A model and algorithm for multidimensional scaling with external constraints on the distances

A method for externally constraining certain distances in multidimensional scaling configurations is introduced and illustrated. The approach defines an objective function which is a linear composite of the loss function of the point configurationX relative to the proximity dataP and the loss ofX relative to a pseudo-data matrixR. The matrixR is set up such that the side constraints to be imposed onX's distances are expressed by the relations amongR's numerical elements. One then uses a double-phase procedure with relative penalties on the loss components to generate a constrained solutionX. Various possibilities for constructing actual MDS algorithms are conceivable: the major classes are defined by the specification of metric or nonmetric loss for data and/or constraints, and by the various possibilities for partitioning the matricesP andR. Further generalizations are introduced by substitutingR by a set ofR matrices,R _i ,i=1, ...r, which opens the way for formulating overlapping constraints as, e.g., in patterns that are both row- and column-conditional at the same time.     

Individual,family, and societal dimensions of genetic discrimination: A case study analysis

Background. As the development and use of genetic tests have increased, so have concerns regarding the uses of genetic information. Genetic discrimination, the differential treatment of individuals based on real or perceived differences in their genomes, is a recently described form of discrimination. The range and significance of experiences associated with this form of discrimination are not yet well known and are investigated in this study. Methods. Individuals at-risk to develop a genetic condition and parents of children with specific genetic conditions were surveyed by questionnaire for reports of genetic discrimination. A total of 27,790 questionnaires were sent out by mail. Of 917 responses received, 206 were followed up with telephone interviews. The responses were analyzed regarding circumstances of the alleged discrimination, the institutions involved, issues relating to the redress of grievances, and strategies to avoid discrimination. Results. A number of institutions were reported to have engaged in genetic discrimination including health and life insurance companies, health care providers, blood banks, adoption agencies, the military, and schools. The alleged instances of discrimination were against individuals who were asymptomatic and sometimes impacted on other asymptomatic relatives. Few surveyed respondents knew of the existence of institutions such as state insurance commissions or the Medical Information Bureau, Inc., which may play roles in redress of grievances or correction of misinformation. Conclusions. Genetic discrimination is variable in form and cause and can have marked consequences for individuals experiencing discrimination and their relatives. The presence of abnormal genes in all individuals makes each person a potential victim of this type of discrimination. The increasing development and utilization of genetic tests will likely result in increased genetic discrimination in the absence of contravening measures. All authors contributed equally to this work. This work was supported by a grant from the U.S. Department of Energy and funding from the Department of Mental Retardation of the Commonwealth of Massachusetts.     

Loglinear multidimensional IRT models for polytomously scored items

A loglinear IRT model is proposed that relates polytomously scored item responses to a multidimensional latent space. The analyst may specify a response function for each response, indicating which latent abilities are necessary to arrive at that response. Each item may have a different number of response categories, so that free response items are more easily analyzed. Conditional maximum likelihood estimates are derived and the models may be tested generally or against alternative loglinear IRT models.Hank Kelderman is currently affiliated with Vrije Universiteit, Amsterdam.We thank Linda Vodegel-Matzen of the Division of Developmental Psychology of the University of Amsterdam for making available the data used in the example in this article.     

Kant,health care and justification

An argument based on Kant for access to health-care for all is a most helpful addition to prior discussions. My paper argues that while such a point of view is helpful it fails to be persuasive. What is needed, in addition to a notion of the legislative will, is a viewpoint of community which sees justice as originating not merely from considerations of reason alone but from a notion of community and from a framework of common human experiences and capabilities.     

Billing and Record-Keeping for Familial Cancer Risk Counseling: A National Survey

We surveyed 111 genetic counselors providing cancer risk counseling (CRC) in order to document their billing and record-keeping practices. Of the 75 respondents, billing was generally done under the supervising physician with a wide variation in charges. Follow-up telephone interviews with 28 counselors who charge patients revealed that billing was usually done using the CPT codes for consultations, and the ICD-9 diagnostic codes for cancer (if applicable), a medical complaint, or a family history of cancer code. Most counselors exclude some clinical information from the patient's medical record. In consultation notes, 81% of counselors document a discussion of genetic testing, but only 37% document the patient's actual testing decision, and only 19% document test results. In anticipation of increased referrals for CRC, data are needed on the components of a CRC visit, the amount of time required to provide CRC, patient outcomes measures, and charges and reimbursement. The feasibility and advisability of keeping results separate from the patient's medical record also needs to be addressed.     

Hemispheric asymmetry effects in children studied by dichotic listening and visual half-field testing

Dichotic listening (DL) and visual half-field (VHF) testing were used to study hemisphere asymmetry in a developmental perspective. Five-, 8-, and 11-year-old children were presented lists of fused words using a DL technique in Experiment 1, and 8- and 11-year-old children were presented pictures of common objects using a VHF technique in Experiment 2. In both experiments, measures of identification, free recall, and recognition of the words/pictures were employed. The results revealed effects of ear input (right-ear advantage) and half-field presentation (right visual half-field advantage) for all age groups, although the magnitude of this lateralization effect differed between the three memory measures. The results are discussed in relation to developmental aspects of language laterality, and in relation to the clinical utility of non-invasive lateralization techniques.     

Constructing measures with maximum reliability

The scoring of response vectors to give maximum test-retest correlation is investigated. Simple sufficiency arguments show that the form of the best scores is very restricted. A general method is given for finding the best scores, deriving the best scores for the normal factor model, and showing by calculation of several particular cases that for a standard model for binary response it is easy to approximate the best scores.     

Interim Managers: Distinguishing Personality Characteristics of Managers on Short-term Contracts

The use of interim managers by companies is increasing, and reasons for this trend are discussed. A study is reported in which the normative personality make-up of a group of interim managers is compared with that of a general sample of UK managers. Ninety-four interim managers completed the revised PA Preference Inventory (PAPI-N) and the results are compared with those from a general UK managerial sample. Statistically significant differences are reported for 12 out of 20 scales, with nine of the effect sizes ≥ 0.5. Results are also compared with a priori job expert predictions. Of nine predictions that interim managers would differ from the general management norm, seven are consistent with the statistical findings. Practical and methodological implications of the findings, and their relation to the ‘Big Five’, are discussed, together with broader implications for the study of workers in new and emerging forms of employment. The findings are also interpreted in the particular context of interim management roles.     

Book Reviews

Books reviewed: Robert Shaw Trust in the Balance; Building Successful Organizations on Results, Integrity and Concern Louis H. Janda Psychological Testing: Theory and Applications David Ulrich, Michael R. Losey and Geraldine Lake, (eds) Tomorrow's HR Management: 48 Thought Leaders Call For Change     

Book Reviews

John Arnold, Cary Cooper and Ivan T. Robinson, Work Psychology Jan Te Nijenhuis, Comparability of Test Scores for Immigrants and Majority Group Members in the Netherlands David A. Nadler with Mark B. Nadler, Champions of Change: How CEO’s and their Companies are Mastering the Skills of Radical Change