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Michael S. Fanselow Joseph P. Decola Beatrice M. De Oca Jesus Landeira-Fernandez 《Aggressive behavior》1995,21(1):63-77
Rats that receive nociceptive electric shock in an environment normally show the conditional fear-induced defensive response of freezing when returned to that environment. If several electric shocks are given in a massed manner they will condition less freezing than the same shocks given in a distributed manner. If a single shock is given immediately after placement in the chamber it does not support any conditioning, although the same shock given after a brief delay does. Electrolytic lesions of the dorsolateral periaqueductal gray (PAG), which damaged dorsomedial, dorsolateral, and lateral PAG, enhanced freezing under these conditions. Lesions of the ventral PAG, which caused extensive damage to the central gray below the aqueduct, reduced conditioning under the more optimal parameters (distributed or delayed shock). This was taken to indicate that both of these regions support different modes of defensive behavior and that when activated, the dorsolateral PAG inbits conditional fear-induced defensive behavior. © 1995 Wiley-Liss, Inc. 相似文献
613.
Robert J. Blanchard Stefano Parmigiani Christopher Bjornson Camlyn Masuda Scott M. Weiss D. Caroline Blanchard 《Aggressive behavior》1995,21(2):123-136
Swiss-Webster mice living in a visible burrow system (VBS) reacted to presentation of a live cat in the surface area of the VBS by retreat to the burrows and reductions in nondefensive behaviors such as eating and drinking. Live eat-exposed subjects remained in the burrows 14 hr or more, while subjects exposed to a toy (plush) cat prior to live cat exposure reemerged almost immediately and made many contacts with the toy cat. However, subjects exposed first to the cat and later to a toy cat showed intermediate surface reemergence times and cat contacts during toy cat tests, indicating strong sensitization effects of prior live cat exposure. Previous studies indicated that rats in this situation show retreat to the burrows, surface avoidance, and reduction in nondefensive behaviors. The mouse pattern was similar, with the notable exception that in the first 5min block after cat presentation, mice rapidly alternated retreat to the burrow chambers with reappearance in the tunnel segment near the surface, to scan the surface visually and sniff. Movement during this time block involved a stretch attend posture characteristic also of risk assessment activities in rats. Such visual and olfactory inspection of the cat is not seen in rats in the VBS. This difference may be related to the finding that rats, but not mice, emit ultrasonic “alarm cries” during and after cat exposure. © 1995 Wiley-Liss, Inc. 相似文献
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The brain dopaminergic system is involved in the process of long-term selection for reduced aggressive reaction towards man in Norway rats. The dopamine levels in the striatum as well as the nucleus accumbens with the tuberculum olfactorium were significantly lower in domesticated rats than in their wild counterparts. A substantial decrease was found in homovanillic acid level in the n. accumbens and tuberculum olfactorium. Specific binding of [3H]spiperone which labels D-2 dopamine receptors was higher in the mesolimbic structure of tame rats, whereas binding of [3H]SCH 23390 (D-1 receptors) was unchanged in this area. No substantial differences were detected in D-1 and D-2 binding in striatum. Apomorphine (0.3 mg/kg) elicited less locomotion in tame animals, reflecting a decrease of sensitivity of postsynaptic dopamine receptors. Tame rats showed fewer aggressive contacts in a foot-shock test than wild rats and the D-2 receptor antagonist sulpiride (25 mg/kg) significantly decreased the foot-shock aggression only in wild rats. Therefore, domestication, which diminishes defensive behavior and emotional reactivity of animals, is associated with decreases of dopamine level in the striatum, changed metabolism of dopamine in mesolimbic system, and an alteration in density and senstivity of D-2 receptors. 相似文献
615.
当今医学科技的发展趋势及我国的发展战略 总被引:14,自引:4,他引:10
巴德年 《医学与哲学(人文社会医学版)》2000,21(2):1-4
作为生命科学最重要组成部分的医学科学走向科技发展的新时代。在下个世纪,科研重点将向生命科学和生命医学转移。充分认识医学科学技术的地位和作用,及当代医学科技发展的主要趋势和特点,制定我国医学科学的发展战略,加强医学高技术的发展,对我国的医学科技发展将具有十分重要的意义。 相似文献
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不同条件下拟合指数的表现及临界值的选择 总被引:2,自引:1,他引:1
在本模拟研究中设计了6种样本容量,6种因子载荷,和4种评分等级,并考察了正态和非正态分布两种情况。采用的错误模型为参数误置(真模型中每个因子各由5个题目来测量,错误模型中则是第一个因子由6个题测量,另两个因子各由4个和5个题来测量,即有一个因子载荷被误置)模型。结果发现(1)样本量、载荷量、评分等级数和分布形态都对GOF的取值确有影响。其中分布形态的影响最大。NNFI、IFI在不同条件下的平均值是最稳定的,其次是CFI、RMSEA和SRMR。它们都算是值得推荐的GOF,尤其是NNFI和IFI。(2)在正态分布中,当样本量≥1000时,根据NNFI、IFI、CFI、RMSEA、SRMR对模型是否拟合做出判断时有很低的两类错误率,在样本量<1000时则不理想。在偏态条件下无论选择哪个GOF两类错误率都很高。(3)采用2指数策略在很多情况下也不能显著降低两类错误率。(4)由于在数据分布非正态,或正态但样本量<1000时是难判断模型是否拟合的。因此我们提出了2界值策略。即为每个GOF确定上下两个界值。低于下界值时可判断模型是不正确的,而高于上界值时则可判断模型是正确的。GOF取值处于上下界值之间时难以判断模型是否拟合,只能说越高拟合的可能性越大。这时就要通过跨样本验证和增加样本量来确定模型是否正确 相似文献
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619.
知识教学中认知策略与原有知识间关系的实验研究 总被引:2,自引:0,他引:2
模拟课堂教学情境,探讨知识教学中学习者的认知策略与原有知识间的相互关系。研究表明,二者存在明显的相互作用,策略学习只有在学习者具备适当原有知识的基础上才能有效地促进学习;当原有知识缺乏时,策略教学对学习成绩没有显著性影响;原有知识水平的高低可直接影响学生的学习成绩。该结论对于实际教学工作具有一定的指导意义。 相似文献
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