多巴胺、5-羟色胺通路相关基因及家庭环境对创造力的影响及其作用机制

创造力的遗传基础是近年来创造力研究领域的前沿和热点问题, 但仍尚处于起步阶段, 也未有研究系统探讨遗传与环境因素的交互作用对创造力的影响及其作用机制。本课题拟在中国汉族人群中考察多巴胺(DA)、5-羟色胺(5-HT)神经递质通路上的32个基因约700个多态性位点与创造力的关系, 并首次探讨家庭环境在遗传多态性与创造力关系中的调节作用。研究内容包括：(1)通过单基因、基于通路以及基因—基因交互作用的关联分析, 考察遗传多态性对创造力的影响, 揭示创造力的遗传基础; (2)通过基因—环境交互作用的关联分析, 考察家庭环境在遗传与创造力关系中的调节作用; (3)通过结构方程模型的比较分析, 揭示遗传与家庭环境在创造力两个方面(创造思维与创造人格)共享的与特异的作用机制。该项目成果能够从遗传与环境交互作用的角度阐明创造力个体差异的原因, 有助于构建基于创造力个体差异分析的理论模型, 对创造人才的鉴别和培养具有重要现实意义。     

Biological Implications of Gene–Environment Interaction

Gene–environment interaction (G × E) has been treated as both a statistical phenomenon and a biological reality. It is argued that, although there are important statistical issues that need to be considered, the focus has to be on the biological implications of G × E. Four reports of G × E deriving from the Dunedin longitudinal study are used as exemplars of the biological considerations that should lead to an hypothesis-driven choice of the specific genetic polymorphisms and the specific environmental influence to be investigated. The same four studies are used to discuss how the assessment of internal and external validity can be undertaken and how experimental approaches in humans and with animal models may be informative in the elucidation of the relevant operative biological mechanisms.     

班级生态系统对儿童亲社会行为影响的研究述评

依据生态系统观以及班级环境中亲社会行为研究的进展,在班级环境中,与儿童人际互动最密切,对其亲社会行为具有重要影响的两类人群是——同伴和教师。作者把儿童与同伴、儿童与教师之间的互动关系作为班级环境中两个重要生态子系统,依次介绍了班级环境中这两个生态子系统的各成分,以及它们对儿童亲社会行为的影响。文章最后指出,该领域的研究应注重人际间的双向互动、基于观察的互动模式研究、以及重视时间变量对行为过程的影响     

家庭环境类型与青少年亲子冲突解决的关系

以北京829名普通中学生为被试.探讨了家庭环境类型与亲子冲突解决的关系.结果表明: (1)高亲密度、高情感表达、低矛盾性的家庭在亲子冲突解决的关系目标上的得分显著高于其它类型家庭;低亲密度、低表达性、高矛盾性的家庭在权力、公平、自认和自主目标上的得分显著高于其它类型家庭. (2)高亲密度、高表达性、低矛盾性的家庭更多使用积极的冲突解决策略;低亲密度、低表达性、高矛盾性的家庭更多使用消极的冲突解决策略.说明不同家庭环境类型下的青少年亲子冲突解决有不同的特点.     

遗传与环境在食管癌发生发展中的作用

食管癌是我国最常见的恶性肿瘤之一,有明显的地域分布特征,提示环境起着主要作用。但近年来有大量研究表明遗传因素在食管癌的发生中起着不可忽视的作用。食管癌是多种因素作用,多基因参与的疾病,是环境与遗传共同作用的结果。     

Progress in the Molecular-Genetic Study of Intelligence

ABSTRACT— The past decade has seen a major shift in the genetic study of human intelligence; where classic studies aimed to quantify the heritability of intelligence, current studies aim to dissect this heritability into its molecular-genetic components. Five whole-genome linkage scans have been published in the past year, converging on several chromosomal (or genomic) regions important to intelligence. A handful of candidate genes, some of which lie in these genomic regions, have shown significant association to intelligence and the associations have been replicated in independent samples. Finding genes brings us closer to an understanding of the neurophysiological basis of human cognition. Furthermore, when genes are no longer latent factors in our models but can actually be measured, it becomes feasible to identify those environmental factors that interact and correlate with genetic makeup. This will supplant the long nature–nurture debate with actual understanding.     

学校归属感与学生发展的探索研究

采用问卷调查法探讨中小学生的学校归属感与学校适应、自我概念、同伴关系及班级环境的关系。结果表明:1)学校适应、自我概念、同伴关系和班级环境与中小学生的学校归属感有密切的关系;2)学校归属感能有效的预测学生的自我概念;3)师生关系和同伴关系对学校归属感有重要影响,是学校归属感显著的预测变量;4)学校类型对学校归属感有显著的影响,重点中学学生的学校归属感显著高于其他类型学校的学生。     

青少年学生的人际信任度与家庭因素的相关研究

该文对青少年学生的人际信任度与家庭因素的关系进行研究,结果表明:1)青少年学生人际信任度的性别差异不显著;2)青少年学生人际信任度的年级差异显著:大学生的人际信任水平最低,初中生的最高,职业中专学生的与大学生的相近;3)青少年学生的人际信任度与其家庭环境的相关不显著。     

A longitudinal and multi-method examination of interest–occupation congruence within and across time

Remarkably little research has addressed change and stability in person–environment fit across time. The objective of the current study was to address this gap in the literature by investigating Holland interest–occupation congruence across time for a sample of college alumni (N = 167) that were tracked during the first third of their professional career. Congruence was examined in all its complexity, including a repeated assessment of both occupations and interests, the use of objective (O*NET) and subjective (self-report) environment assessment methods, and adopting sophisticated congruence calculation methods (i.e., Euclidean distance and profile correlation). This resulted in a total of 12 interest–occupation comparisons within and across time that could be related to general and career specific well-being. The results first indicated moderate levels of stability in interests and occupations across the 15-year time interval, yet also with room for change. Congruence analyses indicated significant interest–occupation fit at the beginning of the career and 15 years later, with the magnitude of congruence slightly varying depending on which occupation assessment and which congruence method was used. Profile correlation congruence did not change over time in absolute terms and evidenced relative stability. Euclidean distance indices had little relative stability over time but did manifest some absolute changes in levels of congruence. Finally, job change moderated the association between interest–occupation congruence and life satisfaction in such a way that higher levels of satisfaction were reported only when little job change was present.