Removal of epileptically compromised tissue in the frontal cortex restores oculomotor selection in the antisaccade task

The frontal cortex is heavily involved in oculomotor selection. Here, we investigated the neural correlates of eye movement selection during an antisaccade task in a young epileptic patient in whom the seizure focus included the frontal cortex and affected its function. Before resection surgery, the patient had difficulty in performing correct antisaccades towards the visual field contralateral to the seizure focus. Because the FEF is the only area in the human frontal cortex that is known to have a lateralized oculomotor function in the antisaccade task, this behavioural imbalance between the two visual fields suggests a disruption of FEF functioning by the nearby seizure focus. Electrocorticographic recordings at the seizure focus indeed showed that the seizure focus interfered with correct antisaccade performance. These results were in line with fMRI recordings revealing less task-related frontal activity for the hemisphere of the seizure focus, possibly reflecting diminished top-down engagement of the oculomotor system. Two months after removal of the compromised tissue, the seizures had disappeared, and antisaccade performance was the same for both visual hemifields. We conclude that a seizure focus in the frontal cortex can induce a dysfunction in the selection of eye movements, which is resolved after removal of interfering tissue.     

血管介入治疗与自然力再平衡：从扶持到掣肘

自然力是组织维持稳态的自愈能力,完善的内皮及平滑肌功能构成血管自然力基础。损伤力为打破组织稳态的破坏力。自然力弱于损伤力时,负平衡形成,疾病发生发展,需外援医疗干预扶持恢复自然力平衡。经数代技术革新,介入治疗后的血管事件发生率显著下降,但异物引起慢性炎症及再狭窄问题凸显,介入治疗与血管自然力陷入再狭窄-再介入的"对抗平衡",如何避免这种"掣肘"状态成为血管介入治疗后续的核心问题。生物可吸收支架及可回收支架为适度干预介入理念的新生产物,有望在干预成功后恢复血管自然状态,真正意义上实现自然力再平衡。     

跨通道语义启动对视觉注意的影响

采用生活中的真实客体,考察了跨通道语义相关性对视觉注意的影响以及跨通道促进的时程。结合启动范式和点探测范式,实验1发现在听觉启动600ms后,被试对高相关视觉刺激的反应比对低相关刺激的反应更快,而在视觉启动下没有发现启动效应。实验2发现在启动刺激呈现900ms后跨通道启动效应消失。研究证明了基于先前经验的视、听语义相关能够促进视觉的选择性注意。     

The Evolution of a Scientific Concept

A philosophically comprehended account is given of the genesis and evolution of the concept of protein. Characteristic of this development were not shifts in theory in response to new experimental data, but shifts in the range of questions that the available experimental resources were fit to cope with effectively. Apart from explanatory success with regard to its own range of questions, various other selecting factors acted on a conceptual variant, some stemming from a competing set of research questions, others from an altogether different field of inquiry, and still others from the external environment. These results are best explained on, hence support, an evolutionary model of the progress of experimental investigation, whose outlines are briefly discussed. This revised version was published online in August 2006 with corrections to the Cover Date.     

古尔德——道金斯之争的核心问题

斯蒂芬·杰伊·古尔德和理查德·道金斯是著名的进化生物学家和颇有影响的媒体科学家,他们在进化论的很多方面都有不同意见。“进化是进步的吗?”是古尔德和道金斯之争的核心问题。在追溯这一问题的历史的基础之上,考察古尔德和道金斯观点的分歧以及探讨这种分歧背后的可能原因。     

Choosing the best means to an end: The influence of ingroup goals on the selection of representatives in intergroup negotiations

According to Scheepers, Spears, Doosje, & Manstead (2006), instrumental goals refer to the maximization of profit whereas identity goals are associated with the attainment of a positive social identity. In two experiments, we show that when negotiations are purely instrumental individuals prefer pro-outgroup deviants as representatives (Experiments 1 and 2). In contrast, when negotiations are identity-related, group members increase their preference for normative (Experiments 1 and 2) and pro-ingroup deviants (Experiment 1). Furthermore, these goals also impact perceptions of typicality of group members. Taken together, these results suggest strategic acceptance of deviance when the goal is to bring the other party to concede and increased preference for normativity when identity is the group's main preoccupation. We discuss implications of these results for research on negotiation as well as on the influence of the intergroup context on intragroup dynamics.     

Identifying the situational triggers underlying avoidance of communication situations and individual differences therein

People are actively involved in the selection and avoidance of the situations they face during everyday life. Moreover, such selection/avoidance behavior is subject to sizeable individual differences. Yet, to a large extent this phenomenon has been underinvestigated, and a full understanding of selection/avoidance remains lacking. In the present paper, we take a first step to a more in-depth understanding of situation avoidance, which is conceptualized in terms of individual profiles or signatures across situations. Two key objectives with regard to those signatures are being addressed, that is: (a) identifying the critical situational triggers that elicit avoidance behavior, and (b) identifying the most important individual differences in the link between these situational triggers and avoidance, along with their underlying process dynamics. To achieve these objectives, we performed an empirical study on avoidance of communication situations. This study revealed a set of person types that meaningfully differ in sensitivity to a few key situational features. These person types further appeared to differ from one another on several dispositional cognitive/affective forecast variables.     

Knowledge to Wisdom: We Need a Revolution

Introduction The following document is a very brief summary of a thesis and argument that I have devoted the last 30 years of my life to trying to get across to my fellow human beings. It was first spelled out in What’s Wrong With Science? (Bran’s Head Books, 1976) and subsequently in From Knowledge to Wisdom (Blackwell, 1984), Is Science Neurotic? (Imperial College Press, 2004) and numerous articles, references to which can be found on . Three years ago an international group was formed, called Friends of Wisdom, which seeks to get across to academics and the public the compelling arguments and urgent need to transform academic inquiry so that its basic aim becomes to seek and promote wisdom. The document below is taken from the website of Friends of Wisdom, the URL of which is . It is the mission statement of Friends of Wisdom. You are invited to join.