Impaired emotion recognition in music in Parkinson’s disease

Music has the potential to evoke strong emotions and plays a significant role in the lives of many people. Music might therefore be an ideal medium to assess emotion recognition. We investigated emotion recognition in music in 20 patients with idiopathic Parkinson’s disease (PD) and 20 matched healthy volunteers. The role of cognitive dysfunction and other disease characteristics in emotion recognition was also evaluated.     

Proverb interpretation changes in aging

Recent investigations have emphasized the involvement of fronto-subcortical networks to proverb comprehension. Although the prefrontal cortex is thought to be affected by normal aging, relatively little work has been carried out to investigate potential effects of aging on proverb comprehension. In the present investigation participants in three age groups were assessed on a proverb comprehension task and a range of executive function tasks. The older group showed impairment in selecting correct interpretations from alternatives. They also showed executive function deficits, as reflected by reduced working memory and deficient set shifting and inhibition abilities. The findings of the present investigation showed proverb comprehension deficits in normal aging which appeared to be related to reduced executive skills.     

Executive Functions in Preschool Children with Aggressive Behavior: Impairments in Inhibitory Control

The question whether executive function (EF) deficits in children are associated with conduct problems remains controversial. Although the origins of aggressive behavior are to be found in early childhood, findings from EF studies in preschool children with aggressive behavior are inconsistent. The current study aimed to investigate whether preschool children with aggressive behavior show impairments in EF. From a population-based sample, 82 preschool children who were showing aggressive behavior as indicated by scores at or above the 93rd percentile on the Aggressive Behavior Scale of the CBCL 1 1/2-5 were selected. These children with aggressive behavior were matched on IQ to a group of typically developing control children (N = 99). Six neuropsychological tasks were administered to assess set shifting, inhibition, working memory and verbal fluency. A factor analysis was conducted which yielded one clear factor: inhibition. Aggressive preschool children showed poorer performance on this inhibition factor than control children and boys performed worse on this factor than girls. This association between aggressive behavior and inhibition deficits was maintained after controlling for attention problems. In addition, gender differences in all EFs measured were found with boys exhibiting more impairment in EF than girls. These findings demonstrate that preschool children with aggressive behavior show impairments in inhibition, irrespective of attention problems.     

The role of strategies in deciding advantageously in ambiguous and risky situations

In decision situations of everyday life, the potential positive or negative consequences of a decision are often specified and the associated probabilities are known or they are principally calculable ("decisions under risk"). On the basis of correlations reported in patient studies, it has been recently proposed that decisions under risk involve strategic components, i.e. calculation of the risk, as well as emotional processes, i.e. processing feedback from previous decisions. However, the potential impact of calculative strategies on decision-making under risk has not been investigated systematically, so far. In the current study, we examined 42 healthy subjects (21 females) with the Game of Dice Task measuring decisions under risk, and a questionnaire assessing strategy application in items comparable to the choices in the Game of Dice Task. In addition, the subjects performed the Iowa Gambling Task, examining decision-making under ambiguity, and a neuropsychological test battery focusing on executive functions. Results indicate that deciding advantageously in a decision-making task with explicit and stable rules is linked to applying calculative strategies. In contrast, individuals who decide intuitively prefer risky or disadvantageous choices in the Game of Dice Task. Applying calculative strategies was correlated with executive functions but not with performance on the Iowa Gambling Task. The results support the view that calculative processes and strategies may improve decision-making under explicit risk conditions.     

Sorting between dimensions: conditions of cognitive flexibility in preschoolers

The Dimensional Change Card Sorting task frequently is used to measure extradimensional shifting abilities in preschool children. In two studies, we investigated what makes this extradimensional shifting task difficult. In Study 1 with 61 2- to 4-year-olds, we showed that extradimensional shifts from one dimension to another are more difficult than reversal shifts within a dimension (even with irrelevant variation on a second dimension). Study 2 with 77 3- and 4-year-olds further confirmed this finding using a computerized paradigm and showed that sorting instructions are critical for 3-year-olds' difficulties with extradimensional shifts. This finding is taken to suggest that 3-year-olds have particular problems with spontaneously classifying one object in two different ways.     

Aging and strategic retrieval in a cued-recall test: the role of executive functions and fluid intelligence

Cued-recall in episodic memory was investigated in relation to low and high cognitive support at retrieval, executive function level and fluid intelligence level in 81 healthy adults divided first into two age groups (young and elderly adults). The first analyses showed that age-related differences were greater when a low cognitive support was provided to recall the words. An individual index of loss of performance when the number of cues was decreased was then calculated. Hierarchical regression analysis revealed that the executive functions measure (perseverative errors on the Wisconsin Card Sorting Test) was a better candidate than the fluid intelligence measure (Cattell's culture fair test) to account for the age-related variance of the size of performance loss. These findings suggest that age differences in implementing strategic retrieval may be mainly due to a decline in executive functions.     

A derived transfer of functions and the implicit association test

Participants were trained in a series of interrelated conditional discriminations that aimed to establish four 4-member equivalence classes (i.e., A1-B1-C1-D1, A2-B2-C2-D2, A3-B3-C3-D3, A4-B4-C4-D4). During this training, the four A stimuli (i.e., A1, A2, A3, and A4) were compounded with pictures containing positive or negative evaluative functions (A1/A2 negative & A3/A4 positive). The transfer of evaluative functions to directly and indirectly related members of the equivalence classes (i.e., B, C, and D stimuli) was measured using an Implicit Association Test (IAT). During consistent test blocks, participants were required to press the same response key for target words that were related to those A stimuli that possessed similar evaluative functions (A1/A2-left key & A3/A4-right key). During inconsistent test blocks, target words that were related to those A stimuli with different evaluative functions were assigned to the same response key (A1/A4-left key & A2/A3-right key). Results showed that all 8 participants, who passed a matching-to-sample equivalence test following the IAT, responded more rapidly on consistent relative to inconsistent test blocks. This typical IAT effect was not observed for those participants who did not pass the equivalence test. The results suggest that the IAT effect may arise from formally untested derived relations, and supports the argument that such relations could provide a valid behavioral model of semantic categories in natural language.     

前临床期痴呆的认知特征：当前研究进展和未来研究展望

在这篇文章中, 我将讨论从正常老化到痴呆, 这一通常被称为痴呆前临床阶段的认知功能的转变。研究表明, 阿尔茨海默症和血管性痴呆病人在临床确诊之前的几年中, 会出现明显的认知损伤。早期最突出的损伤存在于情节记忆、加工速度以及执行功能。这些功能性损伤与神经生物学研究证实的边缘系统和新皮层区存在多重损伤是相一致的。虽然早在临床诊段之前, 病人组和控制组的平均成绩存在巨大差异, 但同时这两组测试成绩的分布在很大程度上是重叠的。寻求降低这种重叠度的方法是未来研究的一个重要任务。这有可能通过将认知的和其他指标(如基于脑的、基因的、临床的、社会的)相结合构建预测模型来实现。此外, 在未来研究中以下三方面也是急需考虑问题: (a) 找出在 前临床期间认知功能急速下降的时间点: (b) 评估从前临床到临床诊断变化速率中存在的个体差异; (c) 确定特定因素与随后发生的痴呆之间的关联强度是如何随时间向临床确诊推进而逐渐变化的。     

Use of samples differing markedly in salience may encourage use of a single-code/default strategy in matching-to-sample in pigeons

To test the hypothesis that pigeons will only code the more salient sample when samples differ markedly in salience, pigeons were trained with samples consisting of a 2-s presentation of food (highly salient sample) and an 8-s presentation of keylight (less salient sample). During retention testing, pigeons tended to respond at longer delays as if an 8-s keylight sample had been presented. This finding is consistent with use of a single-code/default strategy in which only the 2-s food sample was coded and the comparison associated with an 8-s keylight sample was selected by default in the absence of memory for the salient 2-s food sample. Hence, a marked difference in sample salience appears to encourage use of a single-code/default strategy.     

Executive functions after age 5: Changes and correlates

Research and theorizing on executive function (EF) in childhood has been disproportionately focused on preschool age children. This review paper outlines the importance of examining EF throughout childhood, and even across the lifespan. First, examining EF in older children can address the question of whether EF is a unitary construct. The relations among the EF components, particularly as they are recruited for complex tasks, appear to change over the course of development. Second, much of the development of EF, especially working memory, shifting, and planning, occurs after age 5. Third, important applications of EF research concern the role of school-age children’s EF in various aspects of school performance, as well as social functioning and emotional control. Future research needs to examine a more complete developmental span, from early childhood through late adulthood, in order to address developmental issues adequately.