Precis of <Emphasis Type="Italic">Philosophy and Neuroscience</Emphasis>: <Emphasis Type="Italic">A Ruthlessly Reductive Account</Emphasis>

This book precis describes the motives behind my recent attempt to bring to bear “ruthlessly reductive” results from cellular and molecular neuroscience onto issues in the philosophy of mind. Since readers of this journal will probably be most interested in results addressing features of conscious experience, I highlight these most prominently. My main challenge is that philosophers (even scientifically-inspired ones) are missing the nature and scope of reductionism in contemporary neuroscience by focusing exclusively on higher-level cognitive neuroscience, and ignoring the discipline's cell-physiological and molecular-biological core.     

拓扑性质知觉的大脑半球功能不对称性研究

本文以视觉的拓扑知觉理论为指导进行大脑半球功能不对称性的研究。全文共有三个实验,考察了辨别扭扑性质差异和其它几何性质差异时大脑半球的功能不对称性．拓扑性质差异包括洞（封闭性）的差异和内外关系的差异．实验结果显示：对于右利手被试,辨别拓扑性质差异时,左半球有优势。辨别距离和朝向等几何性质差异时,右半球有优势或没有统计显著的大脑半球功能不对称性。     

Cerebral asymmetry in autonomic conditioning to facial expressions: Sex differences

In the present experiment, sex differences in hemispheric asymmetry during classical conditioning to emotional stimuli are reported. 125 subjects (62 females and 63 males) were shown a slide of a happy face in the right (or left) visual half field (VHF), and simultaneously a slide of an angry face in the left (or right) VHF. Eight groups were formed by the combination of male and female subjects; left and right VHF positions of the angry/happy faces; and the administration/omission of the shock unconditioned stimulus (UCS). Dependent measures were skin conductance responses recorded from both hands. The results during extinction showed a significant larger SCR magnitude to the shock compared to the no-shock groups only for the female subjects. CS position during conditioning was also important in revealing differential responding to either the happy or angry faces. A right hemisphere effect was found for the angry face CS for both the male and female subjects, however with a greater difference for the females.     

Attentional asymmetries in a visual orienting task are related to temperament

Spatial asymmetries are an intriguing feature of directed attention. Recent observations indicate an influence of temperament upon the direction of these asymmetries. It is unknown whether this influence generalises to visual orienting behaviour. The aim of the current study was therefore to explore the relationship between temperament and measures of spatial orienting as a function of target hemifield. An exogenous cueing task was administered to 92 healthy participants. Temperament was assessed using Carver and White's (1994) Behavioural Inhibition System and Behavioural Activation System (BIS/BAS) scales. Individuals with high sensitivity to punishment and low sensitivity to reward showed a leftward asymmetry of directed attention when there was no informative spatial cue provided. This asymmetry was not present when targets were preceded by spatial cues that were either valid or invalid. The findings support the notion that individual variations in temperament influence spatial asymmetries in visual orienting, but only when lateral targets are preceded by a non-directional (neutral) cue. The results are discussed in terms of hemispheric asymmetries and dopamine activity.     

不同任务类型对熟练维汉双语者跨语言启动不对称性的影响

采用两种不同的任务类型对熟练维汉双语者跨语言掩蔽翻译启动效应进行考察,结果发现,在词汇决定任务中,熟练维汉双语者在L1-L2和L2-L1两个方向上均表现出了掩蔽翻译启动效应,但L1-L2方向远大于L2-L1方向,即掩蔽翻译启动效应具有不对称性。而在语义分类任务中,熟练维汉双语者在两个方向上表现出的翻译启动效应量相近,具有对称性。结果支持Kroll的修正层级模型。     

Maternal sensitivity and infant response to frustration: The moderating role of EEG asymmetry

Two hundred and thirty-three 5-month-old infants and their mothers participated in a study designed to examine the influence of maternal sensitivity and infant neurophysiology, as well as interactions between these, on infants’ regulatory behavior and reactivity to emotional challenge. Maternal sensitivity was measured during two mother–child free-play episodes prior to the challenge task. Infant neurophysiology was derived from a measure of resting EEG asymmetry collected during a baseline episode. Infant regulatory behaviors (mother orienting and distraction) and reactivity to challenge (negative affect) were assessed during an arm restraint procedure. Maternal sensitivity predicted mother-orienting behavior for all infants, regardless of baseline EEG asymmetry. Maternal sensitivity also predicted more distraction behaviors for infants with left frontal EEG asymmetry at baseline. In contrast, maternal sensitivity predicted more negative affect for infants with right frontal EEG asymmetry at baseline. These findings lend support for the hypothesis that maternal sensitivity and infant neurophysiological functioning interact to predict regulatory behavior and reactivity and are discussed in terms of the significance for understanding infant regulatory development in the first year of life.     

Asymmetrical hemisphere activation enhances global–local processing

Decades of research focusing on the neurophysiological underpinnings related to global–local processing of hierarchical stimuli have associated global processing with the right hemisphere and local processing with the left hemisphere. The current experiment sought to expand this research by testing the causal contributions of hemisphere activation to global–local processing. To manipulate hemisphere activation, participants engaged in contralateral hand contractions. Then, EEG activity and attentional scope were measured. Right-hand contractions caused greater relative left-cortical activity than left-hand contractions. Participants were more narrowly focused after left-hemisphere activation than after right-hemisphere activation. Moreover, N1 amplitudes to local targets in the left hemisphere were larger after left-hemisphere activation than after right-hemisphere activation. Consistent with past research investigating hemispheric asymmetry and attentional scope, the current results suggest that manipulating left (right) hemisphere activity enhanced local (global) attentional processing.     

Asymmetric Perception of Gains versus Non‐losses and Losses versus Non‐gains: The Causal Role of Regulatory Focus

Recent studies show that, while losses loom larger than equivalent non‐gains, gains loom larger than equivalent non‐losses. This finding has been interpreted within the framework of regulatory focus theory. In this study, we highlight the importance of considering the motivational focus independently of the framing and the valence of outcome, thus exploring the causal effect of regulatory focus on the asymmetric perception of gains versus non‐losses and losses versus non‐gains. In two studies, we examine the perceived effects of either actual or hypothetical changes in monetary wealth, while orthogonally manipulating framing, valence, and regulatory focus. We find a significant interaction between the three factors. The gain versus non‐loss asymmetry in perceived satisfaction is stronger in promotion focus, whereas the loss versus non‐gain asymmetry in perceived dissatisfaction is stronger in prevention focus. The results suggest that the effects of incentives framed in terms of (non)gains and (non)losses depend on their congruence with the individual's motivational state. Copyright © 2013 John Wiley & Sons, Ltd.     

First-person approaches in neuroscience of consciousness: Brain dynamics correlate with the intention to act

The belief in free will has been frequently challenged since Benjamin Libet published his famous experiment in 1983. Although Libet’s experiment is highly dependent upon subjective reports, no study has been conducted that focused on a first-person or introspective perspective of the task. We took a neurophenomenological approach in an N = 1 study providing reliable and valid measures of the first-person perspective in conjunction with brain dynamics. We found that a larger readiness potential (RP) is attributable to more frequent occurrences of self-initiated movements during negative deflections of the slow cortical potentials (SCP). These negative deflections occur in parallel with an inner impulse reported by an expert meditator which may in turn lead to a voluntary act. We demonstrate in this proof-of-principle approach that the first-person perspective obtained by an expert meditator in conjunction with neural signal analysis can contribute to our understanding of the neural underpinnings of voluntary acts.     

Paranoid cognitions,failure, and focus of attention in college students

Three experiments examined aspects of the link between focus of attention, manipulated by use of video camera and monitor, and paranoid and depressive cognitions in a sample of college students. In Experiment 1 participants were exposed to either a failure or neutral task, under high (HSA) or low self-awareness (LSA) conditions. HSA triggered paranoid cognitions on neutral and failure tasks; failure alone triggered depressive cognitions. In Experiment 2 the camera switched focus thrice between participant and experimenter using only neutral tasks. Paranoia scores initially were higher in the HSA condition. Paranoia scores increased when participants moved from LSA to HSA. Paranoia scores never fell when moving from HSA to LSA conditions. Experiment 3 used only HSA and failure, and showed how a priming task that increased the accessibility of either positive or negative self-cognitions led to significantly different paranoia and depression scores.