即刻消退缺损的原因分析及其神经生物学机制

即刻消退缺损(immediate extinction deficit, IED)是指在条件性恐惧习得后, 立即进行的消退训练不能长期抑制恐惧记忆的现象。IED可能与消退起始时的应激水平和事件分割等因素有关。在高应激水平下, 消退记忆的巩固受损导致IED; 而在中等或较低的应激水平条件下, 即刻消退有效但效果可能容易受事件分割的影响。IED的神经生物学机制涉及应激激活蓝斑去甲肾上腺素能系统, 去甲肾上腺素引起杏仁核基底外侧核(basolateral amygdala, BLA)过度兴奋, 然后BLA通过投射突触抑制在恐惧消退中起核心作用的内侧前额叶神经元的活动。未来研究应注意即刻消退缺损引起的长期后果, 并深入探讨如何优化即刻消退在临床上的应用。     

树大招风：社交焦虑者的正性评价恐惧

正性评价恐惧是社交焦虑能够有效鉴别于抑郁症的核心特征。正性评价恐惧是指对他人给予的积极评价感到恐惧, 并因此而担忧的一种情绪反应。正性评价恐惧不仅会使社交焦虑者表现出否认积极认知、回避关注及情绪消极化等特点, 还会通过去正性化思维和解释偏向进一步加剧其认知偏差并抑制其正性情绪, 从而维持和加剧个体的社交焦虑症状。未来研究应关注正性评价恐惧在教育和咨询中的应用, 以及本土倡导谦虚文化背景下正性评价恐惧特点的研究。     

‘When Would You Do It?’ An Investigation into the Effects of Retaliation,Seriousness of Malpractice and Occupation on Willingness to Blow the Whistle

A questionnaire study involving white collar workers (n=48) investigated the effects of the threat of retaliation, seriousness of malpractice and occupational status of the observer on the likelihood and method of whistle-blowing chosen. In line with previous whistle-blowing and bystander intervention research, the likelihood of whistle-blowing was greater for serious malpractices and where threatened retaliation was low. The effect of retaliation was only significant for serious white collar malpractices and in every situation internal whistle-blowing was more likely than external. The general likelihood of whistle-blowing was positively correlated with the perception that reporting the malpractice would result in change.     

Defensive reactions of “wild-type” and “Domesticated” wild rats to approach and contact by a threat stimulus

Selective breeding of wild rats over many generations on the basis of low or high defensive threat and attack to human approach and contact has produced highly polarized “domesticated” and “wild-type” animals. Because the selection procedure selectively involves these two defense patterns, and these clearly differ in the two groups, it is of interest to determine if other, nonselected, defensive behaviors to threat stimuli also change. “Domesticated” and “wild-type” rats of the thirty-fifth generation were run in a fear defense test battery (F/DTB) to systematically evaluate defensive behaviors to a variety of present threat stimuli. “Domesticated” rats showed reduced avoidance and slower flight speed to an approaching experimenter, reduced jump/startle response to handelap and dorsal contact, less vocalization and boxing to vibrissae stimulation or to an anesthetized conspecific, and reduced defensiveness to an attempted pickup by the experimenter. These results indicate that selective bi-directional breeding for defensive threat and attack to human approach and contact produces group differences in a variety of defensive behaviors, and in defensiveness to stimuli other than those on which the selection was based. © 1994 Wiley-Liss, Inc.     

Pregrouping aggression and defense scores influences alcohol consumption for dominant and subordinate rats in visible burrow systems

Five male/two female rat colonies were established in visible burrow systems, with males selected for pregrouping attack scores and also evaluated in open field and cat odor tests. Dominant-subordinate pregrouping attack differences suggested that the males becoming dominant are those showing more persistent and higher level attack. For six colonies showing dominant-subordinate behavioral differences, pregrouping defense tests failed to predict subordinate status. However, pregrouping defense scores were reliably correlated with subordinate pre-postgrouping change scores for voluntary ethanol consumption. Subordinates showed higher ranked ethanol consumption than dominants, but these groups were not different on pregrouping ethanol consumption. Subordinate postgrouping ethanol consumption was positively correlated with pregrouping attack toward an adult intruder, consonant with previous findings that highly aggressive subordinates are the targets of more intense attack by dominants. These results provide further support for a view that subordination stress increases voluntary ethanol consumption in male rats and suggest some additional individual differences factors that may be involved in increased ethanol consumption for male subordinates. © 1992 Wiley-Liss, Inc.     

Fear and aggression in the rat

The effect of fear on two types of aggression in rats was investigated by adding a cat stimulus to a colony in which the dominant male was attacking an intruder (offensive aggression), or, to a tube test situation in which defensive biting was measured before and during tail shock. The cat completely abolished offense in the colony; when the cat was presented and removed before a strange rat was placed in the colony, attack on the intruder was also reduced. In contrast, defensive biting was unchanged or even slightly potentiated by the presence of the cat, demonstrating a separation of the effects of fear on offensive and defensive aggression.     

Escaping the Dark Side of Curiosity

Curiosity as a clinical entity has been a neglected subject in the psychoanalytic literature. Freud never addressed the issue of curiosity systematically. His interest was in trying to account for children's sexual questioning. Nevertheless, hinderance to internal curiosity—this is to say, that which intimidates and abates the appetite for an exploration of one's motives—is part and parcel of psychoanalytic inquiry. And, arguably, there is no greater clinical challenge for the analyst than trying to treat an analysand who appears to lack an interest in the underlying causes of his unhappiness. The problem of impeded self-inquiry is usually exacerbated in people with more serious emotional disturbances. My position here is that in studying the conditions that mitigate against curiosity in a seriously disturbed patient, we gain access to an enlarged version of the curiosity problems of our less disturbed patients. Here I interpret my clinical impressions about problems with curiosity with ideas from the writings of Martin Buber and Albert Camus.     

The Dental Subscale of the Children's Fear Survey Schedule: Predictive Value and Clinical Usefulness

This study reports on the predictive value and clinical usefulness of the Dutch parental version of the Dental Subscale of the Children's Fear Survey Schedule (CFSS-DS). Parents of 718 children (4–12 years) completed this CFSS-DS version before or during the child's visit. The dentist rated the child's dental fear during treatment on a 5-point Likert-type Scale from 1 (not afraid at all) to 5 (very afraid). Reliability analysis was performed, and correlation coefficients between the two measures were calculated. The reliability of the scale proved to be high (Cronbach's = .93) and significant correlation coefficients were found (r = .58 and r = .68, p < .01). The negative predictive value of the CFSS-DS was high (.96), whereas its positive predictive value was relatively low (0.41). It was concluded that the CFSS-DS might be of clinical value as a screening device of dental fear, whereas its predictive value of fearful behavior should not be overestimated.     

Predictors of Self-Reported Anxiety and Panic Symptoms: An Evaluation of Anxiety Sensitivity, Suffocation Fear, Heart-Focused Anxiety, and Breath-Holding Duration

The purpose of this study was to examine the extent to which anxiety-related individual difference variables predict anxious responding when individuals experience aversive bodily sensations. Thus, we explore several psychological and behavioral predictors of response to a single 25-sec inhalation of 20% carbon dioxide-enriched air in 70 nonclinical participants. Predictor variables included anxiety sensitivity, suffocation fear, heart-focused anxiety, and breath-holding duration. Multiple regression analyses indicated that only anxiety sensitivity significantly predicted postchallenge panic symptoms, whereas both anxiety sensitivity and suffocation fear predicted postchallenge anxiety. These data are in accord with current models of panic disorder that emphasize the role of fear of fear in producing heightened anxiety and panic symptoms and help clarify specific predictors of anxiety-related responding to biological challenge.     

The role of posttraumatic fear and social support in the relationship between trauma severity and posttraumatic growth among adolescent survivors of the Yaan earthquake

Middle school students in Lushan county (N = 315) were assessed 6 months after the Yaan earthquake using a trauma severity questionnaire, a posttraumatic fear questionnaire, a social support questionnaire and a posttraumatic growth inventory to examine the effects of posttraumatic fear and social support in the relationship between trauma severity and posttraumatic growth (PTG). The results showed that posttraumatic fear mediated the relationship between trauma severity and PTG, and social support moderated the relationship between posttraumatic fear and PTG. These findings suggested that trauma severity could be positively associated with PTG in a direct way or in an indirect way through posttraumatic fear. Moreover, posttraumatic fear had a positive relation to PTG under the condition of high social support level, whereas the relation was non‐significant when the level of social support was low. These results were discussed in terms of their implications for adolescents after trauma.