激活右腹外侧前额叶提高抑郁症患者对社会疼痛的情绪调节能力：一项TMS研究

负性人际交往经历和负性社会事件是抑郁症的重要诱导因素, 而社会功能受损是抑郁症患者的重要特征之一, 患者通常表现出对社会疼痛的情绪失调。为了提高抑郁症患者在负性社交情境中或面对负性社会事件时的情绪调节能力, 本研究采用经颅磁刺激技术(transcranial magnetic stimulation, TMS), 考察抑郁症患者在腹外侧前额叶(the ventrolateral prefrontal cortex, VLPFC)被激活后其情绪调节能力的改变。结果表明, 当右侧VLPFC被TMS激活且患者采用认知重评策略调节情绪时, 实验组患者(n = 64)比对照组患者(n = 63)在社会排斥情境下报告了更弱的负性情绪体验, 这说明激活右侧VLPFC可以有效提高患者对社会疼痛的外显性情绪调节能力。本研究是采用TMS提高抑郁症患者情绪调节能力的首次尝试, 实验发现不但支持了VLPFC与认知重评策略的因果关系, 还为临床改善抑郁症等社会功能障碍患者的情绪调节能力提供了明确的神经治疗靶点。后续研究还需探讨多疗程TMS刺激方案、改变社会疼痛的诱发方式、对比左右侧VLPFC的治疗效果、尝试使用其他的情绪调节策略, 进一步验证本研究的结论, 优化TMS治疗方案。     

Neural correlates of subliminally presented visual sexual stimuli

In the context of forensic psychiatry, it is crucial that diagnoses of deviant sexual interests are resistant to manipulation. In a first attempt to promote the development of such tools, the current fMRI study focusses on the examination of hemodynamic responses to preferred, in contrast to non-preferred, sexual stimuli with and without explicit sexual features in 24 healthy heterosexual subjects. The subliminal stimulus presentation of sexual stimuli could be a new approach to reduce vulnerability to manipulation. Meaningful images and scrambled images were applied as masks. Recognition performance was low, but interestingly, sexual preference and explicitness modulated stimulus visibility, suggesting interactions between networks of sexual arousal and consciousness. With scrambled masks, higher activations for sexually preferred images and for explicit images were found in areas associated with sexual arousal (Stoleru, Fonteille, Cornelis, Joyal, & Moulier, 2012). We conclude that masked sexual stimuli can evoke activations in areas associated with supraliminal induced sexual arousal.     

工作记忆负荷对反馈加工过程的影响:来自脑电研究的证据

个体对行为后反馈结果的加工在学习和环境适应方面有重要意义,工作记忆负荷(working memory load,WM load)如何影响反馈加工过程尚不清楚。采用双任务范式,设置基线、低WM load、高WM load三种条件,结合ERP技术对这一问题进行探究。发现RewP (reward positivity,奖赏正波)对效价敏感,而不受WM load条件影响;Theta震荡的正、负反馈差异波在高WMload条件下比在低WM load条件下小。结果支持等级强化学习-前扣带回理论(HRL-ACC, hierarchical reinforcement learning theory of anterior cingulate cortex)对于RewP和theta震荡的观点:RewP反映了反馈效价评估功能, theta震荡反映了认知控制功能,并且WM load选择性影响了ACC的认知控制功能而不是反馈效价评估功能。     

时间距离对于验证性信息加工的影响

研究基于解释水平理论考察时间距离对于验证性信息加工的影响, 即在个体和组织决策情境中, 人们倾向于偏好选择和高估与自身观点和决策相一致的信息, 而不是非一致性信息。通过4个情境决策实验, 研究结果一致表明近期决策会提高信息搜寻和评估中的验证偏差, 而远期决策会降低它们的验证偏差, 知觉到的决策确定性在其中起到部分中介作用(实验1b)。解释水平(实验2)和期许性/可行性表征(实验3)分别在时间距离对验证性信息加工的影响中起到调节作用, 结果依次表明在低解释水平(高可行性-低期许性特征)条件下, 时间距离与验证性信息加工的负相关关系会得到显著增强, 而在高解释水平(高期许性-低可行性特征)条件下, 时间距离与验证性信息加工的负相关关系会得到显著降低。     

The Influence of Time Estimation and Time‐Saving Preferences on Learning to Make Temporally Dependent Decisions from Experience

In this paper, we merge research related to experiential learning, temporal perception, and the value of time and money by examining decisions where the timing of action (response) determines the outcome received. We predicted that time‐saving preferences and impatience would decrease maximization (i.e., taking action when it returned the largest reward), and that the constraints of temporal perception would compound their effects. Across three studies, participants undershot on average (i.e., responded earlier than the period of time during which a response would return the maximal reward) showed a preference for shorter‐delay options and often did not find the maximal reward. In addition, participants' reliance on temporal perception increased undershooting, increased preferences for shorter‐delay options, and reduced maximization. Nevertheless, participants who found the maximal reward continued to maximize at a high rate rather than opting for shorter delays and smaller rewards. Thus, while most participants appeared to have a preference for saving time, most behaved as reward maximizers rather than temporal discounters. Copyright © 2017 John Wiley & Sons, Ltd.     

信息保持、短时存贮与执行控制的脑模型

工作记忆的脑机制是认知神经科学研究的重要问题。研究者在分析大量脑成像研究数据的基础上,创建了许多解释工作记忆神经基础的模型。Smith和Jonides发展了工作记忆成分结构模型和贮存与执行加工分离模型。Postle和D’Esposito建构了工作记忆相对表征混合模型,D’Esposito, Postle和Rypma阐述了工作记忆加工阶段动态模型。Fletcher和Henson提出工作记忆额叶分区整合理论。该文通过对上述模型或理论的评价,总结了工作记忆脑成像研究中存在的问题,展望了该研究领域的发展趋势。     

Effects of reinforcement history on response rate and response pattern in periodic reinforcement

Several researchers have suggested that conditioning history may have long-term effects on fixed-interval performances of rats. To test this idea and to identify possible factors involved in temporal control development, groups of rats initially were exposed to different reinforcement schedules: continuous, fixed-time, and random-interval. Afterwards, half of the rats in each group were studied on a fixed-interval 30-s schedule of reinforcement and the other half on a fixed-interval 90-s schedule of reinforcement. No evidence of long-term effects attributable to conditioning history on either response output or response patterning was found; history effects were transitory. Different tendencies in trajectory across sessions were observed for measures of early and late responding within the interreinforcer interval, suggesting that temporal control is the result of two separate processes: one involved in response output and the other in time allocation of responding and not responding.     

损毁大鼠双侧内嗅皮质对束缚应激反应的影响

采用大鼠急性束缚应激动物模型,用鹅羔氨酸损毁大鼠双侧内嗅皮质来建立内嗅皮质损伤模型,观察束缚应激1小时后下丘脑室旁核快反应基因c-Fos表达情况以及应激后血浆促肾上腺皮质激素含量的动态变化,并与对照组相比较,探讨内嗅皮质与束缚应激反应的关系。结果表明,损毁内嗅皮质,明显抑制了应激诱导的下丘脑室旁核c-Fos的表达和血浆促肾上腺皮质激素含量的上升。结果提示,内嗅皮质参与调节束缚应激反应时HPA轴功能。     

Framing deductive reasoning with emotional content: An fMRI study

In the literature concerning the study of emotional effect on cognition, several researches highlight the mechanisms of reasoning ability and the influence of emotions on this ability. However, up to now, no neuroimaging study was specifically devised to directly compare the influence on reasoning performance of visual task-unrelated with semantic task-related emotional information.In the present functional fMRI study, we devised a novel paradigm in which emotionally negative vs. neutral visual stimuli (context) were used as primes, followed by syllogisms composed of propositions with emotionally negative vs. neutral contents respectively. Participants, in the MR scanner, were asked to assess the logical validity of the syllogisms. We have therefore manipulated the emotional state and arousal induced by the visual prime as well as the emotional interference exerted by the syllogism content.fMRI data indicated a medial prefrontal cortex deactivation and lateral/dorsolateral prefrontal cortex activation in conditions with negative context. Furthermore, a lateral/dorsolateral prefrontal cortex modulation caused by syllogism content was observed. Finally, behavioral data confirmed the influence of emotional task-related stimuli on reasoning ability, since the performance was worse in conditions with syllogisms involving negative emotions. Therefore, on the basis of these data, we conclude that emotional states can impair the performance in reasoning tasks by means of the delayed general reactivity, whereas the emotional content of the target may require a larger amount of top-down resources to be processed.