作记忆特征对药物成瘾的调节机制

药物成瘾是指持续使用成瘾药物, 出现耐受性和戒断症状并严重阻碍正常社会功能的精神疾病。工作记忆在调节药物成瘾行为中扮演了中心角色：在神经易感性和易感人格特质基础上, 低工作记忆容量导致危险决策和去抑制性, 进而影响寻求药物和复吸行为。目前的研究基于已经产生成瘾的个体, 无法区别神经易感性、人格特质以及工作记忆缺陷是药物成瘾的原因还是结果; 而且, 仅从认知角度研究药物成瘾的原因, 会忽视该行为受多个因素影响的事实。     

Assessment of Nicotine Dependence Among Substance Abusing Adolescent Smokers: A Comparison of the DSM-IV Criteria and the Modified Fagerström Tolerance Questionnaire

Nicotine dependence has been found to be a significant factor in adolescent smoking persistence. However, measures of this construct are primarily adult-derived, limiting their utility as bases for characterizing nicotine dependence and formulating youth intervention strategies. This issue is of particular importance among substance abusing youth who have substantially higher rates of cigarette smoking than do adolescents in the general population. The objectives of this preliminary study were to examine the construct validity of the DSM-IV nicotine dependence criteria and the modified Fagerström Tolerance Questionnaire (mFTQ) and to compare the DSM-IV diagnostic criteria for nicotine dependence with the mFTQ in a sample of 67 adolescent smokers in treatment for substance abuse. Results revealed that more participants were classified as nicotine dependent using DSM-IV criteria than by mFTQ scores. Little evidence was found for construct validity of these measures and convergence between the two measures was low. Findings also suggested that the present measures do not capture optimally broad dimensions of adolescent nicotine dependence.     

干扰材料的熟悉性和认知方式对语篇阅读的影响

采用熟悉词和不熟悉词为干扰材料,考察了干扰材料的熟悉性对语篇阅读的影响.实验第一阶段要求不同认知方式被试朗读插入熟悉度不同干扰材料的短文,考查被试的阅读效率;第二阶段采用学习—自由回忆任务考查不同提示条件下在短文中使用过的干扰词和新词的学习效果.结果发现:(1)对场独立者而言,熟悉词的干扰作用明显大于不熟悉词,而对场依存者而言,熟悉词和不熟悉词的干扰作用无差异;(2)在提示条件下,被试对干扰词的回忆量大于对新词的回忆量.研究结果表明,在语篇阅读过程中,与场依存者相比,熟悉的干扰材料对场独立者的影响更大;熟悉词比不熟悉词产生更大干扰的原因可能是由于其激活了读者更多的经验,而非具有加工的优势.     

经颅直流电刺激技术在物质依赖治疗中的应用

物质依赖是一种慢性、复发性脑部疾病, 给个体及社会带来极大损害。研究发现, 经颅直流电刺激(transcranial direct current stimulation, tDCS)可以通过调节背外侧前额叶(dorsolateral prefrontal cortex, DLPFC)脑区的兴奋性降低物质依赖者的渴求, 并改善受损的认知功能。tDCS具有副作用小、操作简便、费用低廉等优点, 因此在物质依赖治疗领域应用前景广泛。未来应考虑确定最佳的刺激参数及刺激位置, 同时考虑物质依赖者的种类及个体差异, 与其他疗法结合使用, 并进一步深入探索tDCS治疗物质依赖的神经机制。     

自动化信任和依赖对航空安全的危害及其改进

自动化系统在现今航空业中得到了广泛应用,然而复杂的自动化系统的引入产生了新的失误模式,使航空人因安全问题变得更加突出。受多种因素影响,操作者在与自动化系统的交互过程中并不总能达到适度的信任校准水平。非适度自动化信任和依赖引发了严重的航空安全事故。值得欣慰的是,以人为中心的自动化显示设计和训练能够将非适度自动化信任和依赖调整到适度状态。     

背景性渴求与事件性渴求:区分心理渴求对尼古丁成瘾的不同作用路径

大量研究发现心理渴求机制的紊乱是尼古丁成瘾的核心机制之一。线索暴露是探索心理渴求与尼古丁成瘾关系的重要研究范式。但最近研究者提出该范式较难区分事件性渴求与背景性渴求,导致无法清楚定位渴求在尼古丁成瘾中扮演的角色。通过对以往文献的回顾,对不同成瘾概念、作用机制和生理基础进行对比分析,认为事件性渴求与背景性渴求两者在维持成瘾行为上的确存在不同的作用路径。未来研究应改进实验范式,分别探讨两种心理渴求与尼古丁成瘾的内在联系,完善心理渴求与尼古丁成瘾的关系模型,为尼古丁成瘾的治疗和干预等方法提供一定的理论依据。     

The effect of stress on craving for methadone depends on the timing of last methadone dose

Background

This study examined the extent to which the timing of last methadone dose moderates the influence of a laboratory stressor on craving for methadone in a sample of methadone maintenance patients.

Methods

Methadone maintenance patients (N = 41) completed a computerized stress manipulation with two levels (low and high stress) on two separate days: (1) immediately following the administration of their standard daily methadone dose and (2) immediately prior to receiving their standard daily dose. The impact of stress, timing of methadone dose and their interaction were examined on self-report measures of stress and craving for methadone.

Results

Craving ratings varied according to the timing of last methadone dose. Immediately following methadone dose (i.e., day 1), there was no effect for stress on craving (0.12; p = 0.30). However, prior to receiving methadone dose (i.e., day 2), the high stress effect on craving was significant (1.51; p < 0.001).

Discussion

The present findings indicate that patients currently receiving methadone maintenance treatment may be particularly vulnerable to stress-related relapse immediately prior to daily methadone dosing.     

基于预期理论的参照依赖

参照依赖是指个体基于某一参照点对得失价值进行判断:参照点之上,个体感受为收益,反之即为损失.参照依赖现象广泛存在于生活中的各种领域.当前,对参照依赖心理机制的解释主要有预期理论、后悔理论和三阶段参照点理论.参照依赖的影响因素主要包括经验、情绪状态、文化、目标和认知对象的特点等.未来的研究应主要集中于参照依赖的产生根源,深入探讨参照依赖的神经机制,加强动态参照点、多重参照点以及群体中参照依赖现象的研究.