A comparison of trichotillomania and obsessive-compulsive disorder

The validity of conceptualizing trichotillomania (TCM) and obsessive-compulsive disorder (OCD) as separate and distinct diagnoses was examined in a study of 20 patients with each disorder. A comparison of demographic, psychometric, and clinical features between the two groups revealed a number of statistically significant differences. Patients meeting the criteria for OCD scored higher on measures of psychiatric symptomatology including ratings of obsessions and compulsions, depression, interpersonal sensitivity, general anxiety, phobic anxiety, and psychoticism. Patients meeting the criteria for TCM reported an earlier age at onset than those with OCD. Stressors associated with onset were also significantly different between groups. These results support the validity of conceptualizing TCM and OCD as differing behavioral disorders.Portions of this paper were presented at the annual meeting of the Anxiety Disorders Association of America (March 1992) in Dallas, TX, and at the annual meeting of the American Psychiatric Association (May 1992) in Washington, DC.     

A support group for couples who have terminated a pregnancy after prenatal diagnosis: Recurrent themes and observations

Genetic Counselors are increasingly becoming involved in organizing and facilitating support groups for couples who have terminated a pregnancy because of an abnormal fetal diagnosis. This paper discusses recurrent themes which have emerged in the FATE (Feelings After the Termination Experience) support group which was founded in New Jersey in 1990. By becoming familiar with the issues we have observed in our support group, genetic counselors should be better able to understand and empathize with their patients who make the decision to terminate a much wanted pregnancy. They may also feel better prepared to become involved in organizing and facilitating such support groups.     

跨通路识别汉字形音的偏差相关成分研究

采用提高非注意纯度的“跨通路延迟反应”实验范式,研究汉字形音识别的跨通路注意事件相关电位（ＥＲＰ）,以偏差刺激ＥＲＰ减去标准刺激ＥＲＰ的早期偏差相关负波（ＤＲＮ１）为主要分析对象。以１５名正常青年为被试。结果发现：无论注意与否及何种刺激,听觉Ｎ１最大峰均位于额中央部,而视觉Ｎ１最大峰位于两侧枕部与颠后部,具有明显的通路差异性。在本实验条件下,听觉与视觉通路的ＤＲＮ１与失匹配负波（ＭＭＮ）在许多性质上相似,反映着对汉字形音识别的自动加工。根据波幅及其头皮分布特点,注意条件下的Ｎ３５０很可能是Ｎ２００与Ｎ４００的重叠,并主要表现出Ｎ４００的特点;而非注意条件下的Ｎ３５０则可能是Ｎ２００。Ｎ３５０的属性因条件而异,表明ＥＲＰ成分反映的大脑加工机制具有可塑性。     

从黑夜走向黎明：动脉粥样硬化从早期发现到消退

年１０年来,动态粥样硬化的早期诊断已成为可能,影像学能无创直接检测血管功能和形态学变化。在此基础上,动态粥样硬化的防治也进入了一级预防的时代。一级预防使早期粥样硬化消退,特效降脂药也可使中、晚期粥样硬化患者明显受益。随着对动态粥样硬化发病机制认识的不断深入,到下世纪初,人类有可能终止动态粥样硬化在全球的肆虐。     

RECREATING THE SCENE: AN EFFECTIVE WAY TO PROVIDE DELAYED PUNISHMENT FOR INAPPROPRIATE MOTOR BEHAVIOR

A mediated punishment procedure that involved recreating a behavioral sequence by guiding the subject through the behavior in the situation in which it occurred was used to suppress several severe problem behaviors in two developmentally delayed children. The mediational procedure was first used with a 4-year-old autistic boy for biting and then for foot stomping. Next the procedure was used for stealing and hoarding behavior with a multiply handicapped 17-year-old girl. Results indicated that the procedure was effective and produced relatively rapid results. One advantage of the procedure is that it provides an opportunity for trained personnel to apply restrictive procedures to low frequency behavior that occurs in their absence rather than relying on less qualified staff to implement the procedure immediately after the behavior occurs.     

Quantification of the effects of chlorpromazine on performance under delayed matching to sample in pigeons.

The effects of four doses of chlorpromazine (dose range 0.5 to 12.5 mg/kg) on performance under a delayed matching-to-sample procedure in pigeons was investigated, using the exponential model of memory (White, 1985). Performance was measured using a bias-free measure of discriminability, log d (Davison & Tustin, 1978), and negative exponential functions were fitted to individual-subject and group data at each dose level. A decrease in matching accuracy was found to be caused by an increase in the rate of forgetting, b, and a decrease in the initial discriminability, log d0. Changes in rate of forgetting and discriminability occurred at doses that had no statistically significant effect on response latency. The exponential model of memory accounted well for the data and provided a useful way of quantifying the effects of chlorpromazine on the processes involved in delayed matching-to-sample performance.     

自适应分组认知诊断测验设计及其选题策略

应用OMST在线装配模式,提出自适应分组认知诊断测验（CD-AMGT）。由于知识状态的先决关系是偏序关系,而且构成格（lattice),利用知识状态当前估计值在格中的上下确界对被试真实知识状态的可能范围进行界定,由此装配下一分组,分组中结合PWKL策略或SHE策略进行选题以兼顾诊断精度、效率和安全性。模拟实验表明,CD-AMGT与PWKL、SHE对比,当题目类型丰富时,以分类准确率略微降低为代价,其题库使用均匀性和计算用时均表现出较大优势。     

肿瘤临床治疗中应关注肝脏

抗肿瘤细胞毒性药物有不同程度毒副作用,有些严重毒副反应是限制药物剂量或使用的直接原因。肝脏是药物代谢的主要器官,也是药物损伤的主要靶器官。随着临床肿瘤治疗关注治疗带来的副作用与关注疗效同等重要的发展,本文对抗肿瘤细胞毒性药物与肝损伤、发生机制、诊断、分型和临床治疗进展进行了阐述。     

腋窝肿物的诊断思路

腋窝肿物虽为外科临床常见病,但其来源及病因多样,部分患者很难确诊。本文就腋窝肿物及其诊断思路做一介绍,应详细询问病史、全面和重点查体、合理选择辅助检查,综合分析进行诊断。     

基于认知设计系统的几何类比推理测验的编制及认知模型分析

认知诊断是一种新的测量范式。本研究首先根据Mulholland,Pellegrino＆Glaser和Whitely＆Schneider关于类比推理的研究结果,采用认知设计系统编制了几何类比推理测试题,并对所编制的测试题的质量进行验证,然后采用口语报告法分析解决几何类比推理所涉及的认知模型,结果表明：1）编制的几何类比推理测试题的质量比较好;2）学生解决类比推理所涉及的认知属性主要为置换、翻转、旋转、数量、大小、颜色与条纹和形状。