免疫性疾病治疗新途径：诱导细胞程序性死亡

免疫性疾病是一大类难治性的免疫紊乱而造成的疾病,尤其是自身免疫性疾病的一直困扰着免疫学家。传统的免疫治疗是根据不同疾病的需要增强免疫,调节免疫和抑制的方式进行,以辩证的观点分析免疫的增殖与程序性死亡这一对矛盾,认为：免疫性疾病的本质是免疫细胞增殖与程序性恨的失衡,因而通过诱导免疫细胞程序性死亡将成为免疫治疗的新途径。     

The Program Environment Scale: Assessing Client Perceptions of Community-Based Programs for the Severely Mentally Ill

The Program Environment Scale (PES) was developed for use with clients of community-based programs for the severely mentally ill. It is intended to fill the gap in available tools for assessing clients' perceptions of program functioning as it affects their quality of life in a program. Formal pretests were conducted with 121 clients at 12 randomly selected programs near Washington, DC. The final field test used a revised form (29 domains; 129 items) with 221 clients in 22 programs selected randomly throughout the U.S., including Clubhouse, day treatment, psychosocial rehabilitation, and social club programs. Twenty-three subscales met at least five of eight psychometric criteria for internal consistency and discriminant validity. A 24th subscale was retained because of its substantive importance. Successful subscales cover program atmosphere and interactions (program cares about me, energy level, friendliness, openness, staff-client and client-client respect, reasonable rules, availability of positive physical contact, protection from bad touch, staff investment in their jobs, and confidentiality), client empowerment/staff-client equality (program and treatment empowerment, egalitarian space use), and service components (support for paid work, work importance, emergency access, family activities, housing, public benefits, community activities, medications, substance abuse, and continuity). Subscale validity is indicated by associations of specific service offerings with scores on scales measuring client perceptions of those services, and by an ability to differentiate among program models (i.e., Clubhouses, day treatment programs, and psychosocial rehabilitation programs look different from each other). Subscale scores were not influenced by client characteristics (gender, race, age, diagnosis, number of hospitalizations, length of time in program). The final scale has 97 items and takes about 25 minutes to complete. The PES succeeds in measuring different aspects of programs as clients perceive them. In the programs we visited, directors felt the PES covers the important things they want to know about how clients perceive their program. The PES should become a useful tool both for researchers interested in how client responses to programs may influence their therapeutic outcomes, and for practitioners interested in improving their clients' program experiences and/or increasing convergence of staff and client views of their program.     

A SCIENTIST AND A THEOLOGIAN SEE THE WORLD: COMPROMISE OR SYNTHESIS?

Abstract. A scientist (for whom the world is the universe) and a theologian (for whom the world is planet Earth) engage in dialogue, not contrived Platonic or Galilean dialogue, but true bidisciplinary dialogue that strives for higher viewpoint. S: Is the preservation of the human species a primary human responsibility? T: It may be a responsibility we share with God. S: The human species has a limited future if confined to the planet Earth. We must diversify our habitat by colonizing space. T: We are responsible for other life on the planet as well. The discussants conclude that besides protecting Earth ecologies, we should create new ecologies in space.     

PROVIDING A LESS RESTRICTIVE ENVIRONMENT FOR PROFOUNDLY RETARDED PERSONS BY TEACHING INDEPENDENT WALKING SKILLS

A basic right of all handicapped persons is to live in the least restrictive environment possible. In this investigation, procedures were evaluated for teaching four institutionalized males with profound retardation necessary skills to increase their individual freedom of movement. Following baseline, a travel training program with a backward chaining format was implemented to teach each person to walk independently from his living area to school. Travel training included instructions, practice, praise, feedback, verbal reprimands, prompts, and edible reinforcers. Each resident began walking the entire distance to school independently during training and also began walking back to the living area, although the latter set of skills was not specifically trained. Following termination of the formal investigation, follow-up measures of 1 to 8 weeks showed the residents continued going to school independently. A survey of residential facilities in 43 states provided social validation for the seriousness of the problems associated with transporting seriously retarded persons to school. Also, time efficiency measures indicated that training independent travel resulted in reductions of staff time required in school transportation. Results were discussed in light of the potential contributions of behavior analysis in providing less restrictive environments for seriously handicapped persons.     

Nature of relations between the physical and social microenvironment of the two-year-old child

Previous research has demonstrated that high levels of noise, crowing or person traffic pattern in infants' homes are associated with less involved and less responsive caregiving by parents. Based on these previous findings two questions were investigated in the present research. First, does the same pattern of relations appear with older toddlers; second, are these patterns unique to the specific dimensions of noise, crowding and traffic pattern? Subjects were 56 2-year-old toddlers. Based upon repeated home observations the physical and social environments fo the toddlers' homes were assessed using codes from the Purdue Home Stimulation Inventory. Analysis of the interrelation between the phychology and social microenvironments of these toddlers was based upon canonical correlation. Congruent with preovious research, interpretation of the canonical structure revealed that high levels of noise, crowding or traffic pattern in the home were associated with lower caregiver attentiveness and responsivity. Results also indicated that this pattern was unique to the specific physical environment dimensions of noise, crowding and traffic pattern. Implications of these results for alternate care settings are discussed.     

Assessing the Child's Cognitive Home Environment Through Parental Report; Reliability and Validity

In a series of investigations with poor minority families, we examined the reliability and validity of the StimQ, an office-based interview of children's cognitive home environment. Researchers and practitioners alike recognize the importance of assessing meaningful dimensions of children's early experiences, particularly in families where children may be at risk for later cognitive delay. To date, methodological approaches to the study of parenting have most often relied on home visits and/or labour-intensive observations and coding. Our findings suggest that valid and reliable data about the cognitive environments of poor children can be obtained through maternal report, thereby offering applied scientists a useful alternative to assessing children's early experiences. © 1996 John Wiley & Sons, Ltd.     

How drivers adapt their behaviour to changes in task complexity: The role of secondary task demands and road environment factors

The present study investigates the impact of different sources of task complexity such as driving demands and secondary task demands on driver behaviour. Although much research has been dedicated to understanding the impact of secondary task demands or specific road traffic environments on driving performance, there is little information on how drivers adapt their behaviour to their combined presence. This paper aims to describe driver behaviour while negotiating different sources of task complexity, including mobile phone use while driving (i.e., calling and texting) and different road environments (i.e., straight segments, curves, hills, tunnels, and curves on hills). A driving simulator experiment was conducted to explore the effects of different road scenarios and different types of distraction while driving. The collected data was used to estimate driving behaviour through a Generalized Linear Mixed Model (GLMM) with repeated measures. The analysis was divided into two phases. Phase one aimed to evaluate driver performance under the presence and absence of pedestrians and oncoming traffic, different lanes width and different types of distraction. The second phase analysed driver behaviour when driving through different road geometries and lane widths and under different types of distraction. The results of the experiment indicated that drivers are likely to overcorrect position in the vehicle lane in the presence of pedestrians and oncoming traffic. The effect of road geometry on driver behaviour was found to be greater than the effect of mobile phone distraction. Curved roads and hills were found to influence preferred speeds and lateral position the most. The results of this investigation also show that drivers under visual-manual distraction had a higher standard deviation of speed and lateral position compared to the cognitive distraction and the non-distraction condition.     

Physical framework for a counselling environment in India: Thematic analysis of counsellors' perceptions

The influence of the physical environment on the counselling process is an inevitable part of a counselling session. However, there is little insight in Indian research into the desirable elements of the physical environment of the counselling room that helps facilitate a counselling session. Interviews were conducted with 10 professional counsellors in India. Thematic analysis of the data brought out various Basic and Organising themes under the following three Global themes: (a) Elements of the physical framework; (b) Counsellor's perspectives about the physical framework in counselling; and (c) Motivation to build a framework. The findings show how counsellors can systematise the physical framework to help construct the counselling session effectively.     

Genetic and Environmental Contributions to Common Psychopathologies of Childhood and Adolescence: A Study of Twins and Their Siblings

We report findings based on analyses of self-reports of six common adolescent psychopathologies (attention deficit/hyperactivity disorder, ADHD; conduct disorder, CD; oppositional defiant disorder, ODD; generalized anxiety disorder, GAD; separation anxiety disorder, SAD; and major depressive disorder, MDD) in a sample of 1,162 male and female adolescent (12–19 years) twin pairs and 426 siblings. Prevalence statistics for past year and lifetime reports confirm differences between genders for CD, GAD, SAD, and MDD, and a lack of differences between twins and their non-twin siblings. Biometrical modeling was conducted to ascertain the relative influences of genes, and shared and non-shared environments contributing to these disorders. A more robust estimate of these parameters was obtained by including non-twin siblings. Age-specific thresholds were integrated into the analyses to appropriately model the developmental patterns of behavior. We found evidence for both genetic and non-shared environmental influences for all disorders. Shared environmental influences also seem to be important for MDD and lifetime GAD.