Both exposure to a novel context and associative learning induce an upregulation of AKAP150 protein in mouse hippocampus

A-kinase anchoring protein 150 (AKAP150) is a multi-enzyme signaling complex that coordinates the action of PKA, PKC, and PP2B at neuronal membranes and synapses. We measured levels of AKAP150 protein in the hippocampus 6h after training mice in a contextual fear conditioning paradigm. In contextual fear conditioning mice learn to associate a context with a footshock presentation. Mice were divided in four experimental groups with different training protocols: naive, no footshock exposure, immediate footshock exposure, and footshock 3min after exposure to the context. We found that AKAP150 protein levels were increased upon exposing mice to the novel context independent of the training protocol. However, when the animals were habituated to the experimental context, only mice that learned to associate the context with the footshock showed an upregulation of AKAP150. We suggest that upregulated levels of AKAP150 contribute to processing the exposure to a novel context and associative learning.     

Concurrent excitors limit the extinction of conditioned fear in humans

In a human fear conditioning experiment, with on-line expectancy ratings and electrodermal responding as indices of fear, two neutral stimuli (pictures of geometric shapes) were first established as reliable predictors of an electric shock. In the subsequent extinction phase, the two stimuli were repeatedly presented in compound, without the shock. The final test phase consisted of individual stimulus presentations again, which resulted in a strong return of the conditioned responses. This effect was not observed in non-conditioned control stimuli. Hence, behavioral effects of extinction seem highly specific to the stimulus constellation that has gone through the extinction procedure. We argue that pharmacological, behavioral and/or cognitive manipulations that could prevent configural processing of stimulus constellations have direct clinical potential.     

Spider fear and covariation bias in children and adolescents

Covariation bias can be defined as phobic people's tendency to overestimate the association between fear-relevant stimuli and negative outcomes. The current article presents two studies that examined this type of cognitive bias in children and adolescents aged 8-16 years. Study 1 was concerned with a thought experiment during which youths (N=150) were asked to imagine that they participated in an experiment during which they had to view a series of pictures showing spiders, guns, and flowers, that were occasionally followed by a negative outcome (i.e., a mild electric shock). Participants were asked to estimate the relation between each type of picture and the negative outcome. The results indicated that youths with higher levels of spider fear displayed a specific tendency to relate spider pictures to a negative outcome. In Study 2, youths (N=220) actually participated in a computer game during which they were confronted with pictures of spiders, guns, and flowers, each of which was equally often followed by a negative (i.e., losing candy), positive (i.e., winning candy), or neutral outcome. After the game, participants had to estimate the relation between each type of picture and various outcomes. It was found that youths with higher levels of spider fear estimated more negative and less positive outcomes in relation to spider pictures. Taken together, these findings provide support for a fear-related covariation bias in youths. Further developmental analyses indicated that this type of cognitive bias seems to be more consistently present among adolescents than among children.     

Specificity of Disgust Domains in the Prediction of Contamination Anxiety and Avoidance: A Multimodal Examination

Although core, animal-reminder, and contamination disgust are viewed as distinct “types” of disgust vulnerabilities, the extent to which individual differences in the three disgust domains uniquely predict contamination-related anxiety and avoidance remains unclear. Three studies were conducted to fill this important gap in the literature. Study 1 was conducted to first determine if the three types of disgust could be replicated in a larger and more heterogeneous sample. Confirmatory factor analysis revealed that a bifactor model consisting of a “general disgust” dimension and the three distinct disgust dimensions yielded a better fit than a one-factor model. Structural equation modeling in Study 2 showed that while latent core, animal-reminder, and contamination disgust factors each uniquely predicted a latent “contamination anxiety” factor above and beyond general disgust, only animal-reminder uniquely predicted a latent “non-contamination anxiety” factor above and beyond general disgust. However, Study 3 found that only contamination disgust uniquely predicted behavioral avoidance in a public restroom where contamination concerns are salient. These findings suggest that although the three disgust domains are associated with contamination anxiety and avoidance, individual differences in contamination disgust sensitivity appear to be most uniquely predictive of contamination-related distress. The implications of these findings for the development and maintenance of anxiety-related disorders marked by excessive contamination concerns are discussed.     

Neuroscientific evidence for defensive avoidance of fear appeals

Previous studies indicate that people respond defensively to threatening health information, especially when the information challenges self‐relevant goals. The authors investigated whether reduced acceptance of self‐relevant health risk information is already visible in early attention allocation processes. In two experimental studies, participants were watching high‐ and low‐threat health commercials, and at the same time had to pay attention to specific odd auditory stimuli in a sequence of frequent auditory stimuli (odd ball paradigm). The amount of attention allocation was measured by recording event‐related brain potentials (i.e., P300 ERPs) and reaction times. Smokers showed larger P300 amplitudes in response to the auditory targets while watching high‐threat instead of low‐threat anti‐smoking commercials. In contrast, non‐smokers showed smaller P300 amplitudes during watching high as opposed to low threat anti‐smoking commercials. In conclusion, the findings provide further neuroscientific support for the hypothesis that threatening health information causes more avoidance responses among those for whom the health threat is self‐relevant.     

Does the courage measure really measure courage? A theoretical and empirical evaluation

Courage has seen an explosion of research in all branches of psychology, and the most popular measure is Norton and Weiss’s the courage measure (CM). Despite widespread use, limited investigations into its psychometric properties and validity have been performed. To ensure the strength of findings drawn from the scale, the current study performs a theoretical, psychometric, and empirical analysis of the CM. The results demonstrate that the CM has theoretical concerns stemming from the operational definition of courage used during its creation, and may not actually measure courage. Also, the CM was shown to consist of two dimensions separated by regular and reverse coding. Next, the scale demonstrated slight concerns with method effects, and its construct validity was analyzed. Together, the results demonstrate that the CM would benefit from the removal of reverse coded items, and may actually gage persistence despite fear rather than courage.     

负面评价恐惧的性别差异:基于内隐和外显测量的比较

从内隐和外显两种角度探讨负面评价恐惧的性别差异。采用简式内隐联系测验(BIAT)和简明负面评价恐惧量表(BFNES)两种测量方法,实验共72名被试,每名被试先进行简式内隐联系测验,再完成简明负面评价恐惧量表,并借鉴不同方法对两种测量结果进行分析。结果发现:(1)被试的内隐负面评价恐惧与外显负面评价恐惧不存在显著相关,结果产生实验性分离;(2)负面评价恐惧不存在显著性别差异;(3)但有趣的是,不同性别被试内隐和外显负面评价恐惧的分离状况存在显著差异,其中男性的外显负面评价恐惧低于内隐负面评价恐惧,而女性的结果刚好相反,其外显负面评价恐惧高于内隐负面评价恐惧。这些结果表明被试的内隐和外显负面评价恐惧虽然不存在显著性别差异,但不同性别被试的内隐负面评价恐惧和外显负面评价恐惧内部存在不同的组合状况。     

生命回顾疗法介入晚期癌症患者死亡恐惧的实践探索

聚焦晚期癌症患者死亡恐惧,分析比较生命回顾疗法的实际应用。基于临床服务案例,医务社工发现晚期癌症患者的死亡恐惧主要受躯体症状、疾病归因、家庭支持和心性支持四方面影响。医务社工通过运用生命回顾疗法对晚期癌症患者进行干预,依托建立早期良好专业关系、正视死亡恐惧、回顾重要生命事件、强化/修复重要关系、增强自我认同五大策略,赋予患者生命新的价值和希望,实现生命意义的整合,有效缓解个体死亡恐惧,改善末期生命质量。

     

对死亡恐惧的形而上追问

死亡恐惧与自我意识相伴而生,成为人类无法根除的永恒性焦虑。它既根源于他人之死呈现出的经验性恐惧,也来自于拒斥死亡的社会文化所导致的认知性恐惧以及面临“自我”之死时产生的形而上恐惧。死亡恐惧不能彻底消解只能消减,保持适当的死亡恐惧是必要的,也是有益的,它是人类一切精神性追求的内在动力。人们通常力求通过外向性的追求去摆脱或超越死亡恐惧,然而只有通过反躬自省,不假外求的方式,才能最终完成对生命的觉解与超越。     

条件性恐惧提取消退的性别差异

基于记忆再巩固理论的提取消退范式能够有效地削弱非适应性恐惧记忆。性别差异是个体差异性研究的关键变量, 但在提取消退范式的研究中仍然比较少见关于性别差异的探索。因此本研究以立体几何图形作为条件刺激, 腕部电击作为非条件刺激, 皮肤电反应为恐惧反应指标, 探究提取消退范式在恐惧消退效果上是否存在性别差异。结果表明, 在恐惧自发恢复测试中, 提取消退范式的所有被试都成功抑制了恐惧复发, 但恐惧重建测试中只有女性被试抑制了恐惧复发。这说明, 提取消退范式在抑制恐惧自发恢复方面效果显著, 在恐惧重建上女性的消退效果显著优于男性。